Category: 1865-29-8

Synthetic Route of 1865-29-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1865-29-8, name is Methyl 2-phenylacrylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Add Cu (OAc) 2 · H2O (2.0mg) to a dry reaction flask replaced with nitrogen(R) -L4 (Ar ‘= 4-Me-3,5- (t-Bu) 2-Ph) (5.6 mg), toluene (2.0 mL), and stirred at room temperature until a blue solution.Reduce the temperature to -25 , add Poly(methylhydrosiloxane) (120muL) and tert-butanol (182muL) to the above liquid,After stirring for 5 min, methyl 2-phenylacrylate (161 mg) was added.After stirring for 2h, then add saturated NH4Cl solution (4.0mL), continue stirring for 30min, and then separate the liquid,The aqueous phase was extracted with ethyl acetate (3 × 5.0 mL), and the combined organic phase was washed with saturated NaCl solution,The product was dried, concentrated and separated by anhydrous sodium sulfate (149mg, yield 91%, ee 35%,The dominant configuration is (S) -configuration.

The synthetic route of Methyl 2-phenylacrylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dalian University; Li Zhengning; Zhao Xiaoyuan; Bai Rui; Li Quancheng; Jiang Lan; (11 pag.)CN110903189; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

1865-29-8, name is Methyl 2-phenylacrylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Methyl 2-phenylacrylate

0.01 mmol Ru (COD)2X and 0.01 mmol of the ferrocenyl ligand are dissolved in 12 ml of the appropriate solvent in a 25 ml shaker vessel. After the addition of 1 mmol of the unsaturated ester the solution is transferred under argon into a 100 ml steel autoclave and heated after multiple rinsing with H2 for 10 min. at the appropriate hydrogen pressure to reaction temperature. The mixture is then agitated, filtered, (the optionally added acid esterified with Me3SiCHN2) and the enantiomeric excess determined by HPLC [(Chiracel OJ, n-heptane/isopropanol 95:5; flow 0.6 mL/min, T=20 C.; tR=18.05 (S), 21.13 (R)]. alpha-phenylacrylic acid: Solvent: THF Reaction temperature: 60 C. Pressure: 5000 kPa

The synthetic route of 1865-29-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Degussa-Huls AG; US6348620; (2002); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 1865-29-8,Some common heterocyclic compound, 1865-29-8, name is Methyl 2-phenylacrylate, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The title compound was synthesized according to a literature method (Whitman Tetrahedron 1985, 41, 1183). To a mixture of 2-phenylacrylic acid methyl ester (7.92g, 45 mmol) in 60 ml of methylene chloride was added mCPBA (13. Ig, 58.5 mmol) and the reaction was stirred at 450C overnight. The reaction mixture was then filtered and the solid was washed with methylene chloride. The filtrate was washed three times with 50 ml of equal parts solution consisting of saturated Na2S2O3 and saturated NaHCO3. The organic layer was washed with water and brine, dried over MgSO4, and concentrated under reduced pressure to afford the title compound in greater than 95% purity according to 1H NMR (85% yield). 1H NMR (CDCl3, 300MHz) delta: 7.50 -7.30 (m, 5H), 4.22 (q, J= 7.2 Hz, 2H), 3.40 (d, J, = 7.1 Hz, IH), 2.95 (d, J= 7.1Hz, IH), 1.26 (t, J=7.2Hz, 3H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-phenylacrylate, its application will become more common.

Reference:
Patent; YUDIN, Andrei, K.; HILI, Ryan; WO2008/46232; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The chemical industry reduces the impact on the environment during synthesis 1865-29-8, name is Methyl 2-phenylacrylate, I believe this compound will play a more active role in future production and life. 1865-29-8

A solution of LiAlD4 (95 mg, 2.3 mmol) and AlCl3 (100 mg, 0.75 mmol) in THF was allowed to stir for 10 minutes before the addition of ester 16 (120 mg, 0.74 mmol) in THF. After 1.5 hours, the solution was quenched by addition of H2O, extracted with ether, and the ether extracts were dried (MgSO4) and concentrated in vacuo. The resulting oil was purified via flash column chromatography (15% EtOAc in hexane) to give the desired product 19 as a white solid (35 mg, 35%).

The chemical industry reduces the impact on the environment during synthesis 1865-29-8. I believe this compound will play a more active role in future production and life.

Reference:
Article; Richardson, Rebekah M.; Barney, Rocky J.; Wiemer, David F.; Tetrahedron Letters; vol. 53; 49; (2012); p. 6682 – 6684;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 1865-29-8, name is Methyl 2-phenylacrylate, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1865-29-8

PREPARATION 21 Methyl (RS)-4-cyano-2-Phenylbutanoate STR75 Lithium diisopropylamide (3.67 ml of a 1.5 molar solution in cyclohexane) was added to acetonitrile (0.26 ml) in tetrahydrofuran (10 ml) at -78 C. After 1 hour, methyl 2-phenyl-acrylate (see Preparation 22) (0.81 g) in tetrahydrofurn (10 ml) was added and the mixture was stirred for 1 hour, allowed to warm to room temperature then treated with saturated ammonium chloride solution. The resulting mixture was partitioned between ethyl acetate and water, the organic phase dried over magnesium sulphate and evaporated to give a residue which was partitioned between ether and 10% aqueous sodium carbonate. The organic layer was dried over magnesium sulphate and evaporated to leave the title compound (0.5 g, 75%) as an oil. 1 H-NMR (300 MHz, CDCl3), delta=2.0-2.4 (m, 4H), 3.7 (s, 3H), 3.8 (t, 1H), 7.2-7.5 (m, 5H) ppm. I.R. (thin film) 2220 cm-1 (C=N).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1865-29-8, its application will become more common.

Reference:
Patent; Pfizer Inc.; US5292749; (1994); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics