214262-88-1, Adding a certain compound to certain chemical reactions, such as: 214262-88-1, name is Methyl 2-(2-chloro-4-fluorophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 214262-88-1.
Example 25. 2-(2-chloro-4-fluorophenyl)- 6-methoxy -8-(6-methyl-7-oxo-6,7-dihydro- -pyrrolo[2,3-c]pyridin-4-yl)-2H-l,4-benzoxazin-3(4H)-one A solution of methyl (2-chloro-4-fluorophenyl)acetate (100 mg, 0.5 mmol) (Acros Organics cat 30478) and N-bromosuccinimide (90 mg, 0.5 mmol) in carbon tetrachloride (0.7 mL) was heated to 100 C for 1 h. The reaction mixture was cooled to room temperature, filtered, and partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over MgSC , filtered, and concentrated to afford crude methyl bromo(2-chloro-4-fluorophenyl)acetate as light yellow semi solid (120 mg, 90%).
According to the analysis of related databases, 214262-88-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INCYTE CORPORATION; COMBS, Andrew, P.; MADUSKUIE, Thomas, P., Jr.; FALAHATPISHEH, Nikoo; WO2015/164480; (2015); A1;,
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