Category: 19241-24-8

Yao, Guangkai; Wang, Bing-Feng; Yang, Shuai; Zhang, Zhi-Xiang; Xu, Han-Hong; Tang, Ri-Yuan published the artcile< DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C-H sulfurization: a new route to 2-aminobenzothiazoles>, SDS of cas: 19241-24-8, the main research area is aryl isothiocyanate DMSO palladium bromide heterocyclization sulfurization tandem reaction; arylaminobenzothiazole preparation.

DMSO was found to activate arylisothiocyanates for self-nucleophilic addition A subsequent intramol. C-H sulfurization catalyzed by PdBr2 enable accessed to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C-H sulfurization of two isothiocyanates.

RSC Advances published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Siddiqui, Hina; Shafi, Sarah; Ali, Hamad; Musharraf, Syed Ghulam published the artcile< Synthesis and Erythroid Induction Activity of New Thiourea Derivatives>, Name: 4-tert-Butylphenylisothiocyanate, the main research area is thiourea fetal Hb erythroid; HbF induction effect; Thiourea derivatives; cytotoxicity; erythroid induction activity; sickle-cell anemia and β-thalassemia; β-thalassemia.

The erythroid induction potential of newly synthesized thiourea derivatives Thiourea derivatives 1-27 were synthesized by using environmentally friendly methods and new compounds 3, 10 and 22 The structures of synthesized derivatives were deduced by using various spectroscopic techniques. These derivatives were then evaluated for their erythroid induction using the human erythroleukemic K562 cell line, as a model. The benzidine-H2O2 assay was used to evaluate erythroid induction, while HbF expression was studied through immunocytochem. using the Anti-HbF antibody. Cytotoxicity of compounds 1-27 was also evaluated on mouse fibroblast 3T3 cell line and cancer Hela cell line using MTT assay. All the compounds (1-27) have not been reported for their erythroid induction activity previously. Compounds 1, 2, and 3 were found to be the potent erythroid inducing agents with % induction of 45± 6.9, 44± 5.9, and 41± 6.1, at 1.56, 0.78, and 0.78 μM concentrations, resp., as compared to untreated control (12 ± 1 % induction). Furthermore, compound 1, 2, and 3 significantly induced fetal Hb the expression up to 4.2-fold, 4.06-fold, and 3.52-fold, resp., as compared to untreated control. Moreover, the compounds 1-4, 6-9, 11, 12, 15, 17, 19, 22, 23, and 25 were found to be non-cytotoxic against the 3T3 cell line. This study signifies that the compounds reported here may serve as the starting point for the designing and development of new fetal Hb inducers for the treatment of beta-hemoglobinopathies.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Cytotoxicity. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Name: 4-tert-Butylphenylisothiocyanate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cerda, Matthew M.; Mancuso, Jenna L.; Mullen, Emma J.; Hendon, Christopher H.; Pluth, Michael D. published the artcile< Use of Dithiasuccinoyl-Caged Amines Enables COS/H2S Release Lacking Electrophilic Byproducts>, SDS of cas: 19241-24-8, the main research area is dithiasuccinoyl carbonyl sulfide hydrogen sulfide release; bioorganic chemistry; carbonyl sulfide; hydrogen sulfide; reactive sulfur species.

The enzymic conversion of carbonyl sulfide (COS) to hydrogen sulfide (H2S) by carbonic anhydrase has been used to develop self-immolating thiocarbamates as COS-based H2S donors to further elucidate the impact of reactive sulfur species in biol. The high modularity of this approach has provided a library of COS-based H2S donors that can be activated by specific stimuli. A common limitation, however, is that many such donors result in the formation of an electrophilic quinone methide byproduct during donor activation. As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS/H2S donor motifs, and that these groups release two equivalent of COS/H2S and uncage an amine payload under physiol. relevant conditions. Addnl., we demonstrate that COS/H2S release from this donor motif can be altered by electronic modulation and alkyl substitution. These insights are further supported by DFT investigations, which reveal that aryl and alkyl thiocarbamates release COS with significantly different activation energies.

Chemistry – A European Journal published new progress about Free energy of activation. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shim, Jae Ho; Nam, Si Hun; Kim, Byeong-Seon; Ha, Deok-Chan published the artcile< Organocatalytic asymmetric Michael addition of ketones to α, β-unsaturated nitro compounds>, Related Products of 19241-24-8, the main research area is ketone unsaturated nitro compound organocatalytic asym Michael addition.

An organic catalyst “”(R, R)-1,2-diphenylethylenediamine(DPEN) derivative”” was developed as a chiral bifunctional organocatalyst and applied for asym. Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-substituted thiourea catalyst in neutral condition provides high chem. yield and enantioselectivities (ee) (up to 96% yield, 98% ee).

Catalysts published new progress about Michael reaction catalysts, stereoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Related Products of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Guangkai; Wang, Bing-Feng; Yang, Shuai; Zhang, Zhi-Xiang; Xu, Han-Hong; Tang, Ri-Yuan published the artcile< DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C-H sulfurization: a new route to 2-aminobenzothiazoles>, SDS of cas: 19241-24-8, the main research area is aryl isothiocyanate DMSO palladium bromide heterocyclization sulfurization tandem reaction; arylaminobenzothiazole preparation.

DMSO was found to activate arylisothiocyanates for self-nucleophilic addition A subsequent intramol. C-H sulfurization catalyzed by PdBr2 enable accessed to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C-H sulfurization of two isothiocyanates.

RSC Advances published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Siddiqui, Hina; Shafi, Sarah; Ali, Hamad; Musharraf, Syed Ghulam published the artcile< Synthesis and Erythroid Induction Activity of New Thiourea Derivatives>, Name: 4-tert-Butylphenylisothiocyanate, the main research area is thiourea fetal Hb erythroid; HbF induction effect; Thiourea derivatives; cytotoxicity; erythroid induction activity; sickle-cell anemia and β-thalassemia; β-thalassemia.

The erythroid induction potential of newly synthesized thiourea derivatives Thiourea derivatives 1-27 were synthesized by using environmentally friendly methods and new compounds 3, 10 and 22 The structures of synthesized derivatives were deduced by using various spectroscopic techniques. These derivatives were then evaluated for their erythroid induction using the human erythroleukemic K562 cell line, as a model. The benzidine-H2O2 assay was used to evaluate erythroid induction, while HbF expression was studied through immunocytochem. using the Anti-HbF antibody. Cytotoxicity of compounds 1-27 was also evaluated on mouse fibroblast 3T3 cell line and cancer Hela cell line using MTT assay. All the compounds (1-27) have not been reported for their erythroid induction activity previously. Compounds 1, 2, and 3 were found to be the potent erythroid inducing agents with % induction of 45± 6.9, 44± 5.9, and 41± 6.1, at 1.56, 0.78, and 0.78 μM concentrations, resp., as compared to untreated control (12 ± 1 % induction). Furthermore, compound 1, 2, and 3 significantly induced fetal Hb the expression up to 4.2-fold, 4.06-fold, and 3.52-fold, resp., as compared to untreated control. Moreover, the compounds 1-4, 6-9, 11, 12, 15, 17, 19, 22, 23, and 25 were found to be non-cytotoxic against the 3T3 cell line. This study signifies that the compounds reported here may serve as the starting point for the designing and development of new fetal Hb inducers for the treatment of beta-hemoglobinopathies.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Cytotoxicity. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Name: 4-tert-Butylphenylisothiocyanate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cerda, Matthew M.; Mancuso, Jenna L.; Mullen, Emma J.; Hendon, Christopher H.; Pluth, Michael D. published the artcile< Use of Dithiasuccinoyl-Caged Amines Enables COS/H2S Release Lacking Electrophilic Byproducts>, SDS of cas: 19241-24-8, the main research area is dithiasuccinoyl carbonyl sulfide hydrogen sulfide release; bioorganic chemistry; carbonyl sulfide; hydrogen sulfide; reactive sulfur species.

The enzymic conversion of carbonyl sulfide (COS) to hydrogen sulfide (H2S) by carbonic anhydrase has been used to develop self-immolating thiocarbamates as COS-based H2S donors to further elucidate the impact of reactive sulfur species in biol. The high modularity of this approach has provided a library of COS-based H2S donors that can be activated by specific stimuli. A common limitation, however, is that many such donors result in the formation of an electrophilic quinone methide byproduct during donor activation. As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS/H2S donor motifs, and that these groups release two equivalent of COS/H2S and uncage an amine payload under physiol. relevant conditions. Addnl., we demonstrate that COS/H2S release from this donor motif can be altered by electronic modulation and alkyl substitution. These insights are further supported by DFT investigations, which reveal that aryl and alkyl thiocarbamates release COS with significantly different activation energies.

Chemistry – A European Journal published new progress about Free energy of activation. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shim, Jae Ho; Nam, Si Hun; Kim, Byeong-Seon; Ha, Deok-Chan published the artcile< Organocatalytic asymmetric Michael addition of ketones to α, β-unsaturated nitro compounds>, Related Products of 19241-24-8, the main research area is ketone unsaturated nitro compound organocatalytic asym Michael addition.

An organic catalyst “”(R, R)-1,2-diphenylethylenediamine(DPEN) derivative”” was developed as a chiral bifunctional organocatalyst and applied for asym. Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-substituted thiourea catalyst in neutral condition provides high chem. yield and enantioselectivities (ee) (up to 96% yield, 98% ee).

Catalysts published new progress about Michael reaction catalysts, stereoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Related Products of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cerda, Matthew M.; Mancuso, Jenna L.; Mullen, Emma J.; Hendon, Christopher H.; Pluth, Michael D. published the artcile< Use of Dithiasuccinoyl-Caged Amines Enables COS/H2S Release Lacking Electrophilic Byproducts>, SDS of cas: 19241-24-8, the main research area is dithiasuccinoyl carbonyl sulfide hydrogen sulfide release; bioorganic chemistry; carbonyl sulfide; hydrogen sulfide; reactive sulfur species.

The enzymic conversion of carbonyl sulfide (COS) to hydrogen sulfide (H2S) by carbonic anhydrase has been used to develop self-immolating thiocarbamates as COS-based H2S donors to further elucidate the impact of reactive sulfur species in biol. The high modularity of this approach has provided a library of COS-based H2S donors that can be activated by specific stimuli. A common limitation, however, is that many such donors result in the formation of an electrophilic quinone methide byproduct during donor activation. As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS/H2S donor motifs, and that these groups release two equivalent of COS/H2S and uncage an amine payload under physiol. relevant conditions. Addnl., we demonstrate that COS/H2S release from this donor motif can be altered by electronic modulation and alkyl substitution. These insights are further supported by DFT investigations, which reveal that aryl and alkyl thiocarbamates release COS with significantly different activation energies.

Chemistry – A European Journal published new progress about Free energy of activation. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shim, Jae Ho; Nam, Si Hun; Kim, Byeong-Seon; Ha, Deok-Chan published the artcile< Organocatalytic asymmetric Michael addition of ketones to α, β-unsaturated nitro compounds>, Related Products of 19241-24-8, the main research area is ketone unsaturated nitro compound organocatalytic asym Michael addition.

An organic catalyst “”(R, R)-1,2-diphenylethylenediamine(DPEN) derivative”” was developed as a chiral bifunctional organocatalyst and applied for asym. Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-substituted thiourea catalyst in neutral condition provides high chem. yield and enantioselectivities (ee) (up to 96% yield, 98% ee).

Catalysts published new progress about Michael reaction catalysts, stereoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Related Products of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics