Category: 193290-19-6

193290-19-6, name is Methyl 2-(4-bromo-2-fluorophenyl)acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C9H8BrFO2

Step B: To a solution of intermediate 1 (10.35 g, 0.042 mol) in 210 mL THF at -70 C was added n-BuLi (1.6 M in hexane, 28 mL, 0.045 mol). The mixture was stirred at -70 C for 1 h before a solution of 4-bromo-2-fluorophenyl acetic acid methyl ester (10.55 g, 0.043 mol) in 10 mL THF was added. The reaction mixture was allowed to warm to room temperature and stirred for another Ih. The reaction was quenched with ice water (200 mL), and the product was extracted with CH2Cl2. The extracts were dried over MgSO4, filtered, and concentrated. Column chromatography (2% EtOAc/PE) of the residue afforded the title compound.

The synthetic route of 193290-19-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2008/51404; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 193290-19-6 as follows. name: Methyl 2-(4-bromo-2-fluorophenyl)acetate

To a solution of methyl 2-(4-bromo-2-fluorophenyl) acetate (1 g, 4.05 mmol) in toluene/THF H20 (15 mL, v/v/v=2/2/l ) were added 2-methylpyridin-3-ylboronic acid (870 mg, 3.97 mmol), AcO (790 mg, 8.05 mmol) and PdCl2(dppf) (222 mg, 0.31 mmol) under nitrogen. The reaction mixture was stirred at 90C for 15 h. The reaction mixture was filtered, the filtrate was washed with water, extracted with EtOAc (2 x 10 mL). The combined layers were washed with brine, dried over Na2S04 and concentrated. The residue was purified by column chromatography on silica gel eluted with 0- 10% EtOAc in petroleum ether to afford the desired product (0.9 , 86%). LCMS m/z 260 (M+l )+.

According to the analysis of related databases, 193290-19-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio, G.; WO2013/43232; (2013); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 193290-19-6, name is Methyl 2-(4-bromo-2-fluorophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Methyl 2-(4-bromo-2-fluorophenyl)acetate

A suspension of methyl (4-bromo-2-fluorophenyl)acetate (5.5 g, 0.0223 mol; see step (v) above), Zn(CN)2 (1.79 g, 0.0156 mol) in dry DMF (30 mL) was purged with argon for 15 minutes before Pd(PPh3)4 (1.27 g, 0.0011 mol) was added. The resulting suspension was stirred at 800C overnight under a nitrogen atmosphere before the reaction was quenched with water and extracted with ethyl acetate. The organic layer was washed with water and brine and dried over sodium sulfate. Solvent evaporation under reduced pressure, followed by purification over silica gel (using 18% ethyl acetate in petroleum ether as eluent) gave the sub-title compound (3.6 g) as a pale yellow solid.

According to the analysis of related databases, 193290-19-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2007/69986; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics