Category: 210530-71-5

Electric Literature of 210530-71-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 210530-71-5, name is Methyl 2-(3,4-difluorophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.

2-(3,4-Difluorophenyl)acetylhydrazide (B4)(analogously to WO2004/101512A2, Bioorg. Med. Chem. Lett. 2004, 14(3), 817-822)1.0 g of methyl 2-(3,4-difluorophenyl)acetate (C4) is dissolved in 6.0 ml of 2-propanol. 365 mul of hydrazinium hydroxide are subsequently added, and the reaction solution is heated under reflux for 18 h overnight. The mixture is then evaporated to dryness in vacuo and purified by flash column chromatography on silica gel (solvent gradient: ethyl acetate/0-10% by vol. of ethanol), giving 803 mg of the title compound as a colourless solid having a melting point of 112 C.; MS: 187.1 (MH+); TLC: Rf=0.50 (ethyl acetate/ethanol 9:1 parts by volume).

The chemical industry reduces the impact on the environment during synthesis Methyl 2-(3,4-difluorophenyl)acetate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; US2011/224302; (2011); A1;,
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Electric Literature of 210530-71-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 210530-71-5 as follows.

To a stirred mixture of methyl 2- (3, 4-difluorophenyl) acetate (4.5 g, crude) in CCl4 (50 mL) was added NBS (6.0 g, 33.7 mmol) and HBr/HOAc (1.0 mL) . After the addition, the reaction mixture was stirred for 3 hours at 85. The solid of the reaction was filter out, the filtrate was concentrated, and this residue was dissolved by H2O (50 mL) , extracted with EtOAc (50 mL x 3) , The combined organic layers were washed with brine, dried over Na2SO4, concentrated to give methyl 2-bromo-2- (3, 4-difluorophenyl) acetate (4.0 g, crud) as a yellow oil. MS: M/e 266 (M+1)+

According to the analysis of related databases, 210530-71-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 210530-71-5 as follows. Recommanded Product: Methyl 2-(3,4-difluorophenyl)acetate

Sodium hydride (containing mineral oil at 40%, 0.48 g) was added to a solution of methyl (3,4-difluorophenyl)acetate (CAS No.210530-71-5, 2.04 g) in DMF (30 mL) at 0 C., and the reaction solution was stirred at room temperature for 10 minutes. 1-chloro-3-iodopropane (1.3 mL) was added to the reaction solution at 0 C., and the reaction solution was stirred at room temperature for two hours. A saturated ammonium chloride solution was added to the reaction solution, followed by extraction with ethyl acetate. The resulting extract washed with a saturated sodium chloride solution. The resulting organic layer was dried over magnesium sulfate and then concentrated under reduced pressure. Hydrazine monohydrate (5.5 g) was added to a solution of the resulting residue in ethanol (50 mL) at room temperature, and the reaction solution was stirred at 80 C. for seven hours. The reaction solution was left to cool to room temperature and concentrated under reduced pressure. A saturated sodium bicarbonate solution was added to the residue, followed by extraction with chloroform. The resulting extract was dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent:heptane-ethyl acetate system, then ethyl acetate-methanol system) to obtain 1.42 g of the title compound. The property values of the compound are as follows. ESI-MS; m/z 227 [M++H]. 1H-NMR (CDCl3) delta (ppm): 1.84-2.06 (m, 3H), 2.10-2.21 (m, 1H), 3.53-3.71 (m, 3H), 4.59 (brs, 2H), 6.89-6.95 (m, 1H), 6.97-7.05 (m, 1H), 7.06-7.26 (m, 1H).

According to the analysis of related databases, 210530-71-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/219181; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics