Related Products of 2171-74-6, A common heterocyclic compound, 2171-74-6, name is Benzo[d][1,3]dioxol-2-one, molecular formula is C7H4O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Molar ratio between the reagents PCC:ethanol = 1:6.In a two-neck flask 520 jil of ethanol, the basic catalyst (sodium methoxide, in a molar ratio of 1 to 30 with respect to the PCC, 0.003 g),and in the end the PCC (0.201g) are initially added.Subsequently, the flask is equipped with two condensers, rinsed and placed in inert nitrogen atmosphere (refrigerants closed at the ends by suitable caps) and heated, in an oil bath and under magnetic stirring, at the temperature of 60C for one hour.After the reaction, the mixture is rapidly cooled to room temperature and the whole is recovered and solubilized in 10 ml of HPLC acetone. 10 il of decane as an internal standard for the analysis are then added.Gas chromatographic analysis was performed with a Focus-GC instrument model of Thermo, equipped with a HP-5 capillary column anda FID detector.The desired product (DEC) is obtained with a gas chromatographic yield of 93% with a total conversion of the limiting reagent (PCC), without any substantial trace of undesired products, beside the catechol (co-product of the reaction).
The synthetic route of 2171-74-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALMA MATER STUDIORUM – UNIVERSITA DI BOLOGNA; UNIVERSITA CA’ FOSCARI; TABANELLI, Tommaso; CAVANI, Fabrizio; SELVA, Maurizio; (37 pag.)WO2017/51363; (2017); A1;,
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