Category: 18830-44-9

These common heterocyclic compound, 18830-44-9, name is Methyl 3,3,3-trifluoropropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 18830-44-9

General procedure: R2BCl (2.0 mmol) was added dropwise to the solution of ester (1.0 mmol) and amine (3.0 mmol) in dichloromethane (3.5 mL) at -78 C and stirred at the same temperature for 1.5 h. Aldehyde (1.5 mmol) dissolved in dichloromethane was then added dropwise to the above reaction mixture and stirred at -78 C for 1 h and 0 C for 1 h. The reaction was quenched by the addition of pH 7 buffer solution (2 mL). The mixture was diluted with MeOH (2 mL), followed by the careful addition of 30% hydrogen peroxide (2 mL) and stirred vigorously for 4-5 h. The reaction mixture was partitioned between water (4 mL) and dichloromethane. The aqueous layer was extracted with dichloromethane (3 x 10 mL) and the combined organics were washed with brine (5 mL), dried (anhydrous Na2SO4), filtered, concentrated and purified by silica gel chromatography to obtain the pure aldol product.

The synthetic route of Methyl 3,3,3-trifluoropropanoate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Veeraraghavan Ramachandran; Gagare, Pravin D.; Parthasarathy, Gowrisankar; Tetrahedron Letters; vol. 52; 46; (2011); p. 6055 – 6057;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18830-44-9, name is Methyl 3,3,3-trifluoropropanoate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

28.1. methyl 2-benzyl-4,4,4-trifluoro-3,3-dihydroxybutanoate To a solution of 675 mg (29.4 mmol) of sodium in 15 mL of anhydrous MeOH, under argon, are added dropwise 3.73 mL (29.4 mmol) of methyl 3,3,3-trifluoropropanoate. After stirring for 30 minutes at room temperature, 3.5 mL of benzyl bromide are added and the medium is heated for 12 hours at 70 C. The reaction mixture is then concentrated under reduced pressure. The residue obtained is taken up in 100 mL of EtOAc, washed with 50 mL of brine, dried over Na2SO4, filtered and concentrated under reduced pressure. After purification by chromatography on a column of silica gel, eluting with a cyclohexane/EtOAc mixture (85/15), 3.4 g of methyl 2-benzyl-4,4,4-trifluoro-3,3-dihydroxybutanoate are obtained in the form of an oil, which is used without further purification in the following step. Yield=37%.

The synthetic route of 18830-44-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18830-44-9, name is Methyl 3,3,3-trifluoropropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H5F3O2

Put 67.1g of sodium hydroxide and 300g of deionized water into a 500ml reaction bottle, cool the ice water bath to 5 10 , drop 216.6g of methyl trifluoropropionate above, control the internal temperature below 30 , and continue stirring after the dripping 30min.Concentrated hydrochloric acid was added dropwise to the reaction bottle until the pH of the reaction solution was below 2, and stirring was continued for 30 min after completion of the drop.300 g of dichloromethane was added to the reaction flask for extraction twice, and the dichloromethane was concentrated and recovered to obtain crude trifluoropropionic acid.Set up a vacuum distillation device, vacuum distillate crude trifluoropropionic acid, collect 83 ~ 85 fraction (vacuum degree -0.097MPa), which is 3,3,3-trifluoropropionic acid, weight 199g, purity 99.2%, yield 88.0%, total reaction yield 66.2%.

The synthetic route of 18830-44-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hunan Youse Chenzhoufu Chemical Co., Ltd.; Wang Gang; Peng Zhimin; Li Zhipeng; Yin Demei; Zhang Zhenhua; (8 pag.)CN110903183; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics