Parlow, John J.’s team published research in Journal of Heterocyclic Chemistry in 1998-12-31 | CAS: 217314-47-1

Journal of Heterocyclic Chemistry published new progress about Herbicides. 217314-47-1 belongs to class esters-buliding-blocks, name is Methyl 3-amino-5-methoxybenzoate, and the molecular formula is C9H11NO3, Category: esters-buliding-blocks.

Parlow, John J. published the artcileSynthesis of pyrazolecarbonylaminopyridinecarboxamides as herbicides, Category: esters-buliding-blocks, the main research area is pyridinecarboxamide pyrazolecarboxamide preparation herbicide; pyrazolecarboxamidopyridinecarboxamide preparation herbicide.

Target compounds from a herbicide lead area, pyrazolecarboxamides, were selected and synthesized. These targets were chosen based on structural similarities with other known bleaching herbicides and the structure activity relationship previously established with analogs of one of the lead compounds Syntheses of the three target compounds I (X, R = C, MeO; N, MeO; N, H) were accomplished, two of which involved various transformations and regioselective additions with a pyridine nucleus to afford novel pyridine derivatives I were tested in whole plant assays with the herbicidal data reported.

Journal of Heterocyclic Chemistry published new progress about Herbicides. 217314-47-1 belongs to class esters-buliding-blocks, name is Methyl 3-amino-5-methoxybenzoate, and the molecular formula is C9H11NO3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parlow, John J.’s team published research in Journal of Heterocyclic Chemistry in 1998-12-31 | CAS: 217314-47-1

Journal of Heterocyclic Chemistry published new progress about Herbicides. 217314-47-1 belongs to class esters-buliding-blocks, name is Methyl 3-amino-5-methoxybenzoate, and the molecular formula is C9H11NO3, Category: esters-buliding-blocks.

Parlow, John J. published the artcileSynthesis of pyrazolecarbonylaminopyridinecarboxamides as herbicides, Category: esters-buliding-blocks, the main research area is pyridinecarboxamide pyrazolecarboxamide preparation herbicide; pyrazolecarboxamidopyridinecarboxamide preparation herbicide.

Target compounds from a herbicide lead area, pyrazolecarboxamides, were selected and synthesized. These targets were chosen based on structural similarities with other known bleaching herbicides and the structure activity relationship previously established with analogs of one of the lead compounds Syntheses of the three target compounds I (X, R = C, MeO; N, MeO; N, H) were accomplished, two of which involved various transformations and regioselective additions with a pyridine nucleus to afford novel pyridine derivatives I were tested in whole plant assays with the herbicidal data reported.

Journal of Heterocyclic Chemistry published new progress about Herbicides. 217314-47-1 belongs to class esters-buliding-blocks, name is Methyl 3-amino-5-methoxybenzoate, and the molecular formula is C9H11NO3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ragan, John A.’s team published research in Synthesis in 1998-11-30 | CAS: 217314-47-1

Synthesis published new progress about Amino group. 217314-47-1 belongs to class esters-buliding-blocks, name is Methyl 3-amino-5-methoxybenzoate, and the molecular formula is C9H11NO3, Quality Control of 217314-47-1.

Ragan, John A. published the artcile2,5-Dimethylpyrrole protection facilitates copper(I)-mediated methoxylations of aryl iodides in the presence of anilines, Quality Control of 217314-47-1, the main research area is iodoaniline copper mediated methoxylation methylpyrrole protection; aniline methoxy preparation; methoxybenzenamine preparation; benzenamine methoxy preparation.

Converting iodoanilines to the corresponding 2,5-dimethylpyrroles facilitates CuCl-mediated methoxide substitution. Examples with ortho-, meta-, or para relationships between the iodide and aniline are presented. Several other aniline blocking groups were investigated and found not to be successful in this sequence.

Synthesis published new progress about Amino group. 217314-47-1 belongs to class esters-buliding-blocks, name is Methyl 3-amino-5-methoxybenzoate, and the molecular formula is C9H11NO3, Quality Control of 217314-47-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

17-Sep-2021 News Share a compound : 217314-47-1

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 217314-47-1, name is Methyl 3-amino-5-methoxybenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: 217314-47-1

To the solution of 1.57 g (8.7 mmol, 1 eq) 3-amino-5-methoxy-benzoic acid methyl ester (CAS 217314-47-1, can be prepared according to literature procedures) and 0.11 g (0.87 mmol, 0.1 eq) 4-dimethylaminopyridine in 18 ml THF is added the solution of 1.89 g (8.7 mmol, 1 eq) BOC-anhydride in 7 ml THF. The reaction mixture is stirred at rt over night. After dilution with EtOAc the mixture is washed with aqueous sodium bicarbonate and brine, dried over sodium sulfate, and the solvents are evaporated at reduced pressure. The residue is purified by chromatography on silica (flashmaster, hexane to hexane/EtOAc 7/3) to give 0.83 g (2.9 mmol, 34%) product as white solid.MS (LC/MS): 182=[M+H]+ 1H-NMR (400 MHz, CDCl3): 7.54-7.51 (m, 1H), 7.39 (br s, 1H), 7.29-7.28 (m, 1H), 6.59 (br s, 1H), 3.93 (s, 3H), 3.87 (s, 3H), 1.56 (s, 9H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Betschart, Claudia; Lerchner, Andreas; Machauer, Rainer; Rueger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob; US2008/132477; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

7-Sep-21 News The important role of 217314-47-1

The synthetic route of Methyl 3-amino-5-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference of 217314-47-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 217314-47-1, name is Methyl 3-amino-5-methoxybenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(i) Methyl 3-((4-((4-((tert-butoxycarbonvnamino)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxybenzoateA flask charged with tert-butyl (4-((2-chloropyridin-4-yl)oxy)naphthalen-1-yl)carbamate (see Example 2(ii) above; 20.1 g, 54.2 mmol), methyl 3-amino-5-methoxybenzoate (10.80 g, 59.6 mmol), BrettPhos G1 Precatalyst (550 mg, 0.689 mmol) and K2C03(14.98 g, 108 mmol) in anhydrous tBuOH (300 ml.) was back filled with nitrogen (x3) and then placed on a heating block (preheated to 90C). The suspension was degassed with nitrogen, stirred for 8 h and then cooled to rt and stirred for 8 h. Reaction mixture was warmed to 50C then cooled to rt and diluted with DCM (1 L), the suspension was filtered through Celite and the solvent evaporated. The brown oil was sonicated with diethyl ether (500 ml.) and the solid filtered under suction, washing with further diethylether, to afford the sub-title compound (21.55 g) as a beige solid. 1H NMR (400 MHz, DMSO-d6) delta 9.37 (s, 1 H), 9.19 (s, 1 H), 8.15 (s, 1 H), 8.13 (s, 1 H), 7.85 (dd, 1 H), 7.76 (dd, 1 H), 7.69 (dd, 1 H), 7.66-7.54 (m, 3H), 7.37 (d, 1 H), 6.96 (dd, 1 H), 6.62 (dd, 1 H), 6.09 (d, 1 H), 3.82 (s, 3H), 3.75 (s, 3H), 1.53 (s, 9H). (90% purity). LCMS m/z 516 (M+H)+(ES+); 514 (M-H)”(ES”)

The synthetic route of Methyl 3-amino-5-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some tips on 217314-47-1

Related Products of 217314-47-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 217314-47-1 name is Methyl 3-amino-5-methoxybenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Related Products of 217314-47-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 217314-47-1 name is Methyl 3-amino-5-methoxybenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate H5: Methyl 3-((4-((4-aminonaphthalen-1 -yl)oxy)pyrimidin-2-yl)a methoxybenzoate. Intermediate G2(P) n erme a e OMe To a mixture of Intermediate G2(P) (41.0 g, 1 10 mmol) and methyl 3-amino-5-methoxy benzoate (20.3 g, 111 mmol) in THF (200 mL) was added p-TSA (592 mg, 3.11 mmol) and the resulting suspension was heated at 60C for 18 hr. The reaction mixture was cooled to RT and the suspended solids were collected by filtration, washed with THF (2 x 100 mL) and then re-suspended in a solution of NH3 in MeOH (0.7 M) and stirred vigorously. After 30 min the solid was collected by filtration, washed with NH3 in MeOH (0.7 M) and then dried in vacuo to afford methyl 3-((4-((4-((te/f-butoxycarbonyl)amino)naphthalen-1-yl)oxy)pyrimidin-2- yl)amino)-5-methoxybenzoate, Intermediate H5(P), as a beige solid (34.0 g, 92% purity by HPLC, 56%). To a suspension of Intermediate H5(P) (10.2 g, 92% pure, 18.2 mmol) in DCM (50 mL) was added TFA (10 mL, 130 mmol) dropwise and the resulting black solution kept at RT for 21 hr. An additional aliquot of TFA (5.0 mL, 67 mmol) was added and after a further 3 hr the reaction mixture was evaporated in vacuo. The residue was co-evaporated with toluene (100 mL) then with a solution of NH3 in MeOH (0.7 M, 2 x 100 mL), triturated with MeOH (100 mL) then the resulting solid was collected by filtration, washed with MeOH (50 mL) and dried in vacuo to afford the title compound, Intermediate H5, as a beige solid (7.9 g, 99%); R* 2.15 min (Method 2 acidic, 92% pure); m/z 417 (M+H)+, (ES+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-amino-5-methoxybenzoate, and friends who are interested can also refer to it.

Reference:
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; CARIOU, Claire, Anne, Marie; CHARRON, Catherine, Elisabeth; FORDYCE, Euan, Alexander, Fraser; HAMZA, Daniel; FYFE, Matthew, Colin, Thor; ITO, Kazuhiro; KING-UNDERWOOD, John; MURRAY, Peter, John; ONIONS, Stuart, Thomas; THOM, Stephen, Malcolm; WATSON, Hayley, Tegan, Angela; WILLIAMS, Jonathan, Gareth; WO2014/27209; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Share a compound : 217314-47-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 217314-47-1, name is Methyl 3-amino-5-methoxybenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: 217314-47-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 217314-47-1, name is Methyl 3-amino-5-methoxybenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: 217314-47-1

To the solution of 1.57 g (8.7 mmol, 1 eq) 3-amino-5-methoxy-benzoic acid methyl ester (CAS 217314-47-1, can be prepared according to literature procedures) and 0.11 g (0.87 mmol, 0.1 eq) 4-dimethylaminopyridine in 18 ml THF is added the solution of 1.89 g (8.7 mmol, 1 eq) BOC-anhydride in 7 ml THF. The reaction mixture is stirred at rt over night. After dilution with EtOAc the mixture is washed with aqueous sodium bicarbonate and brine, dried over sodium sulfate, and the solvents are evaporated at reduced pressure. The residue is purified by chromatography on silica (flashmaster, hexane to hexane/EtOAc 7/3) to give 0.83 g (2.9 mmol, 34%) product as white solid.MS (LC/MS): 182=[M+H]+ 1H-NMR (400 MHz, CDCl3): 7.54-7.51 (m, 1H), 7.39 (br s, 1H), 7.29-7.28 (m, 1H), 6.59 (br s, 1H), 3.93 (s, 3H), 3.87 (s, 3H), 1.56 (s, 9H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Betschart, Claudia; Lerchner, Andreas; Machauer, Rainer; Rueger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob; US2008/132477; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The important role of 217314-47-1

Synthetic Route of 217314-47-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 217314-47-1, name is Methyl 3-amino-5-methoxybenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthetic Route of 217314-47-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 217314-47-1, name is Methyl 3-amino-5-methoxybenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(i) Methyl 3-((4-((4-((tert-butoxycarbonvnamino)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxybenzoateA flask charged with tert-butyl (4-((2-chloropyridin-4-yl)oxy)naphthalen-1-yl)carbamate (see Example 2(ii) above; 20.1 g, 54.2 mmol), methyl 3-amino-5-methoxybenzoate (10.80 g, 59.6 mmol), BrettPhos G1 Precatalyst (550 mg, 0.689 mmol) and K2C03(14.98 g, 108 mmol) in anhydrous tBuOH (300 ml.) was back filled with nitrogen (x3) and then placed on a heating block (preheated to 90C). The suspension was degassed with nitrogen, stirred for 8 h and then cooled to rt and stirred for 8 h. Reaction mixture was warmed to 50C then cooled to rt and diluted with DCM (1 L), the suspension was filtered through Celite and the solvent evaporated. The brown oil was sonicated with diethyl ether (500 ml.) and the solid filtered under suction, washing with further diethylether, to afford the sub-title compound (21.55 g) as a beige solid. 1H NMR (400 MHz, DMSO-d6) delta 9.37 (s, 1 H), 9.19 (s, 1 H), 8.15 (s, 1 H), 8.13 (s, 1 H), 7.85 (dd, 1 H), 7.76 (dd, 1 H), 7.69 (dd, 1 H), 7.66-7.54 (m, 3H), 7.37 (d, 1 H), 6.96 (dd, 1 H), 6.62 (dd, 1 H), 6.09 (d, 1 H), 3.82 (s, 3H), 3.75 (s, 3H), 1.53 (s, 9H). (90% purity). LCMS m/z 516 (M+H)+(ES+); 514 (M-H)”(ES”)

The synthetic route of Methyl 3-amino-5-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simple exploration of 217314-47-1

The synthetic route of 217314-47-1 has been constantly updated, and we look forward to future research findings.

Application of 217314-47-1, These common heterocyclic compound, 217314-47-1, name is Methyl 3-amino-5-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Aniline 14.4 is treated which sulfonyl chloride 2 to give the corresponding sulfonamide 15.2, which is followed by the treatment of NaH to afford the cyclic sulfonamide 15.3. Basic hydrolysis (LiOH, H20/THF/MeOH) of compound 15.3 gives acid 15.1 as the intermediateds for example 57.

The synthetic route of 217314-47-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNESIS PHARMACEUTICALS, INC.; WO2003/106405; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics