Category: 2065-23-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2065-23-8, name is Methyl 2-phenoxyacetate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 2065-23-8

To the methyl phenoxyacetate obtained by distillation, 0.09 g of lead acetate having a purity of 99% and1.29g of 99% pure 2,3,4-trichlorothiophene, added 118.34g at 20 C99% pure thionyl chloride is reacted, and the reaction is kept at this temperature for 0.5 h, and distilled at a pressure of 1 kPa to collect a fraction of 110 to 120 C.The methyl 4-chlorophenoxyacetate was obtained in an amount of 200.87 g, and the content was 98.84%.

According to the analysis of related databases, 2065-23-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Hou Yongsheng; Chi Zhilong; Zhang Liguo; Hu Yishan; (15 pag.)CN108947822; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 2065-23-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2065-23-8 name is Methyl 2-phenoxyacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Methyl phenoxyacetate (99.9 g, 0.6 mol) was added dropwise to [CHLOROSULFONIC] acid (279.6 g, 159.5 mL, 2.4 mol) at-5 C at such a rate to maintain internal temperature between 0 to-5 C (addition took about 60 min). Some solid formed during this addition. The cooling bath was removed and the reaction mixture was stirred at room temperature for an additional 1.5 hr. The reaction mixture was poured into a vigorously stirring mixture of dichloromethane (900 mL) and methanol (100 [ML)] at [0 C.] After 15 min the cooling bath was removed and the resulting mixture was stirred at room temperature for 1 hr. The resulting mixture was washed with ice cold water (2 X 250 mL). The combined aqueous layers were back extracted with dichloromethane [(1] X 250 mL). The combined organic layers were washed with brine [(1 X] 200 mL), dried over anhydrous magnesium sulfate (15 g) and concentrated under reduced pressure to give 132 g (83%) of the title compound as a white solid.’H NMR [(60MHZ)] [(CDC13)] 8 8.2-7. 2 (AB, 4H), 4.95 (s, 2H), 3.95 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-phenoxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; GARST, Michael, E.; SACHS, George; SHIN, Jai, Moo; WO2004/9583; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2065-23-8, name is Methyl 2-phenoxyacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2065-23-8, HPLC of Formula: C9H10O3

General procedure: An aqueous CH3CN solution (CH3CN54 ml, H2O 6 ml) of N-Boc Val-OMe1a (0.6 mmol, 10 mM), phenanthrene(0.6 mmol, 10 mM), 1,4-dicyanobenzene (0.6 mmol, 10 mM) and NaOH (3 mmol, 50 mM)in three Pyrex vessels (18 mm x 180 mm) was purged with argon for 10 min andadded by acrylonitrile 2a (0.6 mmol,10 mM) under argon atmosphere. The mixture was heated by water bath at 40 for 2h and irradiated with a 100-W high-pressure mercury lamp for 3 h at roomtemperature. Then the mixture was evaporated, and the resulting residue wasdissolved in EtOAc and washed with water, dried over Na2SO4,and concentrated under reduced pressure. The product was purified by silica gelcolumn chromatography using hexane and EtOAc as eluents to give adduct 3a

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Saito, Hikaru; Kanetake, Takayuki; Osaka, Kazuyuki; Maeda, Kousuke; Morita, Toshio; Yoshimi, Yasuharu; Tetrahedron Letters; vol. 56; 13; (2015); p. 1645 – 1648;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

2065-23-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2065-23-8, name is Methyl 2-phenoxyacetate, A new synthetic method of this compound is introduced below.

REFERENCE EXAMPLE 90 Dimethyl 2-oxo-3-phenoxy-propylphosphonate 90 STR109 Dimethyl methylphosphonate (18 ml, 0.166 mol) was addded to anhydrous THF (150 ml) under argon atmosphere and cooled to -78 C. After 20 min. a solution of n-butyl lithium in hexane (1.59N, 108.8 ml, 0.173 mmol) was added to the mixture. After being stirred for 30 min. a solution of methyl phenoxyacetate (10 ml, 0.069 mmol) in 10 ml of anhydrous THF was added, and the reaction mixture was stirred successively for 30 min. at -78 C. and for 30 min. at room temperature, and acidified with acetic acid. After confirming a weakly acidic pH of the solution thus obtained, THF was distilled out. Water (50 ml) was added to the residue, and the resulting mixture was extracted with ethyl acetate (150 ml*3). The combined organic layers were washed with 100 ml of water and with 100 ml of brine, dried over anhydrous sodium sulfate, and concentrated. The oily product was distilled under reduced pressure to afford dimethyl 2-oxo-3-phenoxypropylphosphonate (14.65 g, 0.057 mol, yield: 82.3%). B.p.: 145-147 C./0.1 mmHg. The product was identified by the following data. IR(liquid film): 3450, 3070, 3025, 2960, 2920, 2860, 1740, 1605, 1595, 1495, 1460, 1430, 1405, 1370, e1300, 1250, 1230, 1180, 1160, 1100, 1030, 890, 830, 810, 800 cm-1. NMR(90 MHz, CDCl3, delta): 3.27(2H, d, J=22.7 Hz); 3.77(6H, d, J=11.2 Hz); 4.69(2H, s); 6.84-7.38 (5H, m).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Toray Industries, Inc.; US4775692; (1988); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics