Category: 1985-51-9

On December 15, 1997, Yoshii, Eiichi published an article.Application In Synthesis of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Cytotoxic effects of acrylates and methacrylates: relationships of monomer structures and cytotoxicity. And the article contained the following:

Thirty-nine acrylates and methacrylates that had been used in dental resin materials were evaluated by a cytotoxicity test, and the relationships between their structures and cytotoxicity were studied to predict cytotoxic levels of dental resin materials in order to develop new low-toxic resin materials. All the acrylates evaluated were more toxic than corresponding methacrylates. In both the acrylates and methacrylates, a hydroxyl group seemed to enhance cytotoxicity. Dimethacrylates with 14 or fewer oxyethylene chains showed similar cytotoxicity, while dimethacrylates with 23 oxyethylene chains showed lower cytotoxicity. The cytotoxicity ranking of monomers widely used in dental resin materials was bisGMA > urethane dimethacrylate (UDMA) > triethyleneglycol dimethacrylate (3G) > 2-hydroxyethyl methacrylate (HEMA) > Me methacrylate (MMA). In acrylates, methacrylates, and ethylmethacrylates with ether substituents, the lipophilicity of substituents affected their cytotoxicity, and an inverse correlation between IC50 and logP was observed These results will be useful in developing new resin materials with low toxic monomer compositions The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Application In Synthesis of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to dental acrylate methacrylate cytotoxicity structure, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Application In Synthesis of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

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Wen, Yueh Shan published an article in 1991, the title of the article was Fundamental study on microwave cured resin.HPLC of Formula: 1985-51-9 And the article contains the following content:

The composition, polymerization, and mech. properties, and the porosity of com. microwave cured (MC) resin, heat-cured (HA) resin, and the exptl. PMMA-MMA resins were investigated. The starting temperature for the polymerization of MC-resin was lower than that of HA-resin and its exothermic curve was the same as that of the exptl. resin with a redox catalyst. The starting temperature for the polymerization of the exptl. resins decreased with increasing the concentration of benzoyl peroxide (BPO) or by the use of the redox catalyst. The average mol. weights of the exptl. resins with BPO were lower than those of exptl. heat-curing resin, but the mol. weights increased by the use of the redox catalyst. The exptl. resins with BPO showed lower mech. strength than the exptl. heat-curing resin. However, the exptl. resins with the redox catalyst had a mech. strength equal to or higher than that of the exptl. heat-curing resin. The porosity increased with increasing the concentration of BPO, the microwave irradiation time and the thickness of cured product. However, it was suppressed by the use of the redox catalyst. Crosslinking agents of >5 weight% also suppressed the porosity. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).HPLC of Formula: 1985-51-9

The Article related to methacrylate denture resin microwave crosslinking, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.HPLC of Formula: 1985-51-9

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On January 31, 1978, Okubo, H.; Kato, M.; Kaetsu, I. published an article.Synthetic Route of 1985-51-9 The title of the article was Casting of organic glass by radiation-induced polymerization of glass-forming monomers at low temperatures. V. Casting and polymer properties of CR-39 modified monomer systems. And the article contained the following:

CR-39 [diethylene glycol bis(allyl carbonate)] [142-22-3]-polyfunctional monomer and CR-39-Me methacrylate-polyfunctional monomer, e.g., tetraethylene glycol dimethacrylate [64111-89-3], systems are suitable for casting by a 2-step polymerization method consisting of preirradiation and post-catalytic polymerization The systems could be cast in a much shorter time cycle than the conventional catalytic method with no optical strain. The phys. properties of the cast polymer, e.g., impact and heat resistance, were sufficient for practical use. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Synthetic Route of 1985-51-9

The Article related to casting polymerization diethylene glycol derivative, gamma irradiation casting organic glass, Synthetic High Polymers: Reactions Of Monomers and other aspects.Synthetic Route of 1985-51-9

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On December 31, 1989, Kawai, Keiji; Torii, Mitsuo; Tsuchitani, Yasuhiko published an article.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Effect of several resin monomers on water insoluble glucan formation by glucosyltransferase of Streptococcus sobrinus. And the article contained the following:

A possible mechanism by which more plaque accumulate on composite resins than on any other restorative materials was investigated by clarifying the effects of several monomers on the glycosyltransferase activity from S. sobrinus. In the individual resin monomers, di-, tri-, and tetra-ethylene glycol dimethacrylate (2G, 3G, and 4G), Bis-GMA and UDMA showed a stimulatory tendency of water insoluble glucan (WIG) formation. However, ethylene glycol dimethacrylate (1G), polyethylene glycol dimethacrylate (9G and 14G, and MMA diminished the synthesis of water soluble glucan as the concentration of monomers was increased. In addition, the eluate from exptl. resin consisted of 1G and Bis-GMA decreased the production of WIG when compared to that from 3G and Bis-GMA-based resin. Thus, it was possible to develop a composite resin which inhibits plaque accumulation by using some antienzymic monomers. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to dental composite plaque antienzymic monomer, glycosyltransferase plaque dental composite monomer, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

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On May 31, 2010, Perez-Garrido, Alfonso; Helguera, Aliuska Morales; Rodriguez, Francisco Giron; Cordeiro, M. Natalia D. S. published an article.Electric Literature of 1985-51-9 The title of the article was QSAR models to predict mutagenicity of acrylates, methacrylates and α, β-unsaturated carbonyl compounds. And the article contained the following:

The purpose of this study is to develop a quant. structure-activity relationship (QSAR) model that can distinguish mutagenic from nonmutagenic species with α,β-unsaturated carbonyl moiety using two endpoints for this activity, i.e. Ames test and mammalian cell gene mutation test, and also to gather information about the mol. features that most contribute to eliminate the mutagenic effects of these chems. Two data sets were used for modeling the two mutagenicity endpoints: (1) Ames test and (2) mammalian cells mutagenesis. The former comprised 220 mols., while the latter comprised 48 substances, ranging from acrylates and methacrylates to α,β-unsaturated carbonyl compounds The QSAR models were developed by applying linear discriminant anal. (LDA) along with different sets of descriptors computed using the DRAGON software. For both endpoints, there was a concordance of 89% in the prediction and 97% confidentiality by combining the three models for the Ames test mutagenicity. We have also identified several structural alerts to assist the design of new monomers. These individual models and especially their combination are attractive from the point of view of mol. modeling and could be used for the prediction and design of new monomers that do not pose a human health risk. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Electric Literature of 1985-51-9

The Article related to qsar model mutagenicity acrylate methacrylate unsaturated carbonyl compound, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Electric Literature of 1985-51-9

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On April 30, 2008, Johannsen, F. R.; Vogt, Barbara; Waite, Maureen; Deskin, Randy published an article.Recommanded Product: 1985-51-9 The title of the article was Mutagenicity assessment of acrylate and methacrylate compounds and implications for regulatory toxicology requirements. And the article contained the following:

Esters of acrylic acid and methacrylic acid, more commonly known as acrylates and methacrylates, resp., are key raw materials in the coatings and printing industry, with several of its chem. class used in food packaging. The results of over 200 short-term in vitro and in vivo mutagenicity studies available in the open literature have been evaluated. Despite differences in acrylate or methacrylate functionality or in the number of functional groups, a consistent pattern of test response was seen in a typical regulatory battery of mutagenicity tests. No evidence of point mutations was observed when acrylic acid or over 60 acrylates and methacrylates were investigated in Salmonella bacterial tests or in hprt mutation tests mammalian cells, and no evidence of a mutagenic effect was seen when tested in whole animal clastogenicity and/or aneuploidy (chromosomal aberration/micronucleus) studies. Consistent with the in vivo testing results, acrylic acid exhibited no evidence of carcinogenicity in chronic rodent cancer bioassays. In contrast, acrylic acid and the entire acrylate and methacrylate chem. class produced a consistently pos. response when tested in the mouse lymphoma assay and/or other in vitro mammalian cell assays designed to detect clastogenicity. The biol. relevance of this in vitro response is questioned based on the non-concordance of in vitro results with those of in vivo studies addressing the same mutagenic endpoint (clastogenicity). Thus, in short-term mutagenicity tests, the acrylates and methacrylates behave as a single chem. category, and genotoxicity behavior of a similar chem. can be predicted with confidence by inclusion within this chem. class, thus avoiding unnecessary testing. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 1985-51-9

The Article related to mutagenicity acrylate methacrylate toxicol genotoxicity, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Recommanded Product: 1985-51-9

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Ester – Wikipedia,
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On January 31, 2010, Perez-Garrido, Alfonso; Helguera, Aliuska Morales; Lopez, Gabriel Caravaca; Cordeiro, M. Natalia D. S.; Escudero, Amalio Garrido published an article.Application of 1985-51-9 The title of the article was A topological substructural molecular design approach for predicting mutagenesis end-points of α , β -unsaturated carbonyl compounds. And the article contained the following:

Chem. reactive, α, β -unsaturated carbonyl compounds are common environmental pollutants able to produce a wide range of adverse effects, including, e.g., mutagenicity. This toxic property can often be related to chem. structure, in particular to specific mol. substructures or fragments (alerts), which can then be used in specialized software or expert systems for predictive purposes. In the past, there have been many attempts to predict the mutagenicity of α, β -unsaturated carbonyl compounds through quant. structure activity relationships (QSAR) but considering only one exclusive endpoint: the Ames test. Besides, even though those studies give a comprehensive understanding of the phenomenon, they do not provide substructural information that could be useful forward improving expert systems based on structural alerts (SAs). This work reports an evaluation of classification models to probe the mutagenic activity of α, β -unsaturated carbonyl compounds over two endpoints – the Ames and mammalian cell gene mutation tests – based on linear discriminant anal. along with the topol. Substructure mol. (TOPS-MODE) approach. The obtained results showed the better ability of the TOPS-MODE approach in flagging structural alerts for the mutagenicity of these compounds compared to the expert system TOXTREE. Thus, the application of the present QSAR models can aid toxicologists in risk assessment and in prioritizing testing, as well as in the improvement of expert systems, such as the TOXTREE software, where SAs are implemented. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Application of 1985-51-9

The Article related to unsaturated carbonyl compound mutagenicity tops mode qsar, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Application of 1985-51-9

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On September 30, 1984, Waegemaekers, T. H. J. M.; Bensink, M. P. M. published an article.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Nonmutagenicity of 27 aliphatic acrylate esters in the Salmonella microsome test. And the article contained the following:

The mutagenicity of 27 acrylate esters was assessed in the Salmonella/microsome assay. None of the acrylate esters appeared to be mutagenic in the standard Ames assay with TA 1535, 1537, 1538, 98, and 100 both with and without Aroclor 1254 or phenobarbital-induced S9 mix. A liquid incubation assay of methyl methacrylate  [80-62-6], Me acrylate  [96-33-3], Bu acrylate  [141-32-2], and hexyl acrylate  [2499-95-8] with TA 100, neither gave any indication of mutagenic activity. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to acrylate ester mutagenicity, methacrylate ester mutagenicity, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahn, Dongchan published an article in 2003, the title of the article was Improved self-priming silicone adhesives through selective interface enrichment.Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) And the article contains the following content:

The interplay of the addition cure reactions and adhesion promoter (AP) migration was examined in a hydrosilylation-cured PDMS network modified with a model AP (neopentylglycol dimethacrylate). A combination of thermal anal. by differential scanning calorimetry (DSC) and Raman microscopy was used to demonstrate the desired order of reactivity. Surface anal. by attenuated total reflectance IR spectroscopy and XPS confirms significant levels of AP enrichment at both the substrate and air interfaces of resulting cured silicone slabs. The anal. methods of DSC and Raman microscopy were combined to provide direct evidence of a sequential cure mechanism, whereby the siloxane network forms before a methacrylate-functional adhesion promoter is cured into the matrix. Surface compositional profiles by ATR-IR microscopy and XPS have provided direct evidence of AP enrichment at interfaces in an addition cured silicone matrix. The resulting understanding can be exploited to develop systems with tailored interfaces for in-situ surface modification and control of a range of interface-dependent properties such as adhesion or release. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to polysiloxane adhesive adhesion promoter interface enrichment, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

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On October 31, 1984, Bjoerkner, Bert published an article.Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was The sensitizing capacity of multifunctional acrylates in the guinea pig. And the article contained the following:

The sensitizing capacity of multifunctional acrylates and their cross-reactivity patterns were investigated with the guinea pig maximization test. 1,4-Butanediol diacrylate  [1070-70-8] and 1,6-hexanediol diacrylate  [13048-33-4] were moderate to strong sensitizers and they probably cross-react with each other. The n-ethylene glycol diacrylates and methacrylates tested were weak and nonsensitizers. Tripropylene glycol diacrylate  [94120-00-0] was a moderate and neopentyl glycol diacrylate  [2223-82-7] a strong sensitizer, whereas neopentyl glycol dimethacrylate  [1985-51-9] was a nonsensitizer. The com. PETA is a mixture of pentaerythritol tri- [3524-68-3] and tetraacrylate [4986-89-4] (PETA 3 and PETA 4, resp.). PETA 3 is a much stronger sensitizer than PETA 4. Simultaneous reactions were seen between PETA 3, PETA 4 and trimethylolpropane triacrylate (TMPTA) [15625-89-5]. The oligotriacrylate  [101661-95-4] is a moderate sensitizer, but no concomitant reactions were seen with PETA 3, PETA 4 or TMPTA. Of multifunctional acrylates tested, the di- and triacrylic compounds, should be regarded as potent sensitizers. The methacrylate multifunctional acrylic compounds were weak or nonsensitizers. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to acrylate sensitization, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

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Ester – Wikipedia,
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