Category: 18927-05-4

Application of 18927-05-4, These common heterocyclic compound, 18927-05-4, name is Methyl 3-Methoxyphenylacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 1.4mmol of 5-amino-1-substituted-4-carboxamide-1H-imidazole (1) was dissolved in 10mL of absolute methanol. Then 5.6mmol of the appropriate ester isadded into this solution. This mixture was added in 10mL ofmethoxide-methanol solution prepared from sodium (0.15 g, 6.3mmol) and 10mL of absolute methanol. The mixture was refluxed for 15-20 h. After cooling, the solvent was evaporated off and the residue was taken into ethyl acetate. The organic phase was dried over Na2SO4 and evaporated. And the residue was purified via silica gel chromatography(eluent: the mixture of ethyl acetate and methanol) to obtainthe pure product (2a-2q).

Statistics shows that Methyl 3-Methoxyphenylacetate is playing an increasingly important role. we look forward to future research findings about 18927-05-4.

Reference:
Article; Yuan, Wei; Zhao, Xin-Yun; Chen, Xi; Zhan, Chang-Guo; Journal of Chemistry; vol. 2016; (2016);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 18927-05-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18927-05-4, name is Methyl 3-Methoxyphenylacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of sodium hydride (13.2 g, 303.6 mmol) in dimethylformamide (350 mL) was added methyl 3-methoxyphenylacetate (25 g, 138 mmol) and methyl acrylate (31 ml, 345 mmol) in dimethylformamide (160 mL) at 0C, then the reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into aqueous hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtrated, and concentrated in vacuo. The residue was purified by silica gel chromatography to give 42.8 g of the title compound as a colorless oil. High-performance liquid chromatography/mass spectrometry m/z 321(M+H) Retention time: 3.61 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-Methoxyphenylacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP1679069; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 18927-05-4,Some common heterocyclic compound, 18927-05-4, name is Methyl 3-Methoxyphenylacetate, molecular formula is C10H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Nitrobenzene (0.4 mmol), methylmethoxyphenylacetate (0.2 mmol),Dimethyl sulfoxide (0.5 mL) and sodium tert-butoxide (0.4 mmol) were successively added to the reaction flask and the reaction was carried out at 45 C for 8 hours. The reaction product was separated from the reaction solution by adding water, dilute hydrochloric acid and ethyl acetate, and the product was isolated by silica gel column chromatography. The yield was 43%, yellow solid,

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-Methoxyphenylacetate, its application will become more common.

Reference:
Patent; Changsha University of Science and Technology; Li Jiangsheng; Yang Fan; Yang Qian; Li Zhiwei; Chen Guoqin; (8 pag.)CN107033006; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

18927-05-4, name is Methyl 3-Methoxyphenylacetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C10H12O3

[0333] AIBN (10 mg) was added to a solution of (3-Methoxy-phenyl)-acetic acid methyl ester (2g, 11MMOL) in [CCl4] (30ml). The solution was then heated to reflux and NBS (2.3g, 13MMOL) was added in portions. After complete addition the reaction mixture was refluxed for 4h. After cooling, solid residue was filtered off and the filtrate concentrated to yield product BROMO-(3-METHOXY-PHENYL)-ACETIC acid methyl ester, that was washed repeatedly with pet ether.

The synthetic route of 18927-05-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2003/105853; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 18927-05-4, name is Methyl 3-Methoxyphenylacetate, molecular formula is C10H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 18927-05-4

Methyl bromo(3-methoxyphenyl)acetate; A mixture of 15.7 g (87.1 mmol) of methyl (3-methoxyphenyl)acetate, 16.3 g (91.5 mmol) of Lambda/-bromosuccinimide and a catalytic amount of AIBN in tetrachloromethane (150 ml) was heated under reflux with stirring for 2 h. The cooled reaction solution was filtered and the solvent was removed in vacuo. Yield: 21.8 g (100%) of yellow oil 1H-NMR (DMSOd6): 3.72 (s, 3H), 3.76 (s, 3H), 5.90 (s, 1 H), 6.92-6.97 (m, 1 H), 7.08- 7.13 (m, 2H), 7.28-7.34 (m, 1 H). MS (API-ES,pos) m/z = 261 [M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 18927-05-4, its application will become more common.

Reference:
Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

18927-05-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18927-05-4, name is Methyl 3-Methoxyphenylacetate, This compound has unique chemical properties. The synthetic route is as follows.

To methyl 2-(3-methoxyphenyl)acetate (Aldrich, 1 g, 5.55 mmol) in THF (10 ml) at 00C, NaHMDS (5.55 ml, 5.55 mmol) was added. After stirring at 00C for 10 min, reaction mixture was stirred at RT for 0.5h and then MeI (0.4 ml) was added. After 45 min, another 5.55 ml of NaHMDS was added at 00C. Again after stirring at RT for 0.5 h, 0.5 ml of MeI was added and the reaction mixture was stirred at RT for 2h. Then the reaction mixture was quenched with ammonium chloride and solvent removed. Then the reaction mixture was diluted with ethyl acetate, acidified with 2N HCl and washed with ether. Aqueous layer was then basified and extracted with CHCl3. organic layer was dried and evaporated to yield methyl 2-(3-methoxyphenyl)-2-methylpropanoate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics