Category: 19241-24-8

Nielsen, Christian D.-T.; Zivkovic, Filip G.; Schoenebeck, Franziska published the artcile< Synthesis of N-CF3 Alkynamides and Derivatives Enabled by Ni-Catalyzed Alkynylation of N-CF3 Carbamoyl Fluorides>, SDS of cas: 19241-24-8, the main research area is trimethylsilylacetylene trifluoromethyl carbamoyl fluoride nickel catalyst chemoselective alkynylation; trifluoromethyl propiolamide preparation.

The first synthetic access to N-trifluoromethyl alkynamides was reported. Our strategy relies on a mild and operationally simple Ni-catalyzed coupling of N-CF3 carbamoyl fluorides with alkynyl silanes. The synthesized N-CF3 alkynamides proved to be highly robust and readily functioned as a platform to unlock access to valuable derivatives, such as N-CF3 decorated alkenyl amides, oxindoles, or quinolones, all of which were inaccessible to date.

Journal of the American Chemical Society published new progress about Alkylation, chemoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nielsen, Christian D.-T.; Zivkovic, Filip G.; Schoenebeck, Franziska published the artcile< Synthesis of N-CF3 Alkynamides and Derivatives Enabled by Ni-Catalyzed Alkynylation of N-CF3 Carbamoyl Fluorides>, SDS of cas: 19241-24-8, the main research area is trimethylsilylacetylene trifluoromethyl carbamoyl fluoride nickel catalyst chemoselective alkynylation; trifluoromethyl propiolamide preparation.

The first synthetic access to N-trifluoromethyl alkynamides was reported. Our strategy relies on a mild and operationally simple Ni-catalyzed coupling of N-CF3 carbamoyl fluorides with alkynyl silanes. The synthesized N-CF3 alkynamides proved to be highly robust and readily functioned as a platform to unlock access to valuable derivatives, such as N-CF3 decorated alkenyl amides, oxindoles, or quinolones, all of which were inaccessible to date.

Journal of the American Chemical Society published new progress about Alkylation, chemoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bouayad-Gervais, Samir; Nielsen, Christian D.-T.; Turksoy, Abdurrahman; Sperger, Theresa; Deckers, Kristina; Schoenebeck, Franziska published the artcile< Access to Cyclic N-Trifluoromethyl Ureas through Photocatalytic Activation of Carbamoyl Azides>, Name: 4-tert-Butylphenylisothiocyanate, the main research area is cyclic trifluoromethyl urea preparation; carbamoyl azide potocatalytic activation.

Mild activation of carbamoyl azides to the corresponding nitrenes using a blue light/[Ir]-catalyzed strategy, which enabled stereospecific access to N-trifluoromethyl imidazolidinones and benzimidazolones was reported. These novel structural motifs proved to be highly robust, allowing their downstream diversification. On the basis of combined computational and exptl. studies, it was proposed that an electron rebound with the excited metal catalyst was undergone, involving a reduction-triggered nitrogen loss, followed by oxidation to the corresponding carbamoyl nitrene and subsequent C-H functionalization.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Name: 4-tert-Butylphenylisothiocyanate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Tu; Xu, Pengfei; Xu, Xin published the artcile< Scandium complexes containing β-diketiminato ligands with pendant phosphanyl groups: competition between Sc/γ-C [4 + 2] cycloaddition and Sc/P frustrated Lewis pair reactions>, Formula: C11H13NS, the main research area is scandium diketiminato pendant phosphine cycloaddition frustrated Lewis pair reactivity; crystal structure scandium diketiminate phosphine chelate enolate preparation; polymerization catalyst frustrated Lewis pair scandium phosphino diketiminate.

Three cationic Sc aryloxide complexes, i.e., [LScOAr]+[B(C6F5)4]- (Ar = 2,6-tBu2C6H3; L = CH3C(2,6-iPr2C6H3N)C(R)CMe(N(CH2)nCH2PPh2); 6a: n = 1, R = H; 6b: n = 1, R = CH3; 6c: n = 2, R = C6H5CH2), were prepared by a three-step synthetic route. The reactivities of tridentate NNP ligand supported Sc complexes 6 toward various unsaturated substrates were studied. Treatment of 6a with nonconjugated small mols. such as Ph isocyanates, Ph isothiocyanate, and benzaldehyde gave Sc/γ-C [4 + 2] cycloaddition products because of nucleophilic reactivity at the β-diketiminato γ-C, with retention of Sc···P interactions. Analogous Sc/γ-C [4 + 2] cycloaddition reactions occurred for complex 6b with Ph isocyanate and Ph isothiocyanate. Complex 6c, with a bulky benzyl substituent at the γ position of the β-diketiminato ligand, showed typical Sc/P frustrated Lewis pair (FLP) reactivity toward Ph isocyanate to give a 1,2-addition product. Complex 6c was efficient in the polymerization of γ-methyl-α-methylene-γ-butyrolactone (MMBL). The corresponding initiating species, which was formed by Sc/P FLP-type 1,4-addition, was isolated.

Dalton Transactions published new progress about Crystal structure. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Formula: C11H13NS.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Zan; Cao, Ting; Liu, Si; Li, An; Liu, Kun; Yang, Tao; Zhou, Congshan published the artcile< Transition-metal-free S-N bond formation: synthesis of 5-amino-1,2,4-thiadiazoles from isothiocyanates and amidines>, Application In Synthesis of 19241-24-8, the main research area is thiadiazole amino preparation regioselective green chem; amidine isothiocyanate tandem radical oxidative cyclization.

A novel and green method for the synthesis of 5-amino-1,2,4-thiadiazoles I (R1 = Me, cyclopropyl, 4-fluorophenyl, pyridin-3-yl, 1H-pyrazol-1-yl, etc.; R2 = tert-Bu, benzyl, naphth-1-yl, etc.) has been developed by the reaction of isothiocyanates R2N=C=S with amidines R1C(=NH)NH2.HCl. This protocol which is free of metal, catalyst and iodine involves O2 oxidative S-N bond formation for the synthesis of various 5-amino-1,2,4-thiadiazole derivatives I with excellent to good yields. High regioselectivity, mild reaction conditions, broad substrate scope and good functional group tolerance are the highlights of the report.

New Journal of Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pan, Bo-Wen; Shi, Yang; Li, Wen-Chao; Wang, Qing; Pan, Meng; Wu, Qiong; Fu, Hong-Zheng published the artcile< Synthesis and biological evaluation of Vinpocetine derivatives>, Application In Synthesis of 19241-24-8, the main research area is vinpocetine derivative preparation PDE1A inhibitor vasorelaxant; PDE1A; Structural modification; Vinpocetine.

A new series of Vinpocetine derivatives were synthesized and evaluated for their inhibitory activity on PDE1A in vitro. Seven compounds with higher inhibitory activity were selected for surface plasmon resonance (SPR) binding experiments Compared with Vinpocetine, these high potency compounds presented a higher binding affinity with PDE1A, which was consistent with inhibitory activity. After further screening, four compounds and Vinpocetine were selected to examine the vasorelaxant effects on endothelium-intact rat thoracic aortic rings. The study suggested that the effects of compounds I (R1 = 4-fluorophenyl) and I (R1 = 3-fluorophenyl) were the most significant with the maximum value of 93.46 ± 0.77% and 92.90 ± 0.78% (n = 5) at a concentration of 100μM resp. Based on these studies, compounds I (R1 = 4-fluorophenyl) and I (R1 = 3-fluorophenyl) were considered for further development as hit compounds

Bioorganic & Medicinal Chemistry Letters published new progress about Cerebrovascular disease. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bouayad-Gervais, Samir; Scattolin, Thomas; Schoenebeck, Franziska published the artcile< N-Trifluoromethyl Hydrazines, Indoles and Their Derivatives>, Recommanded Product: 4-tert-Butylphenylisothiocyanate, the main research area is trifluoromethyl hydrazine indole derivative preparation; N-CF3 hydrazine; N-CF3 indole; fluorine; synthesis.

Reported herein is the first efficient strategy to synthesize a broad range of unsym. N-CF3 hydrazines, which served as platform to unlock numerous currently inaccessible derivatives, such as tri- and tetra-substituted N-CF3 hydrazines, hydrazones, sulfonyl hydrazines, and valuable N-CF3 indoles. These compounds proved to be remarkably robust, being compatible with acids, bases, and a wide range of synthetic manipulations. The feasibility of RN(CF3)-NH2 to function as a directing group in C-H functionalization is also showcased.

Angewandte Chemie, International Edition published new progress about Acid fluorides Role: RCT (Reactant), RACT (Reactant or Reagent) (carbamoyl). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Recommanded Product: 4-tert-Butylphenylisothiocyanate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gan, Ziyu; Li, Guoqing; Yan, Qiuli; Deng, Weiseng; Jiang, Yuan-Ye; Yang, Daoshan published the artcile< Visible-light-promoted oxidative desulphurisation: a strategy for the preparation of unsymmetrical ureas from isothiocyanates and amines using molecular oxygen>, Computed Properties of 19241-24-8, the main research area is unsym urea preparation photochem green chem; isothiocyanate amine oxidative desulfurization photoredox catalyst.

A green and efficient visible-light promoted oxidative desulfurization protocol has been proposed for the construction of unsym. ureas R1NHC(O)N(R2)R3 [R1 = Ph, propan-2-yl, 4-chlorophenyl, etc.; R2 = H, Et, n-Pr, n-Bu, Bn, cyclohexyl; R3 = n-Bu, Bn, 2-(thiophen-2-yl)ethyl, etc.; R2R3 = -(CH2)5-, -(CH2)2O(CH2)2-] and I under mild conditions with broad substrate scope and good functional group tolerance. Most appealingly, the reaction can proceed smoothly without adding any strong oxidants. Control experiments and computational studies support a mechanism involving water-assisted in situ generation of thioureas and photocatalytic oxidative desulfurization. The present method provides a promising synthesis strategy for the formation of diverse and useful unsym. urea derivatives I in the fields of pharmaceutical and synthetic chem.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Computed Properties of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Huawen; Qu, Zhonghua; Ji, Xiaochen; Deng, Guo-Jun published the artcile< Three-component bis-heterocyclization for synthesis of 2-aminobenzo[4,5]thieno[3,2-d]thiazoles>, HPLC of Formula: 19241-24-8, the main research area is amino benzothieno thiazole preparation regioselective; methylketoxime acetate isothiocyanate three component heterocyclization.

A cooperative base system has been developed for the novel three component bis-heterocyclization of methylketoxime acetates. The present protocol provides an effective entry to 2-aminobenzo[4,5]thieno[3,2-d]thiazoles, e.g., I. Mechanistically, the formation of trisulfur radical anion [S3] ̇- and Willgerodt-Kindler-type sulfuration would be the key for this transformation.

Organic Chemistry Frontiers published new progress about Fused heterocyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, HPLC of Formula: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh, Ravi P.; Aziz, Marian N.; Gout, Delphine; Fayad, Walid; El-Manawaty, May A.; Lovely, Carl J. published the artcile< Novel thiazolidines: Synthesis, antiproliferative properties and 2D-QSAR studies>, Name: 4-tert-Butylphenylisothiocyanate, the main research area is imino methoxybenzylidene thiazolidine thiazolidinone preparation antiproliferative human QSAR; 2D-QSAR; HCT-116; One-pot; Tandem reaction.

A series of N-substituted (Z)-2-imino-(5Z)-ylidene thiazolidines and (Z)-2-imino-(5Z)-ylidene thiazolidin-4-ones were synthesized and their antiproliferative activities against colon (HCT-116) and breast (MCF7) cancer cell lines were evaluated utilizing an MTT growth assay. A 2D-QSAR investigation was conducted to probe and validate the obtained antiproliferative properties for the thiazolidine derivatives The majority of the thiazolidines exhibit higher potency against a colon cancer cell line relative to the standard reference The p-halophenylimino p-anisylidene derivatives exhibited the highest anti-proliferative activity against HCT116 relative to control (IC50 = 8.9-10.0μM compared to 20.4μM observed for 5-fluorouracil as pos. control). An X-ray study confirmed the Z,Z’-configurations for two examples of the synthesized compounds

Bioorganic & Medicinal Chemistry published new progress about Amines, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Name: 4-tert-Butylphenylisothiocyanate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics