Category: 19064-14-3

Adding a certain compound to certain chemical reactions, such as: 19064-14-3, name is Ethyl 2,6-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19064-14-3, SDS of cas: 19064-14-3

A. Ethyl-2-fluoro-6[(3,4-methylenedioxy)phenoxy]benzene-carboxylate Sesamol (3,4-methylenedioxyphenol; 423 mg, 3.0 mmol) was added as a solution in THF (1.0 ml) to a suspension of mineral oil free-sodium hydride (72 mg, 3.0 mmol) in THF (0.5 ml) under water cooling. The mixture was stirred at 25 C. for 20 minutes. The solvent was evaporated at 40 C. under reduced pressure. A solution of ethyl-2,6-difluorobenzene-carboxylate (EXAMPLE 1C; 373 mg, 2.0 mmol) in DMSO (0.5 ml) was added to a solution of the solid prepared above in DMSO (1.0 ml). The brownish solution was heated at 80 C. for 2 hours. The solvent was evaporated, the solid filtered, washed with water several times and dried. The crude product was purified by flash column chromatography on silica gel using 3-15% ethyl acetate in hexane to give 371 mg of the product (61% yield) as a light yellow oil and unreacted sesamol.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2,6-difluorobenzoate, and friends who are interested can also refer to it.

Reference:
Patent; Texas Biotechnology Corporation; US5977117; (1999); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

19064-14-3, name is Ethyl 2,6-difluorobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 19064-14-3

D. Ethyl 2-fluoro-6-[3,4-(methylene)dioxyphenoxy]benzoate Ethyl 2,6-difluorobenzoate (558 mg, 3.0 mmol) was added to dry sodium 3,4-methylenedioxyphenoxide (3.0 mmol, prepared as described in part A) in DMSO followed by addition of dry DMSO (2 ml). The reaction mixture was warmed to 50 C. forming a solution which turned from brown to green upon further heating. After 90 min., the reaction was cooled to 25 C., diluted with water (10 ml) and extracted with EtOAc (3*10 ml). The organic extract was washed with water (2*7 ml) and brine (7 ml), dried (MgSO4) and concentrated to give a light yellow oil. The product was purified by flash chromatography on SiO2 (5-20% EtOAc/hexane) yielding 532 mg of ethyl 2-fluoro-6-[3,4-(methylenedioxy)phenoxy]benzoate as a colorless oil (58% yield).

The synthetic route of 19064-14-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Texas Biotechnology Corporation; US5977117; (1999); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 19064-14-3, A common heterocyclic compound, 19064-14-3, name is Ethyl 2,6-difluorobenzoate, molecular formula is C9H8F2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2: 1.5M t-BuLi in pentane (193 mL, 289 mmol) was added to a solution of the intermediate of step 1 (20.0 g, 96.1 mmol) and TMEDA (43.5 mL, 289 mmol) in dry THF (600 mL) at -70X under inert atmosphere and the RM was stirred for 1 h at -50C. A solution of ethyl 2,6-difluorobenzoate (21.5 g, 115 mmol) in dry THF (200 mL) was added at -70C and the RM was stirred for 1 h at -70C, 1 h at 0C and 2 h at rt. The RM was quenched with 5.5M HCI (600 mL) and heated at 70C for 5 h. The mixture was cooled to rt, neutralized through the addition of NaHC03 and extracted with EtOAc. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified by CC (silica gel, CH2CI2/MeOH) to yield the desired compound (5.5 g, 25%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GRUeNENTHAL GMBH; VOSS, Felix; RITTER, Stefanie; NORDHOFF, Sonja; WACHTEN, Sebastian; OBERBOeRSCH, Stefan; KLESS, Achim; WO2015/22073; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics