Category: 19241-24-8

Aziz, Marian N.; Patel, Arzoo; Iskander, Amany; Chini, Avisankar; Gout, Delphine; Mandal, Subhrangsu S.; Lovely, Carl J. published the artcile< One-Pot Synthesis of Novel 2-Imino-5-Arylidene-Thiazolidine Analogs and Evaluation of Their Anti-Proliferative Activity against MCF7 Breast Cancer Cell Line>, Related Products of 19241-24-8, the main research area is iminoarylidine thiazolidine analog human breast cancer cell antiproliferative activity; X-ray; cytotoxicity; hydrothiolation; propargyl amine; surface-mediated cyclization.

An efficient surface-mediated synthetic method to facilitate access to a novel class of thiazolidines is described. The rationale behind the design of the targeted thiazolidines was to prepare stable thiazolidine analogs and evaluate their anti-proliferative activity against a breast cancer cell line (MCF7). Most of the synthesized analogs exhibited increased potency ranging from 2-15-fold higher compared to the standard reference, cisplatin. The most active thiazolidines contain a halogenated or electron withdrawing group attached to the N-Ph ring of exocyclic 2-imino group. However, combination of the two substituents did not enhance the activity. The anti-proliferative activity was measured in terms of IC50 values using an MTT assay.

Molecules published new progress about Antiproliferative agents. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Related Products of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Lei; Gan, LinLing; Hu, Xiangnan; Li, Wei; Zhu, Dali; Zheng, Jiecheng; Wu, Yue; Yu, Yu; Gan, Zongjie published the artcile< Cu(OAc)2 Mediated mild synthesis of 2-aminobenzimidazoles and 2-aminobenzoxazoles>, HPLC of Formula: 19241-24-8, the main research area is aminobenzimidazole preparation; phenylenediamine isothiocyanate desulfurization copper acetate desulfurization agent; aminobenzoxazole preparation; aminophenol isothiocyanate desulfurization copper acetate desulfurization agent.

An efficient and facile synthesis for 2-aminobenzimidazoles I [R1 = H, 6-Me, 6-OMe, etc.; R2 = C6H5, 2-MeC6H4, 2-ClC6H4, etc.] and 2-aminobenzoxazoles II [R1 = H, Me, Cl; R2 = C6H5, 4-ClC6H4] was reported. Thioureas prepared from the reaction of o-phenylenediamines or 2-aminophenols and isothiocyanate derivatives, underwent desulfurization reaction smoothly under mild conditions in the presence of Cu(OAc)2 and afforded a variety of N-heterocyclic compounds in moderate to good yields.

Synthetic Communications published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, HPLC of Formula: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Rahul; Joshi, Abhisek; Rawat, Deepa; Adimurthy, Subbarayappa published the artcile< Synthesis of thiazolidinimines/thiazinan-2-imines via three-component coupling of amines, vic-dihalides and isothiocyanates under metal-free conditions>, Category: esters-buliding-blocks, the main research area is amine vicinal dihalide isothiocyanate tandem regioselective three component coupling; thiazolidinimine preparation; thiazinanimine preparation.

An expeditious approach for the synthesis of thiazolidin-2-imines and 1,3-thiazinan-2-imines through three-components coupling (TCC) of amines, isothiocynates and dihalides under metal-free conditions was described. Dichloroethane (DCE) employed as two carbon (C2) source for the annulation and obtained saturated five membered heterocycles. With 1,3-dibromopropane, six membered heterocycles were obtained in good yields. The metal-free, broad substrate scope, functional group tolerance and applicability at gram scale synthesis were the advantages of the present protocol.

Synthetic Communications published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Rahul; Ginoya, Vaibhavkumar; Semwal, Rashmi; Adimurthy, Subbarayappa published the artcile< BF3·Et2O catalyzed transannulation of pyridotriazoles with isothiocyanates: synthesis of thiazolo[3,4-a]pyridin-3-imines>, Category: esters-buliding-blocks, the main research area is pyridotriazole isothiocyanat boron trifluoride diethyl etherate catalyst diastereoselective transannulation; thiazolopyridinimine preparation.

The synthesis of thiazolo[3,4-a]pyridin-3-imines through the denitrogenative transannulation of pyridotriazoles with isothiocyanates using BF3·Et2O as a catalyst was described. A combination of solvents (dichlorobenzene-dichloroethane) played a crucial role in obtaining the desired products under transition metal-free conditions.

New Journal of Chemistry published new progress about Cyclization catalysts, stereoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Guangkai; Wang, Bing-Feng; Yang, Shuai; Zhang, Zhi-Xiang; Xu, Han-Hong; Tang, Ri-Yuan published the artcile< DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C-H sulfurization: a new route to 2-aminobenzothiazoles>, SDS of cas: 19241-24-8, the main research area is aryl isothiocyanate DMSO palladium bromide heterocyclization sulfurization tandem reaction; arylaminobenzothiazole preparation.

DMSO was found to activate arylisothiocyanates for self-nucleophilic addition A subsequent intramol. C-H sulfurization catalyzed by PdBr2 enable accessed to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C-H sulfurization of two isothiocyanates.

RSC Advances published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Siddiqui, Hina; Shafi, Sarah; Ali, Hamad; Musharraf, Syed Ghulam published the artcile< Synthesis and Erythroid Induction Activity of New Thiourea Derivatives>, Name: 4-tert-Butylphenylisothiocyanate, the main research area is thiourea fetal Hb erythroid; HbF induction effect; Thiourea derivatives; cytotoxicity; erythroid induction activity; sickle-cell anemia and β-thalassemia; β-thalassemia.

The erythroid induction potential of newly synthesized thiourea derivatives Thiourea derivatives 1-27 were synthesized by using environmentally friendly methods and new compounds 3, 10 and 22 The structures of synthesized derivatives were deduced by using various spectroscopic techniques. These derivatives were then evaluated for their erythroid induction using the human erythroleukemic K562 cell line, as a model. The benzidine-H2O2 assay was used to evaluate erythroid induction, while HbF expression was studied through immunocytochem. using the Anti-HbF antibody. Cytotoxicity of compounds 1-27 was also evaluated on mouse fibroblast 3T3 cell line and cancer Hela cell line using MTT assay. All the compounds (1-27) have not been reported for their erythroid induction activity previously. Compounds 1, 2, and 3 were found to be the potent erythroid inducing agents with % induction of 45± 6.9, 44± 5.9, and 41± 6.1, at 1.56, 0.78, and 0.78 μM concentrations, resp., as compared to untreated control (12 ± 1 % induction). Furthermore, compound 1, 2, and 3 significantly induced fetal Hb the expression up to 4.2-fold, 4.06-fold, and 3.52-fold, resp., as compared to untreated control. Moreover, the compounds 1-4, 6-9, 11, 12, 15, 17, 19, 22, 23, and 25 were found to be non-cytotoxic against the 3T3 cell line. This study signifies that the compounds reported here may serve as the starting point for the designing and development of new fetal Hb inducers for the treatment of beta-hemoglobinopathies.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Cytotoxicity. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Name: 4-tert-Butylphenylisothiocyanate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cerda, Matthew M.; Mancuso, Jenna L.; Mullen, Emma J.; Hendon, Christopher H.; Pluth, Michael D. published the artcile< Use of Dithiasuccinoyl-Caged Amines Enables COS/H2S Release Lacking Electrophilic Byproducts>, SDS of cas: 19241-24-8, the main research area is dithiasuccinoyl carbonyl sulfide hydrogen sulfide release; bioorganic chemistry; carbonyl sulfide; hydrogen sulfide; reactive sulfur species.

The enzymic conversion of carbonyl sulfide (COS) to hydrogen sulfide (H2S) by carbonic anhydrase has been used to develop self-immolating thiocarbamates as COS-based H2S donors to further elucidate the impact of reactive sulfur species in biol. The high modularity of this approach has provided a library of COS-based H2S donors that can be activated by specific stimuli. A common limitation, however, is that many such donors result in the formation of an electrophilic quinone methide byproduct during donor activation. As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS/H2S donor motifs, and that these groups release two equivalent of COS/H2S and uncage an amine payload under physiol. relevant conditions. Addnl., we demonstrate that COS/H2S release from this donor motif can be altered by electronic modulation and alkyl substitution. These insights are further supported by DFT investigations, which reveal that aryl and alkyl thiocarbamates release COS with significantly different activation energies.

Chemistry – A European Journal published new progress about Free energy of activation. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shim, Jae Ho; Nam, Si Hun; Kim, Byeong-Seon; Ha, Deok-Chan published the artcile< Organocatalytic asymmetric Michael addition of ketones to α, β-unsaturated nitro compounds>, Related Products of 19241-24-8, the main research area is ketone unsaturated nitro compound organocatalytic asym Michael addition.

An organic catalyst “”(R, R)-1,2-diphenylethylenediamine(DPEN) derivative”” was developed as a chiral bifunctional organocatalyst and applied for asym. Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-substituted thiourea catalyst in neutral condition provides high chem. yield and enantioselectivities (ee) (up to 96% yield, 98% ee).

Catalysts published new progress about Michael reaction catalysts, stereoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Related Products of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shim, Jae Ho; Nam, Si Hun; Kim, Byeong-Seon; Ha, Deok-Chan published the artcile< Organocatalytic asymmetric Michael addition of ketones to α, β-unsaturated nitro compounds>, Related Products of 19241-24-8, the main research area is ketone unsaturated nitro compound organocatalytic asym Michael addition.

An organic catalyst “”(R, R)-1,2-diphenylethylenediamine(DPEN) derivative”” was developed as a chiral bifunctional organocatalyst and applied for asym. Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-substituted thiourea catalyst in neutral condition provides high chem. yield and enantioselectivities (ee) (up to 96% yield, 98% ee).

Catalysts published new progress about Michael reaction catalysts, stereoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Related Products of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cerda, Matthew M.; Mancuso, Jenna L.; Mullen, Emma J.; Hendon, Christopher H.; Pluth, Michael D. published the artcile< Use of Dithiasuccinoyl-Caged Amines Enables COS/H2S Release Lacking Electrophilic Byproducts>, SDS of cas: 19241-24-8, the main research area is dithiasuccinoyl carbonyl sulfide hydrogen sulfide release; bioorganic chemistry; carbonyl sulfide; hydrogen sulfide; reactive sulfur species.

The enzymic conversion of carbonyl sulfide (COS) to hydrogen sulfide (H2S) by carbonic anhydrase has been used to develop self-immolating thiocarbamates as COS-based H2S donors to further elucidate the impact of reactive sulfur species in biol. The high modularity of this approach has provided a library of COS-based H2S donors that can be activated by specific stimuli. A common limitation, however, is that many such donors result in the formation of an electrophilic quinone methide byproduct during donor activation. As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS/H2S donor motifs, and that these groups release two equivalent of COS/H2S and uncage an amine payload under physiol. relevant conditions. Addnl., we demonstrate that COS/H2S release from this donor motif can be altered by electronic modulation and alkyl substitution. These insights are further supported by DFT investigations, which reveal that aryl and alkyl thiocarbamates release COS with significantly different activation energies.

Chemistry – A European Journal published new progress about Free energy of activation. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics