Category: 207346-42-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 207346-42-7, name is Methyl 2-amino-4,5-difluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H7F2NO2

Methyl 2-amino-4,5-difluorobenzoate (14) (250 mg, 1.33 mmol) was dissolved in 4mL DMF. TEA (2.5 eq) and R-tert-butyl(pyrrolidin-3-yl methyl) carbamate (298.5 mg, 1.47 mmol) were added and stirred at 80 C for 5 h. The reaction mixture was dissolved in 20 mLDCM and washed with 10 mL water three times. The organic layer was concentrated by rotary evaporation. The residual DMF was removed by placing under high vacuum overnight. The residue was purified by silica gel chromatography using gradient from 3:1Hexanes:EtOAc to 1:1 Hexanes:EtOAc to yield pure UICK-II-189(15) Yield 73%. 1H NMR (300 MHz, CDCl3) d 7.43 (d, J 15.4 Hz,1H), 5.73 (d, J 7.8 Hz, 1H), 4.70 (bs, 1H, exchangeable), 3.82 (s, 3H),3.53 (m, 3H), 3.20 (m, 3H), 2.47 (m, 1H), 2.08 (m, 1H), 1.71 (m, 1H),1.47 (s, 9H). 19F NMR (282 MHz, CDCl3) d 141.00 (s, 1F). MS (ESI) calculated for (M H) 368.19, found 368.0.

According to the analysis of related databases, 207346-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Delgado, Justine L.; Lentz, Sarah R.C.; Kulkarni, Chaitanya A.; Chheda, Pratik R.; Held, Hailey A.; Hiasa, Hiroshi; Kerns, Robert J.; European Journal of Medicinal Chemistry; vol. 172; (2019); p. 109 – 130;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 207346-42-7, name is Methyl 2-amino-4,5-difluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H7F2NO2

methyl 2-amino-4,5-difluorobenzoate (40.0 g, 214 mmol) and NCS (25.9 g, 194 mmol) were suspended in DMF (10 mL) and heated at 95 C. for 30 min. Water and DCM were added to the mixture. The organic phase was separated. The aqueous phase was extracted with DCM (2 x 10 mL). The combined organic phases were dried, filtered and concentrated. The resulting residue was purified by normal phase chromatography (0 to 40% EtOAc in hexanes) to give compound 148a (11 g, 26% yield) as a white solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 207346-42-7.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXO GROUP LIMITED; YAMAWAKI, KENJI; YOKOO, KATSUKI; SATO, JUN; KUSANO, HIROKI; AOKI, TOSHIAKI; LIAO, XIANG MIN; PEARSON, NEIL DAVID; PENDRAK, ISRAIL; THALGI, REEMA; (373 pag.)JP6377570; (2018); B2;,
Ester – Wikipedia,
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Application of 207346-42-7,Some common heterocyclic compound, 207346-42-7, name is Methyl 2-amino-4,5-difluorobenzoate, molecular formula is C8H7F2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Into a 500mL round bottom flask equipped with a magnetic stir bar was placed methyl 2-amino-6-methoxybenzoate (25 g, 149.6 mmol), ethanol (200 mL), cyanamide (9.43 g, 224 mmol), and concentrated HCl (6 mL). The mixture was allowed to stir at reflux for 6 hours. At one hour intervals, concentrated HCl (0.5 mL) was added. The reaction mixture was allowed to cool to room temperature and the solid, 7i, was isolated via filtration and washed with ethanol. 1H NMR (400 MHz, DMSO-d6) delta ppm 3.88 (s, 3 H), 6.96 (dd, J=8.2, 3.1 Hz, 2 H), 7.69 (t, J=8.3 Hz, 1 H), 8.28 (br. s., 2 H), 12.67 (br. s., 1 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-amino-4,5-difluorobenzoate, its application will become more common.

Reference:
Article; Pieters, Serge; McGowan, David; Herschke, Florence; Pauwels, Frederik; Stoops, Bart; Last, Stefaan; Embrechts, Werner; Scholliers, Annick; Mostmans, Wendy; Van Dijck, Kris; Van Schoubroeck, Bertrand; Thone, Tine; De Pooter, Dorien; Fanning, Gregory; Rosauro, Mari Luz; Khamlichi, Mourad Daoubi; Houpis, Ioannis; Arnoult, Eric; Jonckers, Tim H.M.; Raboisson, Pierre; Bioorganic and Medicinal Chemistry Letters; vol. 28; 4; (2018); p. 711 – 719;,
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Electric Literature of 207346-42-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 207346-42-7, name is Methyl 2-amino-4,5-difluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 70-1 (1.00 g, 5.34 mmol, 1 eq) and 70-lc (1.50 g, 8.02 mmol, 1.5 eq) in DCM (15 mL) were added Cu(OAc)2 (1.40 g, 8.02 mmol, 1.5 eq) and DIEA (1.30 g, 10.69 mmol, 1.8 mL, 2 eq). The mixture was degassed, purged with 02 for 3 times and stirred at 20C for 16 hr. The mixture was concentrated. The residue was dissolved in EA (10 mL) and washed with H20 (3 mL *3). The combined organic layers were washed with brine (3 mL *3), dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified by flash silica gel chromatography to give 70-2 (650.0 mg, 1.96 mmol, 36.7% yield). 1H NMR (400 MHz, CDCl3) d 9.61 (br s, 1H), 7.79 (dd, 7 = 9.0, 11.1 Hz, 1H), 7.58 (d, J= 8.5 Hz, 2H), 7.25 (d, .7= 2.3 Hz, 1H), 7.10 (dd, 7= 6.9, 12.8 Hz, 1H), 3.92 – 3.88 (m, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-4,5-difluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (559 pag.)WO2019/222431; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 207346-42-7, These common heterocyclic compound, 207346-42-7, name is Methyl 2-amino-4,5-difluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2; Synthesis of f4-(6-fluoro-7-methylamino-2,4-dioxo-l,4-dihydro-2H- quinazolin-3-yI)-phenyll-5-chloro-thiophen-2-yl-sulfonyIurea (7a)Step i.Ia 2a 2b[0276] Aniline 1 (1H NMR (DMSO): delta 7.58 (dd, IH), 6.72 (dd, IH), 3.77 (s, 3H); 6.0 g, 32.085 mmol) was placed in a 500 mL round bottomed flask and 20% phosgene in toluene (175 mL, 332.50 mmol, 10.36 equiv) was added. The resulting somewhat sticky suspension was then magnetically stirred overnight at room temperature resulting in a clear, colorless solution. An aliquot removed, blown dry with argon, quenched with MeOH, and analyzed by RP-HPLC/MS to show no unreacted aniline 1 and clean formation of the isocyanate 2a and/or carbamoyl chloride 2b as analyzed as its methyl-carbamate. The mixture was concentrated first by rotary evaporation and then under high vacuum to yield 6.76g (99% yield) of the isocyanate 2a and/or carbamoyl chloride 2b as a free-flowing white solid.

Statistics shows that Methyl 2-amino-4,5-difluorobenzoate is playing an increasingly important role. we look forward to future research findings about 207346-42-7.

Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2008/137809; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

207346-42-7, A common heterocyclic compound, 207346-42-7, name is Methyl 2-amino-4,5-difluorobenzoate, molecular formula is C8H7F2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 30; 2-(5-chlorothiophen-2-yl)-2-(‘4-(6-fluoro-7-(methylaminoV2,4-dioxo-l,2-dihvdroquinazolin- 3(4H)-ylN)-3-methoxybenzamido)acetic acid (51); Scheme 7; [0151] To difluoroanthranalide Ic (5.69 g, 30 mmol), was added phosgene in toluene ((1.9 M, 160 mL, 300 mmol). The reaction mixture was stirred at rt overnight, concentrated in vacuo, evaporated from toluene (20 mL), and dried under vacuum to afford a light beige solid 8a. The material was found to give the desired urea when treated with ammonia but was not otherwise characterized.

The synthetic route of 207346-42-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2008/36843; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics