Category: 18595-16-9

Related Products of 18595-16-9, The chemical industry reduces the impact on the environment during synthesis 18595-16-9, name is Methyl 2-amino-5-methylbenzoate, I believe this compound will play a more active role in future production and life.

EXAMPLE 4 Preparation of 2-phenylthio-6-methyl-4H-3,1-benzoxazin-4-one 2-Amino-5-methylbenzoic acid methyl ester (122 mg, 0.79 mmol) and triethylamine (0.28 ml, 1.96 mmol) were dissolved in THF (10 ml). A 20% solution of phosgene in toluene (0.74 ml, 1.6 mmol) was added, causing immediate formation of a white precipitate.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Downham, Robert; Palmer, Richard Michael John; Hodson, Harold Francis; Dunk, Christopher Robert; US2003/176429; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

18595-16-9, Name is Methyl 2-amino-5-methylbenzoate, 18595-16-9, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

Step 1: To a solution of 2-amino-5-methyl benzoic acid (1.0 mmol) dissolved in 10% MeOH in toluene (2.5 mL) is added dropwise trimethylsilyl-diazomethane (2.0 M in hexanes, 0.75 mL). The reaction mixture is stirred at room temperature for 1 hour and the solvent is removed under reduced pressure. The resulting methyl ester is dissolved in dichloromethane (3.0 mL) and then 4-chlorobenzoyl chloride (1.0 equivalent) and DIEA (1.0 equivalent) is added sequentially. The reaction mixture is stirred for 3 hours and the solvent is evaporated. The yellow residue is diluted with EtOAc, washed with 1 M NaHSO4, brine, dried, filtered and concentrated under reduced pressure to provide 2-(4-chloro-benzoylamino)-5-methyl-benzoic acid methyl ester (compound 11.1) which is used without purification in the next step.

Statistics shows that Methyl 2-amino-5-methylbenzoate is playing an increasingly important role. we look forward to future research findings about 18595-16-9.

Reference:
Patent; Lew, Willard; Baskaran, Subramanian; Oslob, Johan D.; Yoburn, Joshua C.; Zhong, Min; US2006/35908; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics