Category: 19063-56-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19063-56-0, name is 7-Bromo-2H-chromen-2-one, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H5BrO2

N-butyl-1,8-naphthalimide borate 11 (0.2 g, 0.53 mmol), 7-bromocoumarin(0.12 g, 0.53 mmol), Pd(PPh3)4 (0.024 g, 4 mol%) and 2Msodium carbonate solution (4 mL) were dissolved in THF (20 mL). Thereaction mixture was left for 8 h under nitrogen atmosphere at 70 C.After completion of the reaction, the reaction mixture was cooled toroom temperature and poured into water (50 mL), then extracted withdichloromethane (50 mLx 2). The organic layer was separated, washedwith saturated brine solution, dried over Na2SO4 and concentrated invacuum. The resulting residue was purified by column chromatographyon silica gel with hexane: ethyl acetate (8:2, v/v) as eluant. NC 4 wasobtained in 52.5% yield (0.11 g), m. p. 222 C. IR (KBr): numax/cm-11729 (nuCO), 1691 (nuCO). 1H NMR (400 MHz, CDCl3) delta 8.687-8.658 (m,2H, aromatic), 8.218 (d, 1H, J=8.8 Hz, aromatic), 7.836 (d, 1H,J=9.6 Hz, aromatic), 7.766-7.672 (m, 3H, aromatic), 7.503 (s, 1H,aromatic), 7.447 (d, J=8 Hz, 1H, aromatic), 6.546 (d, 1H, J=9.6 Hz),4.224 (t, 2H, J=7.6 Hz, CH2), 1.788-1.712 (m, 2H, CH2), 1.521-1.446(m, 2H, CH2), 0.996 (t, 3H, J=7.6 Hz, CH3)·13C (150 MHz, CDCl3) delta164.11, 163.88, 160.36, 154.01, 144.40, 142.87, 142.59, 131.77,131.41, 130.64, 129.63, 128.64, 128.10, 127.92, 127.35, 126.08,123.10, 122.66, 118.73, 118.20, 117.45, 40.34, 30.17, 20.37, 13.84.HRMS (m/z): [M+H] calculated for C25H20NO4: 398.1392; Found:398.1384

The synthetic route of 19063-56-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Reddy, T. Sheshashena; Hwang, Jiyoung; Choi, Myung?Seok; Dyes and Pigments; vol. 158; (2018); p. 412 – 419;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

19063-56-0, name is 7-Bromo-2H-chromen-2-one, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 7-Bromo-2H-chromen-2-one

General procedure: A 10 mL vial equipped with a small magnetic stirring bar wascharged with the appropriate bromo O-hetarene (1.0 equiv, 100mg), Pd(OAc)2 (5 mol%), and CuI (1.0 equiv). Anhyd DMF (1 mL)and the appropriate 1,3-azole (2.0 equiv) were added, and thevessel was purged with N2 and sealed with a PEEK snap cap. Themixture was stirred for 5 min at r.t. before the vessel was placedin the microwave reactor and the mixture was heated to 140 Cwith stirring for the appropriate time (usually 1 h). The solutionwas then cooled to r.t., diluted with EtOAc (15 mL), washed withsat. aq NH4Cl (2 × 15 mL) and dilute aq Na2S2O3 (10 mL). Theaqueous phases were extracted with EtOAc (2 × 10 mL), and theorganic phases were combined and washed with sat. aq NH4Cl(10 mL) and brine. Some H2O was added if any solids precipitatedduring the extraction. The combined organic phases weredried (MgSO4), filtered, and concentrated. The residue was purifiedby column chromatography (silica gel).

The synthetic route of 19063-56-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sipos, Zoltan; Konya, Krisztina; Synlett; vol. 29; 18; (2018); p. 2412 – 2416;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19063-56-0, name is 7-Bromo-2H-chromen-2-one belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C9H5BrO2

2-Butyl-6-ethynyl-1H-benz [de]isoquinoline-1,3(2H)-dione 14(0.2 g, 0.722 mmol) and 7-Bromocoumarin (0.16 g, 0.722 mmol) weredissolved in THF-triethylamine (1:1, v/v, 120 mL) and the mixture wasdeaerated for 10 min by bubbling nitrogen gas. Then, Pd(PPh3)2Cl2(10.35 mg, 2 mol%), PPh3 (7.5 mg, 4 mol%) and CuI (2.75 mg, 2mol%)were added. The solution was deaerated for further 5 min; after that,the reaction was left for 8 h under nitrogen atmosphere at 60 C. Aftercompletion of the reaction, the reaction mixture was cooled to roomtemperature and the solvent was evaporated. The crude product wasdissolved in dichloromethane and purified by silica gel column chromatographywith chloroform as eluant. NC 5 was obtained in 60.2%yield (0.18 g), m. p. 252 C. IR (KBr): numax/cm-1 2200 (nuC?C) 1740(nuCO), 1693 (nuCO). 1H NMR (400 MHz, CDCl3) delta8.712 (d, 1H,J=8.40 Hz, aromatic),8.675 (d, 1H, J=7.2 Hz, aromatic),8.59 (d, 1H,J=7.6 Hz, aromatic),8.01 (d, 1H, J=7.60 Hz, aromatic), 7.882 (t, 1H,J=8 Hz, aromatic), 7.74 (d, 1H, J=9.2 Hz, aromatic), 7.62 (s, 1H),7.56-7.55 (m, 2H, aromatic), 6.49 (d, 1H, J=9.6 Hz, aromatic), 4.19(t, 2H, J=7.6 Hz, CH2), 1.77-1.69 (m, 2H, CH2), 1.49-1.41 (m, 2H,CH2), 0.99 (t, 3H, J=7.6 Hz, CH3). 13C (150 MHz, CDCl3) delta163.86,163.61, 160.08, 153.84, 142.59, 132.0, 131.72, 131.55, 131.26,130.23, 128.06, 128.01, 127.81, 127.74, 126.38, 125.70, 123.10,122.82, 119.87, 119.53, 117.60, 96.96, 89.34, 40.38, 30.19, 20.38,13.85. HRMS (m/z): [M+H] calculated for C27H20NO4:422.1392;Found: 422.1399.

The synthetic route of 19063-56-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Reddy, T. Sheshashena; Hwang, Jiyoung; Choi, Myung?Seok; Dyes and Pigments; vol. 158; (2018); p. 412 – 419;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 19063-56-0, The chemical industry reduces the impact on the environment during synthesis 19063-56-0, name is 7-Bromo-2H-chromen-2-one, I believe this compound will play a more active role in future production and life.

General procedure: A 10 mL vial equipped with a small magnetic stirring bar wascharged with the appropriate bromo O-hetarene (1.0 equiv, 100mg), Pd(OAc)2 (5 mol%), and CuI (1.0 equiv). Anhyd DMF (1 mL)and the appropriate 1,3-azole (2.0 equiv) were added, and thevessel was purged with N2 and sealed with a PEEK snap cap. Themixture was stirred for 5 min at r.t. before the vessel was placedin the microwave reactor and the mixture was heated to 140 Cwith stirring for the appropriate time (usually 1 h). The solutionwas then cooled to r.t., diluted with EtOAc (15 mL), washed withsat. aq NH4Cl (2 × 15 mL) and dilute aq Na2S2O3 (10 mL). Theaqueous phases were extracted with EtOAc (2 × 10 mL), and theorganic phases were combined and washed with sat. aq NH4Cl(10 mL) and brine. Some H2O was added if any solids precipitatedduring the extraction. The combined organic phases weredried (MgSO4), filtered, and concentrated. The residue was purifiedby column chromatography (silica gel).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-2H-chromen-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sipos, Zoltan; Konya, Krisztina; Synlett; vol. 29; 18; (2018); p. 2412 – 2416;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 19063-56-0, The chemical industry reduces the impact on the environment during synthesis 19063-56-0, name is 7-Bromo-2H-chromen-2-one, I believe this compound will play a more active role in future production and life.

General procedure: A 10 mL vial equipped with a small magnetic stirring bar wascharged with the appropriate bromo O-hetarene (1.0 equiv, 100mg), Pd(OAc)2 (5 mol%), and CuI (1.0 equiv). Anhyd DMF (1 mL)and the appropriate 1,3-azole (2.0 equiv) were added, and thevessel was purged with N2 and sealed with a PEEK snap cap. Themixture was stirred for 5 min at r.t. before the vessel was placedin the microwave reactor and the mixture was heated to 140 Cwith stirring for the appropriate time (usually 1 h). The solutionwas then cooled to r.t., diluted with EtOAc (15 mL), washed withsat. aq NH4Cl (2 × 15 mL) and dilute aq Na2S2O3 (10 mL). Theaqueous phases were extracted with EtOAc (2 × 10 mL), and theorganic phases were combined and washed with sat. aq NH4Cl(10 mL) and brine. Some H2O was added if any solids precipitatedduring the extraction. The combined organic phases weredried (MgSO4), filtered, and concentrated. The residue was purifiedby column chromatography (silica gel).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-2H-chromen-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sipos, Zoltan; Konya, Krisztina; Synlett; vol. 29; 18; (2018); p. 2412 – 2416;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics