Category: 20781-20-8

20781-20-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20781-20-8 as follows.

To a solution of(2R,6R,I 1R)-tert-butyl 6,1 i-dimethyh8(trifiuoromethyl)sulfonyl)oxy)-i ,2,5,6-tetrahydro-2,6-methanobenzo[diazocine3(4H)carboxyiate (5.32 g, 11.8 mmoi) in degassed dimethyl sulfone (50 mL), wasadded Nhydroxysuccinimide (233 g, 23.7 rnmoi), palladium acetate (265 nig, 118 mmol), triethylamine (3.3 mL, 23,7 mmoi) and 4,5-bis(diphenylphosphino)95- dimethyixanthene (683 mg, 1.1 8 mrnoi). The reaction mixture was heated with carbon monoxide (latm) at 70C overnight. The reaction mixture was cooled toambient temperature and 2,4-dimethoxybenzylamine (2.17 mg. 13.0 rnmol) added. The mixture was stirred for 2 hours diluted with ethyl acetate (800 rnL), and filtered tiu?ough cehte. The organic solution was washed twice with water (800 inL), hrine (300 mL), and dried (MgSO4). Filtration and removal of the solvent under reduced pressure gave crude material that was purified by silica chromatography(EtOAc(i):heptanes(l)) to give (2R,6R.l 1R)-tert-butyi 8-((2,4- dimethoxyhenzyl)carhamoyi)6, Ii dimethyl- I ,2,5,6..tetrahydro-2,6- methanohenzo[dazocine-3(4i-I)-carhoxyla1e (4.0 g, 68% yield); L.C/MS(M+H) = 495,3,

According to the analysis of related databases, (2,4-Dimethoxyphenyl)methanamine, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALKERMES PHARMA IRELAND LIMTED; DEAVER, Dan; BLUMBERG, Laura, Cook; EYERMAN, David; WYNN, Thomas; WO2014/190271; (2014); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20781-20-8, 20781-20-8

Example 162: 3-Fluoro-8-isopropyl-10-methyl-11-oxo-/V-piperidin-4-yl-10,11- dihydrodibenzo[6,f][1 ,4]thiazepine-7-sulfonamide 5,5-dioxide hydrochlorideStep 1. te/f-Butyl 4-(2,4-dimethoxybenzylamino)piperidine-1-carboxylate[0492] A mixture of terf-butyl 4-oxopiperidine-1-carboxylate (21.0 g, 0.105 mol), 2,4-dimethoxybenzylamine (17.6 g, 0.105 mol), and sodium triacetoxyborohydride (55.8 g, 0.263 mol) were stirred in ethanol (500 ml_) 2 hours at room temperature. Aqueous sodium bicarbonate was added, and the mixture was extracted with dichloromethane. The organic phase was washed with brine, dried over magnesium sulfate and concentrated to a volume of 325 ml_ to afford an approximately 0.323 M solution in dichloromethane of terf-butyl 4-(2,4-dimethoxybenzylamino)piperidine-1- -carboxylate which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2,4-Dimethoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WYETH; WO2008/61029; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem