Category: 19788-49-9

Cai, Yanyao published the artcileAccess to Functionalized E-Allylsilanes and E-Alkenylsilanes through Visible-Light-Driven Radical Hydrosilylation of Mono- and Disubstituted Allenes, Quality Control of 19788-49-9, the publication is Organic Letters (2019), 21(24), 9836-9840, database is CAplus and MEDLINE.

A visible-light-driven radical hydrosilylation of allene was achieved by using eosin Y as the photocatalyst, with thiol and base as additives. Depending on allenes, two types of adducts with E-selectivity were obtained. Monosubstituted nonarylated allenes reacted to give linear E-allylsilanes, while 1,3-disubstituted electron-deficient allenes afforded E-alkenylsilanes. A radical mechanism is proposed to account for the chemo-, regio-, and stereoselective formation of these functionalized Si-containing compounds

Organic Letters published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Quality Control of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Guoqing published the artcileSynthesis of Cyclopentenes, Pyrroles, and Thiophenes via a Sequence of Propargyl-Allenyl Isomerizations, Michael Additions, and Intramolecular Wittig Reactions, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is Journal of Organic Chemistry (2014), 79(22), 10867-10872, database is CAplus and MEDLINE.

Allenylphosphonium species, reactive Michael acceptors, could be generated from simple, readily available propargylphosphonium salts through propargyl-allenyl isomerization. We developed an efficient synthesis for cyclopentenes, pyrroles, and thiophenes via a sequence of propargyl-allenyl isomerizations, Michael additions, and intramol. Wittig reactions.

Journal of Organic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C8H7N3, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Zhanguo published the artcileParallel solution-phase synthesis of 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1λ⁶-benzo[1,4]thiazin-3-one derivatives from 1,5-difluoro-2,4-dinitrobenzene, SDS of cas: 19788-49-9, the publication is Journal of Combinatorial Chemistry (2007), 9(4), 652-660, database is CAplus and MEDLINE.

This paper discusses the synthesis of privileged structures 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1λ⁶-benzo[1,4]thiazin-3-one derivatives in a parallel solution-phase manner using 1,5-difluoro-2,4-dinitrobenzene. Each scaffold possesses four diversity points. A cheap and efficient oxidant, urea-hydrogen peroxide (UHP), was applied for the introduction of the sulfone group. The intramol. cyclization to 1,1-dioxo-1,4-dihydro-2H-1λ⁶-benzo[1,4]thiazin-3-one was achieved by microwave assistance or the use of an inorganic base.

Journal of Combinatorial Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C6H4ClNO2, SDS of cas: 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chan, Justin W. published the artcileThe nucleophilic, phosphine-catalyzed thiol-ene click reaction and convergent star synthesis with RAFT-prepared homopolymers, COA of Formula: C5H10O2S, the publication is Polymer (2009), 50(14), 3158-3168, database is CAplus.

The synthesis of 3-arm star polymers from reversible addition-fragmentation chain transfer (RAFT)-prepared precursor homopolymers in combination with thiol-ene click chem. is described. Homopolymers of Bu acrylate and N,N-diethylacrylamide were prepared with 1-cyano-1-methylethyl dithiobenzoate and 2,2′-azobis(2-methylpropionitrile) yielding materials with polydispersity indexes (M_w/M_n) ≤ 1.18 and controlled mol. weights as determined by a combination of NMR spectroscopy, size exclusion chromatog. (SEC), and matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Subsequent one-pot reaction of homopolymer, hexylamine (HexAM), dimethylphenylphosphine (DMPP), and trimethylolpropane triacrylate (TMPTA) results in cleavage of the thiocarbonylthiol end-group (by HexAM) of the homopolymer yielding a macromol. thiol that undergoes DMPP-initiated thiol-Michael addition to TMPTA yielding 3-arm star polymers. The presence of DMPP is demonstrated to serve an important second role in effectively suppressing the presence of any polymeric disulfide as determined by SEC. Such phosphine-mediated thiol-ene reactions are shown to be extremely rapid, as verified by a combination of FTIR and NMR spectroscopies, with complete consumption of the C=C bonds occurring in a matter of min. MALDI-TOF MS and SEC were used to verify the formation of 3-arm stars. A broadening in the mol. weight distribution (M_w/M_n ∼ 1.35) was observed by SEC that was attributed to the presence of residual homopolymer and possibly 2-arm stars formed from trimethylolpropane diacrylate impurity. Interestingly, the MALDI anal. also indicated the presence of 1- and 2-arm species most likely formed from the fragmentation of the parent 3-arm star during anal. Finally, a control experiment verified that the consumption of C=C bonds does not occur via a radical pathway.

Polymer published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, COA of Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yildirim, Hatice published the artcileNatural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure-activity relationship, activity profile, mode of action, and molecular docking, Name: Ethyl 2-mercaptopropanoate, the publication is RSC Advances (2022), 12(32), 20507-20518, database is CAplus and MEDLINE.

In an attempt to develop effective and potentially active antibacterial and/or antifungal agents, we designed, synthesized, and characterized thiolated CoQ analogs (CoQ1-8) with an extensive antimicrobial study. The antimicrobial profile of these analogs was determined using four Gram-neg. bacteria, three Gram-pos. bacteria, and three fungi. Because of the fact that the thiolated CoQ analogs were quite effective on all tested Gram-pos. bacterial strains, including Staphylococcus aureus (ATCC 29213) and Enterococcus faecalis (ATCC 29212), the first two thiolated CoQ analogs emerged as potentially the most desirable ones in this series. Importantly, after the evaluation of the antibacterial and antifungal activity, we presented an initial structure-activity relationship for these CoQ analogs. In addition, the most promising thiolated CoQ analogs (CoQ1 and CoQ2) having the lowest MIC values on all tested Gram-pos. bacterial strains, were further evaluated for their inhibition capacities of biofilm formation after evaluating their in vitro potential antimicrobial activity against each of 20 clin. obtained resistant strains of Gram-pos. bacteria. CoQ1 and CoQ2 exhibited potential mol. interactions with S. aureus DNA gyrase in addition to excellent pharmacokinetics and lead-likeness profiles. Our findings offer important implications for a potential antimicrobial drug candidate, in particular for the treatment of infections caused by clin. resistant MRSA isolates.

RSC Advances published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C24H20Ge, Name: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Franzini, Maurizio published the artcileTriazolopyridazine LRRK2 kinase inhibitors, Safety of Ethyl 2-mercaptopropanoate, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(7), 1967-1973, database is CAplus and MEDLINE.

Leucine-rich repeat kinase 2 (LRRK2) has been implicated in the pathogenesis of Parkinson’s disease (PD). Inhibition of LRRK2 kinase activity is a therapeutic approach that may lead to new treatments for PD. Herein we report the discovery of a series of [1,2,4]triazolo[4,3-b]pyridazines that are potent against both wild-type and mutant LRRK2 kinase activity in biochem. assays and show an unprecedented selectivity towards the G2019S mutant. A structural rational for the observed selectivity is proposed.

Bioorganic & Medicinal Chemistry Letters published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Safety of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yu, Hai-Zhu published the artcileQuantum-Chemical Predictions of pK_a‘s of Thiols in DMSO, Related Products of esters-buliding-blocks, the publication is Journal of Physical Chemistry A (2014), 118(3), 606-622, database is CAplus and MEDLINE.

The deprotonation of thiols (on the S-H bond) is widely involved in organic and bio-organic reactions. With the aid of d. functional theory (DFT) calculations, the present study focuses on predicting the pK_a‘s of thiols. Efforts were first put in searching for an appropriate computational method. To achieve this goal, the accuracy of 13 different DFT functionals (i.e., B3LYP, BB1K, PBE, M06, M05, M06-2X, M06-L, M05-2X, TPSS, MPW1K, MPWB1K, MPW3LYP, TPSSLYP1W) and 6 different total electron basis sets (6-31G-(d), 6-31+G-(d), 6-31+G-(d,p), 6-311+G-(d,p), 6-311++G-(d,p), 6-311++G-(2df,2p)) (with DMSO solvent and SMD solvation model) were examined The M06-2X/6-311++G-(2df,2p) (M1) method was found to give the best performance in reproducing the reported 16 pK_a‘s of thiols, with a standard deviation (SD) of about 0.5 pK_a unit. Meanwhile, the M1 method was found to be excellent in reproducing the gas phase Gibbs free energies of 17 thiols, providing extra evidence for the reliability of the M1 method in treating thiol systems. On this basis, M1 was then used to predict the pK_a‘s of 291 thiols whose exptl. pK_a values remain unknown. Accordingly, the scope of pK_a‘s of different thiols was constructed.

Journal of Physical Chemistry A published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C12H17NO2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cao, Jilei published the artcileMetal-free hydrogen evolution cross-coupling enabled by synergistic photoredox and polarity reversal catalysis, Application of Ethyl 2-mercaptopropanoate, the publication is Green Chemistry (2021), 23(22), 8988-8994, database is CAplus.

A synergistic combination of photoredox and polarity reversal catalysis enabled a hydrogen evolution cross-coupling of silanes with H₂O, alcs., phenols, and silanols, which afforded the corresponding silanols, monosilyl ethers, and disilyl ethers, resp., in moderate to excellent yields. The dehydrogenative cross-coupling of Si-H and O-H proceeded smoothly with broad substrate scope and good functional group compatibility in the presence of only an organophotocatalyst 4-CzIPN and a thiol HAT catalyst, without the requirement of any metals, external oxidants and proton reductants, which is distinct from the previously reported photocatalytic hydrogen evolution cross-coupling reactions where a proton reduction cocatalyst such as a cobalt complex is generally required. Mechanistically, a silyl cation intermediate is generated to facilitate the cross-coupling reaction, which therefore represents an unprecedented approach for the generation of silyl cation via visible-light photoredox catalysis.

Green Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Application of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nguyen, Duc H. published the artcileSolid-Supported MADIX Polymerization of Vinyl Acetate, Category: esters-buliding-blocks, the publication is Macromolecules (Washington, DC, United States) (2008), 41(19), 7071-7078, database is CAplus.

A simple, one-pot synthesis of a surface-tethered MADIX agent was established via the reaction of 1,1′-thiocarbonyl diimidazole (TCDI) with a thiol, followed by reaction with the hydroxyl groups of a Wang resin. The supported RAFT agent was used to control the polymerization of vinyl acetate in toluene. The amount of surface-bound polymer was found to greatly increase with increasing content of solid MADIX agent, reaching values of almost 80%. The grafted PVAc chains were cleaved from the Wang resin support via radical reaction with tert-amyl peroxy acetate (TAPA), and the mol. weight distributions exhibited the typical shape of polymers formed via a well-controlled living radical polymerization (LRP), with the free polymers showing a slightly higher mol. weight than the living fraction. The M_n values of both living polymer fraction (surface-bound polymer) and dead polymer (free polymer) increased steadily with monomer conversion-as expected for a well controlled MADIX polymerization-and were in good agreement with the theor. mol. weights PDI values of both polymer fractions scatter around 1.5, with a slight tendency of narrower mol. weight distributions of the living polymer, which shows a min. value of 1.43. Addition of free MADIX agent to the solution phase led to a decrease in PDI values of both free and bound polymer, and the exptl. molar masses were in good agreement with theor. predictions.

Macromolecules (Washington, DC, United States) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Qin, Qixue published the artcileA metal-free desulfurizing radical reductive C-C coupling of thiols and alkenes, Quality Control of 19788-49-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(71), 10583-10586, database is CAplus and MEDLINE.

An intermol. reductive C-C coupling of electrophilic alkyl radicals and alkenes was developed. Thiols were used as both hydrogen-donating reagents and alkyl radical precursors in the presence of tri-Et phosphite and radical initiator. A wide range of alkenes, including styrenes and aliphatic olefins were well tolerated in this transformation. Mechanistic studies indicated that a phosphite promoted radical desulfurization of thiols to accessed electrophilic alkyl radicals and a radical chain propagation process may be involved in this transformation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Quality Control of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics