Category: 18358-63-9

Related Products of 18358-63-9,Some common heterocyclic compound, 18358-63-9, name is Methyl 4-(methylamino)benzoate, molecular formula is C9H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Part D: To the mixture of the product from Step C (412.0 mg, 2.5 mmol) and Et3N (0.5 mL) in CH2Cl2 at 0 C. was added chloroacetyl chloride (0.24 mL, 3.0 mmol) and DMAP (15 mg). After stirring at this temperature for 1.5 hr, the reaction mixture was washed with water and brine and dried over MgSO4. The residue was purified by chromatography on silica gel (20% ethyl acetate in hexane) to give the desired product as a white solid. LC/MS ESI found: (M+1)+=242.3.

The synthetic route of 18358-63-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pinto, Donald J.P.; Han, Wei; Hu, Zilun; Qiao, Jennifer; US2003/232804; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18358-63-9, name is Methyl 4-(methylamino)benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of Methyl 4-(methylamino)benzoate

The compound (3.1 g, 18.6 mmol) obtained in Step 4 above was dissolved in THF (37 mL). A solution prepared by dissolving LiAlH4 in THF (9.3 mL, 18.6 mmol) was slowly added thereto at 0 C. The resulting mixture was stirred for 8 hrs at 0 C, and an aqueous solution of Na2S04 was added to complete the reaction. Subsequently, a saturated aqueous solution of HC1 (50 mL) was added thereto, and the resulting mixture was stirred for 1 hr to form two different layers. The aqueous layer was extracted with EtOAc, and the organic layer was dried over Na2S04, distilled under reduced pressure, and purified by column chromatography (EtOAc/Hexane = 1/1 (v/v)) to obtain the title compound (1.4 g, 54%). 1H NMR (CDC13, 400 MHz) delta 7.21 (d, 2H), 6.61 (d, 2H), 4.56 (s, 2H), 2.85 (s, 3H)

The synthetic route of 18358-63-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; KIM, Dong Jin; YOO, Kyung Ho; KIM, Young Soo; PARK, Woong Seo; KANG, Yong Koo; KIM, Hye Yun; KIM, Yun Kyung; PARK, Ki Duk; KIM, Maeng Sup; SUH, Kwee Hyun; AHN, Young Gil; WO2013/147568; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18358-63-9, name is Methyl 4-(methylamino)benzoate, A new synthetic method of this compound is introduced below., SDS of cas: 18358-63-9

For example, some of the silylamines used in the examples below were prepared as follows from the free amine. (i) TMSCI, NEt3, CH2CI2, 17h (ii) a. n-BuLi, THF,-78C, 2 h. b. TMSCL, rt, 17h The silylamines where RN2 is sulfonyl were prepared as follows from a modified amine by heating with bis (trimethylsilyl) trifluoroacetamide (BSTFA). 0 R’ +, 1 MeCN, reflux RW NHTs + I R F CO 3 h, 95%-si- ti – SI- The silylamines were purified by vacuum distillation. Once purified, their were handled under nitrogen at all times, and stored at-20C

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED; ASTRAZENECA UK LIMITED; WO2005/90283; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 18358-63-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18358-63-9, name is Methyl 4-(methylamino)benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4.13 Lithium 4-[methyl(phenylsulfonyl)amino1benzoate; To a mixture of methyl 4-(methylamino)benzoate (1 mmol), 4-dimethylaminopyridine (2 mg), and diisopropylethylamine (1.1 mmol) in acetonitrile (3 ml) was added benzenesulfonyl chloride (1.1 mmol). The reaction mixture was stirred for 16h, and the mixture concentrated by nitrogen stream. The crude product was partitioned between 1 M HCI (aq) and ethyl acetate. The aqueous layer was extracted with ethyl acetate and the combined organic extracts were washed with 1 M HCI (aq), water, brine and dried over sodium sulfate. The solvent was removed and the crude product was purified by flash column chromatography on silica to give methyl 4- [methyl(phenylsulfonyl)amino]benzoate as a white solid (249 mg, 81 %).

The synthetic route of Methyl 4-(methylamino)benzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEDIVIR AB; WO2007/144379; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics