Category: 213598-10-8

Adding a certain compound to certain chemical reactions, such as: 213598-10-8, name is Methyl 3-bromo-4-isopropoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 213598-10-8, Recommanded Product: 213598-10-8

Step C: Methyl 3-cyano-4-isopropyloxybenzoate; A mixture of 1.32 g (4.83 mmol) of methyl 3-bromo-4-isopropyloxybenzoate (from Step B), 341 mg (2.90 mmol) of zinc cyanide, 67 mg (0.12 mmol) of 1, 1′- bis (diphenylphosphino) ferrocene, 44 mg (0.05 mmol) of tris (dibenzylideneacetone) dipalladium (0)-chloroform complex and 50 L ofH20 in 5.0 mL of DMF was stirred at 120 C for 48 h. The mixture was cooled, then partitioned between EtOAc and sat’d NaCl. The aqueous layer was separated and extracted with 3 x EtOAc. The organic layers were combined, dried over MgS04 and concentrated. Chomatography on a Biotage 40M cartridge using 9: 1 v/v hexanes/EtOAc gave 802 mg of the title compound : 1H NMR (500 MHz, CDC13) 8 1.44 (d, J = 6.2, 6H), 3.91 (s, 3H), 4. 71-4. 79 (m, 1H), 6.99 (d, J = 8.9, 1H), 8.18 (dd, J = 2.2, 8.8, 1H), 8.24 (d, J=2. 1, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-bromo-4-isopropoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; WO2005/58848; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 213598-10-8, name is Methyl 3-bromo-4-isopropoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 213598-10-8

Description 4: Methyl 3-cyano-4[(1-methylethyl)oxy]benzoate To a solution of methyl 3-bromo-4-[(1-methylethyl)oxy]benzoate (25 g, 91.575 mmol) (Description 3) in DMF (250 mL), under a nitrogen atmosphere, was added zinc cyanide (43 g, 366.3 mmol) and tetrakis(triphenylphosphine)palladium(0) (21 g, 18.32 mmol) and the reaction mixture heated to 120 C. and stirred overnight. After cooling, the mixture was filtered and the filtrate combined with an identical reaction performed on the same scale and DCM (1.5 L) and water (1.5 L) added. The organic phase was separated and the aqueous phase was extracted with DCM (3×300 mL). The combined organic layers were washed with water, dried over sodium sulfate and concentrated. The residue was purified by column chromatography on silica (petroleum ether :ethyl acetate (20:1) to afford the title compound (36 g). 1H NMR (CDCl3, 400 MHz) 5 ppm: 1.45 (6H, d, J=6.0 Hz), 3.92 (3H, s), 4.76 (1H, m), 7.00 (1H, d, J 9.0), 8.19 (1H, dd, J 9.0, 2.0 Hz), 8.26 (1H, d, J=2.0 Hz).

The synthetic route of Methyl 3-bromo-4-isopropoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO WELLCOME HOUSE; US2012/283297; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 213598-10-8, name is Methyl 3-bromo-4-isopropoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 213598-10-8, Recommanded Product: Methyl 3-bromo-4-isopropoxybenzoate

Compound 22-1 (200 mg, 0.732 mmol) was dissolved in MeOH (5.00 mL). Lithium hydroxide monohydrate (61.5 mg, 1.46 mmol) and water (1.00 mL) were added. The mixture was stirred at 10 C. for 16 hours. The reaction solution was concentrated. The residue was added in water (3 mL) and extracted with dichloromethane (5 mL×1). The organic phase was discarded. The aqueous phase was adjusted to pH 5-6 with hydrochloric acid (1 mol/L), and extracted with dichloromethane (5 mL×2). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated to afford compound 22-2.1H NMR: (400 MHz, CDCl3) delta 8.31 (d, J=2.0 Hz, 1H), 8.02 (dd, J=2.0, 8.8 Hz, 1H), 6.94 (d, J=8.8 Hz, 1H), 4.81-4.61 (m, 1H), 1.44 (d, J=6.0 Hz, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-bromo-4-isopropoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MEDSHINE DISCOVERY INC.; ZHANG, Peng; WU, Lingyun; YIN, Jun; LI, Jian; CHEN, Shuhui; (121 pag.)US2020/48235; (2020); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics