Adding a certain compound to certain chemical reactions, such as: 19397-74-1, name is Ethyl 4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19397-74-1, Application In Synthesis of Ethyl 4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylate
The compound 4,5-dihydronaphthalene [1,2-b]thiophene-2-carboxylic acid ethyl ester (0.5 g, 1.94 mmol) and benzoyl peroxide (5 mg) obtained by the method of 14b) were dissolved in dry. In a solution of CC14 (8 mL), NBS (0.52 g, 2.9 mmol) was. The reaction solution was refluxed while being irradiated with a 200 W fluorescent lamp, and the generated hydrogen bromide gas was purged with a nitrogen stream, and the reaction was further refluxed for 1 hour. The reaction was completed to completion by TLC, and the reaction mixture was cooled, filtered and concentrated to give a crude product.With ethyl acetate /Recrystallization from n-hexane gave a yellow solid, 0.43 g.The yield was 87.2%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Peking University; Jiangsu Enhua Pharmaceutical Co., Ltd.; Zhang Liangren; Wang Kewei; Yang Taoyi; Xue Yu; Li Qing; Zhang Guisen; (35 pag.)CN108727416; (2018); A;,
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