Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19376-57-9, name is Methyl 4,4,4-trichlorobutanoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 19376-57-9
To a stirred solution of methyl 4,4,4-trichlorobutanoate 2 (1.35 g, 6.57 mmol) in DCM (30 mL) at -78 C was added DIBAL-H (6.57 mL, 6.57 mmol, 1.0 M in hexanes) at a rate of 1.0 mL/min. The reaction mixture was stirred at -78 C for 1 h. After successive addition of MeOH (7 mL), HC1 (25 mL, 1 M) and Rochelle salt solution (25 mL, 1 M), the reaction mixture was stirred at room temperature for another 1 h. The separated organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The crude residue was purified by silica gel flash chromatography eluting with hexanes/EtOAc (20:1) to afford 4,4,4-trichlorobutanal 3 (1.15 g, 5.78 mmol) as a colourless oil in a yield of 88 %. ?H NMR (400 MHz, CDC13) S9.85 (br. s., 1H), 3.03-3.11 (m, 2H), 2.96-3.02 (m, 2H); ?3CNMR(100 MHz, CDC13) S 198.5, 98.9, 47.5, 41.2.
According to the analysis of related databases, 19376-57-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRITISH COLUMBIA CANCER AGENCY BRANCH; THE UNIVERSITY OF BRITISH COLUMBIA; YAN, Luping; ANDERSEN, Raymond, J.; SADAR, Marianne, Dorothy; MAWJI, Nasrin, R.; BANUELOS, Carmen, Adriana; WO2015/184393; (2015); A1;,
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