Yang, Jianjing’s team published research in Advanced Synthesis & Catalysis in 2022-05-17 | 19241-24-8

Advanced Synthesis & Catalysis published new progress about Acetates Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Yang, Jianjing; Zeng, Ting; Yan, Kelu; Qin, Zonghui; Wen, Jiangwei published the artcile< Direct Synthesis of Alkylthioimidazoles: One-Pot Three-Component Cross-Coupling Mediated by Paired Electrolysis>, Synthetic Route of 19241-24-8, the main research area is isothiocyanate cyanoacetate haloalkane electrochem multicomponent cross coupling; alkylthioimidazole preparation.

The direct synthesis of alkylthioimidazoles was initially accomplished via a one-pot three-component cross-coupling mediated by a paired electrolysis strategy using non-activated chloroalkane as the alkylating agent. This protocol provides a straightforward method for the preparation of alkylthioimidazoles by employing water as the co-solvent at room temperature without any exogenous-oxidants and metal catalysts. Inactivated primary, secondary, tertiary haloalkanes and various isothiocyanates was compatible with the established conditions to obtain the corresponding products with a moderate yield. The mechanism of this one-pot three-component cross-coupling reaction undergoes a radical process mediated by paired electrolysis.

Advanced Synthesis & Catalysis published new progress about Acetates Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Yang’s team published research in Bioorganic & Medicinal Chemistry Letters in 2020-01-15 | 19241-24-8

Bioorganic & Medicinal Chemistry Letters published new progress about Anticoagulants. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, HPLC of Formula: 19241-24-8.

Shi, Yang; Pan, Bo-Wen; Li, Wen-Chao; Wang, Qing; Wu, Qiong; Pan, Meng; Fu, Hong-Zheng published the artcile< Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors>, HPLC of Formula: 19241-24-8, the main research area is isosteviol derivative preparation FXa inhibitor anticoagulant; FXa inhibitors; Isosteviol; Structural modification.

Firstly, a series of Isosteviol derivatives were synthesized and evaluated for FXa inhibitory activity. Among these compounds, the inhibitory activity of three compounds on FXa was better than that of Isosteviol. Secondly, surface plasmon resonance (SPR) assays were performed for selected compounds The three compounds have similar kinetic signatures, and affinity values were at μM level. Thirdly, two compounds displayed moderate-to-high anticoagulation activity and showed similar sensitivity to PT and aPTT. These findings will provide new insight into the exploration of FXa inhibition.

Bioorganic & Medicinal Chemistry Letters published new progress about Anticoagulants. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, HPLC of Formula: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Wei’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2019 | 19241-24-8

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyanation (isothio). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Feng, Wei; Zhang, Xing-Guo published the artcile< Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur>, Synthetic Route of 19241-24-8, the main research area is primary amine sodium bromodifluoroacetate sulfur copper iodide catalyst isothiocyanation; isothiocyanate preparation green chem.

A copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur in the absence of organophosphine was established. This approach represented a simple and efficient one-pot synthesis of isothiocyanates and features excellent functional group tolerance and the use of a cheap, safe and odorless sulfur source. This process could directly provided isothiocyanate analogous bioactive mols., thiocarbonyl-containing pesticides and facile construction of benzoxazole and benzimidazole frames.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyanation (isothio). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Lingling’s team published research in Organic & Biomolecular Chemistry in 2021 | 19241-24-8

Organic & Biomolecular Chemistry published new progress about Addition reaction. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Xiang, Lingling; Wu, Haiting; Liang, Yunshi; Deng, Huiying; He, Yiting; Xu, Qin; Zhang, Jing published the artcile< Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry>, SDS of cas: 19241-24-8, the main research area is methylenethiazoline amino preparation chemoselective; propargylamine isothiocyanate addition cyclization silver catalyst tandem reaction.

An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate RNCS (R = Ph, cyclohexyl, i-Pr, etc.) and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines I. This route features an unprecedented fast reaction rate with full conversion reached within 10 min at room temperature for aromatic isothiocyanates and excellent chemoselectivity for exocyclic products. The application of this strategy is further highlighted by the accelerated bioconjugation of propargylamine with fluorescein isothiocyanate (FITC) under Ag(I)-catalysis.

Organic & Biomolecular Chemistry published new progress about Addition reaction. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yunfei’s team published research in Organic Letters in 2022-07-22 | 19241-24-8

Organic Letters published new progress about Antitumor agents. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Hu, Yunfei; Chen, Li; Zou, Canlin; He, Jiangtao; Feng, Luanqi; Wu, Jia-Qiang; Chen, Wen-Hua; Hu, Jinhui published the artcile< Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization>, Application In Synthesis of 19241-24-8, the main research area is hydrazinopyridine isothiocyanate tetrabutylammonium iodide catalyst desulfurative cyclization; amino triazolo pyridine electrochem preparation.

An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity.

Organic Letters published new progress about Antitumor agents. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Yang’s team published research in Bioorganic & Medicinal Chemistry Letters in 2020-01-15 | 19241-24-8

Bioorganic & Medicinal Chemistry Letters published new progress about Anticoagulants. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, HPLC of Formula: 19241-24-8.

Shi, Yang; Pan, Bo-Wen; Li, Wen-Chao; Wang, Qing; Wu, Qiong; Pan, Meng; Fu, Hong-Zheng published the artcile< Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors>, HPLC of Formula: 19241-24-8, the main research area is isosteviol derivative preparation FXa inhibitor anticoagulant; FXa inhibitors; Isosteviol; Structural modification.

Firstly, a series of Isosteviol derivatives were synthesized and evaluated for FXa inhibitory activity. Among these compounds, the inhibitory activity of three compounds on FXa was better than that of Isosteviol. Secondly, surface plasmon resonance (SPR) assays were performed for selected compounds The three compounds have similar kinetic signatures, and affinity values were at μM level. Thirdly, two compounds displayed moderate-to-high anticoagulation activity and showed similar sensitivity to PT and aPTT. These findings will provide new insight into the exploration of FXa inhibition.

Bioorganic & Medicinal Chemistry Letters published new progress about Anticoagulants. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, HPLC of Formula: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Wei’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2019 | 19241-24-8

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyanation (isothio). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Feng, Wei; Zhang, Xing-Guo published the artcile< Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur>, Synthetic Route of 19241-24-8, the main research area is primary amine sodium bromodifluoroacetate sulfur copper iodide catalyst isothiocyanation; isothiocyanate preparation green chem.

A copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur in the absence of organophosphine was established. This approach represented a simple and efficient one-pot synthesis of isothiocyanates and features excellent functional group tolerance and the use of a cheap, safe and odorless sulfur source. This process could directly provided isothiocyanate analogous bioactive mols., thiocarbonyl-containing pesticides and facile construction of benzoxazole and benzimidazole frames.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyanation (isothio). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Lingling’s team published research in Organic & Biomolecular Chemistry in 2021 | 19241-24-8

Organic & Biomolecular Chemistry published new progress about Addition reaction. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Xiang, Lingling; Wu, Haiting; Liang, Yunshi; Deng, Huiying; He, Yiting; Xu, Qin; Zhang, Jing published the artcile< Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry>, SDS of cas: 19241-24-8, the main research area is methylenethiazoline amino preparation chemoselective; propargylamine isothiocyanate addition cyclization silver catalyst tandem reaction.

An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate RNCS (R = Ph, cyclohexyl, i-Pr, etc.) and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines I. This route features an unprecedented fast reaction rate with full conversion reached within 10 min at room temperature for aromatic isothiocyanates and excellent chemoselectivity for exocyclic products. The application of this strategy is further highlighted by the accelerated bioconjugation of propargylamine with fluorescein isothiocyanate (FITC) under Ag(I)-catalysis.

Organic & Biomolecular Chemistry published new progress about Addition reaction. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yunfei’s team published research in Organic Letters in 2022-07-22 | 19241-24-8

Organic Letters published new progress about Antitumor agents. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Hu, Yunfei; Chen, Li; Zou, Canlin; He, Jiangtao; Feng, Luanqi; Wu, Jia-Qiang; Chen, Wen-Hua; Hu, Jinhui published the artcile< Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization>, Application In Synthesis of 19241-24-8, the main research area is hydrazinopyridine isothiocyanate tetrabutylammonium iodide catalyst desulfurative cyclization; amino triazolo pyridine electrochem preparation.

An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity.

Organic Letters published new progress about Antitumor agents. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics