Category: 19788-49-9

Meng, Qi published the artcileQuantification and odor contribution of volatile thiols in Japanese soy sauce, Related Products of esters-buliding-blocks, the publication is Food Science and Technology Research (2012), 18(3), 429-436, database is CAplus.

Three compounds of volatile thiols, 2-furanmethanethiol (2FM) with a strong roast coffee aroma, benzenemethanethiol (BM) with a strong empyreumatic aroma reminiscent of smoke and Et 2-mercaptopropionate (ET2MP) with a tropical fruit-like aroma, were identified for the first time in four types of heat-treated soy sauce and raw soy sauce. 2FM, BM and ET2MP were present in these soy sauce samples at considerably higher concentrations than their perception thresholds. Their concentrations also increased when the raw soy sauce was heated for pasteurization. A triangle test on the raw soy sauce and heat-treated soy sauce showed that the aroma of the raw soy sauce became similar to that of the heat-treated soy sauce after the addition of the three volatile thiols to the raw soy sauce. The volatile thiols thus contributed to the aroma of heat-treated soy sauce.

Food Science and Technology Research published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kumar, Ish published the artcileA Thioesterase for Chemoselective Hydrolysis of S-Acyl Sulfanylalkanoates, Synthetic Route of 19788-49-9, the publication is Organic Letters (2001), 3(2), 283-285, database is CAplus and MEDLINE.

A thioesterase, isolated from a strain of Alcaligenes sp. ISH108, chemoselectively hydrolyzes the thiol ester moiety of S-acyl sulfanylalkanoates. The application of the enzyme has been demonstrated in the preparation of the antihypertensive agent captopril.

Organic Letters published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Wengang published the artcileVisible-Light-Induced Selective Defluoroborylation of Polyfluoroarenes, gem-Difluoroalkenes, and Trifluoromethylalkenes, Formula: C5H10O2S, the publication is Angewandte Chemie, International Edition (2020), 59(10), 4009-4016, database is CAplus and MEDLINE.

Fluorinated organoboranes serve as versatile synthetic precursors for the preparation of value-added fluorinated organic compounds Recent progress has been mainly focused on the transition-metal catalyzed defluoroborylation. Herein, we report a photocatalytic defluoroborylation platform through direct B-H activation of N-heterocyclic carbene boranes, through the synergistic merger of a photoredox catalyst and a hydrogen atom transfer catalyst. This atom-economic and operationally simple protocol has enabled defluoroborylation of an extremely broad scope of multifluorinated substrates including polyfluoroarenes, gem-difluoroalkenes, and trifluoromethylalkenes in a highly selective fashion. Intriguingly, the defluoroborylation protocol can be transition-metal free, and the regioselectivity obtained is complementary to the reported transition-metal-catalysis in many cases.

Angewandte Chemie, International Edition published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C4H10OS, Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kolarevic, Ana published the artcileSynthesis and DNase I inhibitory properties of some 4-thiazolidinone derivatives, Synthetic Route of 19788-49-9, the publication is Journal of Cellular Biochemistry (2019), 120(1), 264-274, database is CAplus and MEDLINE.

Twelve new thiazolidinones were synthesized and, together with 41 previously synthesized thiazolidinones, evaluated for inhibitory activity against DNase I (DNase I) in vitro. Ten compounds inhibited com. bovine pancreatic DNase I with an IC50 below 200 μM and showed to be more potent DNase I inhibitors than crystal violet (IC50 = 365.90 ± 47.33 μM), used as a pos. control. Moreover, three compounds were active against DNase I in rat liver homogenate, having an IC50 below 200 μM. (3-Methyl-1,4-dioxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (41) exhibited the most potent DNase I inhibition against both com. and rat liver DNase I with IC50 values of 115.96 ± 11.70 and 151.36 ± 15.85 μM, resp. Site Finder and mol. docking defined the thiazolidinones interactions with the most important catalytic residues of DNase I, including the H-acceptor interaction with residues His 134 and His 252 and/or H-donor interaction with residues Glu 39 and Asp 168. The three most active compounds against both com. and rat liver DNase I (31, 38, and 41) exhibited favorable physico-chem., pharmacokinetic, and toxicol. properties. These observations could be utilized to guide the rational design and optimization of novel thiazolidinone inhibitors. Thiazolidinones as novel DNase I inhibitors could have potential therapeutic applications due to the significant involvement of DNase I in the pathophysiol. of many disease conditions.

Journal of Cellular Biochemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lee, Alice published the artcileGeneral Solid-Phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is Journal of the American Chemical Society (1999), 121(43), 9907-9914, database is CAplus.

A general method has been developed for the expedient solid-phase synthesis of ketone-based cysteine protease inhibitors. The synthesis approach was designed to allow the introduction of diverse functionality at all variable sites about the ketone carbonyl using readily available precursors. The chloromethyl ketone scaffold is attached to the solid support through the newly developed hydrazine linker. Successful nucleophilic displacement of the support-bound α-chloro hydrazones with carboxylates, thiolates, and amines provides entry to the acyloxymethyl, mercaptomethyl, and amidomethyl ketone classes of cysteine protease inhibitors. Further transformations followed by cleavage from support provides the fully substituted ketone products in 40-100% overall yields after release from support. Significantly, racemization of the α-stereocenter does not occur during loading onto support, nucleophilic displacement, or cleavage from support.

Journal of the American Chemical Society published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Junlei published the artcileVisible-light-mediated defluorinative cross-coupling of gem-difluoroalkenes with thiols, Computed Properties of 19788-49-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(74), 11103-11106, database is CAplus and MEDLINE.

A visible-light-mediated monofluoroalkenylation through defluorinative cross-coupling of gem-difluoroalkenes RR¹C=CF₂ [R = biphenyl-4-yl, 1-benzofuran-2-yl, 4-(trifluoromethyl)phenyl, etc.; R¹ = H, Ph, 3-(trifluoromethyl)phenyl, 4-methoxyphenyl, etc.; RR¹ = 9H-fluoren-9-yl, [2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy- 2,3-dihydro-1H-inden-1-yl]] with aryl, benzyl, and alkyl thiols R²SH (R² = cyclohexyl, 4-methoxyphenyl, 2-bromophenyl, etc.) has been reported. This novel strategy provides facile and efficient access to tri/tetra-substituted monofluoroalkenes RR¹C=C(F)SR² under mild reaction conditions with good functional group tolerance. Late-stage modification of natural products such as dehydrocholic acid and diosgenin indicated the synthetic potential of this S-H monofluoroalkenylation process.

Chemical Communications (Cambridge, United Kingdom) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C14H22O2, Computed Properties of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yamamoto, Takeshi published the artcileQuantitative structure-activity relationship study of N-(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbonyl)guanidines as potent Na/H exchange inhibitors, Safety of Ethyl 2-mercaptopropanoate, the publication is Chemical & Pharmaceutical Bulletin (2000), 48(6), 843-849, database is CAplus and MEDLINE.

The authors have previously reported that N-(4-isopropyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl)guanidine methanesulfonate salt (KB-R9032) is a potent and highly water-soluble Na/H exchange inhibitor. In a series of studies on Na/H exchange inhibitors, the authors designed and synthesized N-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbonyl)guanidines (I, R¹ = H, R² = H or Me and R³ = H, Me, Et, iso-Pr, Pr, Bu or pentyl) as more potent inhibitors with high water-solubility The design strategy for I was based on a quant. structure-activity relation (QSAR) study, involving the proportional relation between the biol. activity and hydrophobicity of the ring structure of N-(2H-benzo[1,4]oxazine-6-carbonyl)guanidines (II). As expected, I showed more potent activity than II. It was found by using the QSAR anal. that I were about five-fold more potent than II. The increase in potency of I well agreed with the authors previous QSAR anal. result. The most potent derivative was the methanesulfonate salt of the 4-iso-Pr derivative of I (IC₅₀=0.0091 μM). In addition to the in vitro study, the 4-iso-Pr derivative of I showed significant protective activity against ventricular fibrillation in a rat acute myocardial infarction model.

Chemical & Pharmaceutical Bulletin published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C19H21N3O3S, Safety of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Meng, Qi published the artcileFormation by yeast of 2-furanmethanethiol and ethyl 2-mercaptopropionate aroma compounds in Japanese soy sauce, Formula: C5H10O2S, the publication is Bioscience, Biotechnology, and Biochemistry (2014), 78(1), 109-114, database is CAplus and MEDLINE.

Two aroma compounds of volatile thiols, 2-furanmethanethiol (2FM) and Et 2-mercaptopropionate (ET2MP), were formed in five types of Japanese soy sauce during fermentation by yeast. The concentrations of 2FM and ET2MP in the soy sauce samples increased during alc. fermentation The concentrations of 2FM and ET2MP were higher in the soy sauce fermented by Zygosaccharomyces rouxii than in that fermented by Candida versatilis. The enantiomers of ET2MP were separated by gas chromatog. in a capillary column. The average enantiomeric ratio of ET2MP in the soy sauce was approx. 1:1. 2FM was formed by yeast in a medium prepared from cysteine and furfural, and cysteine is considered the key precursor of 2FM by yeast in soy sauce.

Bioscience, Biotechnology, and Biochemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rassadin, Valentin A. published the artcileAccess to a Wide Range of Sultams by Cyclodialkylation of α-Substituted Methanesulfonanilides, Synthetic Route of 19788-49-9, the publication is European Journal of Organic Chemistry (2012), 2012(26), 5028-5037, S5028/1-S5028/169, database is CAplus.

A wide range of five- and six-membered sultams bearing an α-ethoxycarbonyl-α-Me substituent or an α-aryl group (17 examples) were synthesized by the cyclodialkylation of α-substituted methanesulfonanilides with α,ω-dihaloalkanes in the presence of K₂CO₃ or under phase-transfer catalysis (PTC) conditions. Upon treatment with K₂CO₃ in N,N-dimethylformamide (DMF) or NaH in DMSO (DMSO), N-(2,3-dibromopropyl)-α-toluenesulfonanilides furnished different 1,3-diaryl-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxides in good to excellent yields (51-88 %, 16 examples). The 4-methoxyphenyl (PMP) group was easily removed from the sultam nitrogen atom by treatment of the corresponding bicyclic sultams with cerium(IV) ammonium nitrate in acetonitrile (71-84 % yield, 6 examples).

European Journal of Organic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tominaga, Takatoshi published the artcileRole of Certain Volatile Thiols in the Bouquet of Aged Champagne Wines, Application In Synthesis of 19788-49-9, the publication is Journal of Agricultural and Food Chemistry (2003), 51(4), 1016-1020, database is CAplus and MEDLINE.

A method for the specific extraction of volatile thiols by use of p-hydroxymercuribenzoate has made it possible to identify certain flavor-active volatile thiols in Champagne wines. Benzenemethanethiol, 2-furanmethanethiol, and Et 3-mercaptopropionate were present in these wines at concentrations considerably higher than their perception thresholds. Their concentrations increased gradually in proportion to the bottle aging period and sharply as a result of disgorging. The contribution of these volatile thiols to the empyreumatic nuances of the bouquet of aged Champagne wines was demonstrated for the 1st time.

Journal of Agricultural and Food Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C7H12ClNO, Application In Synthesis of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics