Application of 18595-13-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18595-13-6, name is Methyl 2-amino-6-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 2. Preparation of 2-Isopropoxycarbonylamino-6-methyl-benzoic acid methyl ester. Add isopropyl chloroformate (19.8 mL, 19.8 mmol, 1.0 M in toluene) dropwise to a solution of 2-Amino-6-methyl-benzoic acid methyl ester (3.27 g, 19.8 mmol) and pyridine (4.0 mL, 50 mmol) in dichloromethane (39 mL) at 0C under an atmosphere of nitrogen and stir at room temperature for 14 h. Add 1M HCl and separate the layers. Extract the aqueous layer with dichloromethane. Dry the organic layer over anhydrous sodium sulfate, filter, and remove the solvent under reduced pressure. Purify the residue by flash chromatography, eluting with hexanes/ethyl acetate, to afford the title compound (3.80 g, 76%) :’H NMR (CDCl3) 8 1.29 (d, J = 6.5 Hz, 6H), 2.43 (s, 3H), 3.94 (s, 3H), 5.00 (septuplet, J = 6.5 Hz, 1H), 6.90 (d, J = 8.1 Hz, 1H), 7.32 (t, J = 8.1 Hz, 1H), 8.07 (d, J = 8.1 Hz, 1H), 8.86 (brs, 1H). MS (ES+): 252 (M+H).
The synthetic route of Methyl 2-amino-6-methylbenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/37796; (2005); A1;,
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