Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19878-18-3, name is trans-Ethyl 4-(aminomethyl)cyclohexanecarboxylate hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C10H20ClNO2
To a mixture of trans-4-(aminomethyl)cyclohexaneethylcarboxylate hydrochloride (3.00 g, 13.5 mmol) prepared as above and K2CO3 (3.73 g, 27.1 mmol) in CH3CN (100 mL) at 09C was added a solution of bromoacetyl bromide (1.1 mol equiv in 20 mL of CH3CN) slowly over 1 h. After 18 h of stirring at 80 C., the inorganic salts were removed by filtration and the organic phase was evaporated under reduced pressure. The residue was washed with H2O (30 mL¡Á3 times) and dissolved in CH2Cl2. The organic phase was dried over Na2SO4, filtered, and evaporated to give a crude product which was further purified by chromatography on silica [gradient elution CH2Cl2 to 30% ethyl acetate (EA)-CH2Cl2, Rf=0.5 (EA/CH2Cl2=4:6)] to obtain ethyl 4-((2-bromoacetamido)methyl)cyclohexanecarboxylate as a white solid. Yield: 2.49 g (60%). 1H NMR (CDCl3): delta=6.54 (br, 1H, -CONH-), 4.12 (q, 2H, -OCH2CH3), 3.90 (s, 2H, BrCH2CO-), 3.16 (t, 2H, -CONHCH2-), 2.22 (m, 1H, CH3CH2COOCH-, cyclohexyl), 1.80-2.10 (m, 4H, CH2-, cyclohexyl), 1.52 (m, 1H, NHCH2CH-, cyclohexyl), 1.49-1.37 (m, 2H, -CH2-, cyclohexyl), 1.24 (t, 3H, -COOCH2CH3), 1.08-0.92 (m, 2H, -CH2-, cyclohexyl). 13CNMR (CDCl3): delta=175.79 (BrCH2 CONH-), 165.57 (-COOCH2CH3), 60.23 (-COOCH2CH3), 45.96 (-COOCH-, cyclohexyl), 43.17 (-NHCH2CH-), 37.12 (-NHCH2 CH-, cyclohexyl), 29.68 (BrCH2CO-), 29.35 (-CH2-, cyclohexyl), 28.34 (-CH2-, cyclohexyl), 14.22 (-COOCH2 CH3). Anal. Calc. for C12H20BrNO3: C, 47.07; H, 6.58; N, 4.57. Found: C, 47.78; H, 6.85; N, 4.72 (purity>95%). FAB-MS (m/z): Calc. for C12H21BrNO3, 306.07 ([MH]+). Found: 306.20.
According to the analysis of related databases, 19878-18-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; Kim, Tae-Jeong; Chang, Yong Min; Kim, Hee-Kyung; Gu, Sung-Wook; US2013/231475; (2013); A1;,
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