Category: 183322-16-9

Synthetic Route of 183322-16-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 183322-16-9, name is Ethyl 3,4-bis(2-methoxyethoxy)benzoate, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of the compound (iii) (172.6g) was dissolved in acetic acid (954.1g) and stirred until clear dissolution. Under ice conditions Concentrated sulfuric acid (33.2g). Was added dropwise 65% nitric acid (160.8g). After completion of the dropwise addition, the reaction at room temperature for about 18H, seized by HPLCMeasuring the reaction was completed. Water was added l48g, (873gX3 times) and extracted with toluene, washed with sodium bicarbonate (2mol / L) and the pH adjusted left 8Right, once, the combined organic phase was washed once with sodium bicarbonate solution and extracted with 350g of toluene saturated brine (1048g). Spin-dry solventCompound (iv) (196 · 4g), yield 99%, purity> 95%

The chemical industry reduces the impact on the environment during synthesis Ethyl 3,4-bis(2-methoxyethoxy)benzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Zhejiang Apeloa Kangyu Pharmaceutical Co.,Ltd; Shanghai Yuyuan Bio-Pharma Co. Ltd; FENG, LICHUN; LI, QIEQIE; (11 pag.)CN103709110; (2016); B;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 183322-16-9, name is Ethyl 3,4-bis(2-methoxyethoxy)benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester (15.00 g, 0.05 mol) was added into acetic acid (50 ml) to form a mixture, and while the mixture was stirred in an ice water bath, 65%-68% nitric acid (13 ml) was added to the mixture. The mixture then was stirred for 24 h at room temperature. The reaction mixture was poured into ice water (500 ml), and extracted with ethyl acetate. The organic phase was combined, washed with saturated sodium bicarbonate solution three times, washed with saturated sodium chloride solution, and then dried by anhydrous sodium sulfate. The organic phase was then filtered to obtain a filtrate. The filtrate was concentrated to obtain a brown oily liquid 2-nitro-4,5-bis(2-methoxyethoxy)ethyl benzoate (14.10 g, 82.22%).

The synthetic route of 183322-16-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen Salubris Pharmaceuticals Co., Ltd.; Shanghai Institute of Pharmaceutical Industry; LI, Jianqi; ZHANG, Zixue; XIE, Peng; ZHANG, Qingwei; EP2592083; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

183322-16-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 183322-16-9 as follows.

1.6 Synthesis of ethyl 6-nitro-3,4-bis(methoxyethoxy)benzoateThe 0.23 mol ethyl 3,4-bis(methoxyethoxy)benzoate dissolved in 230 ml of acetic acid, maintaining the temperature of the systrem at 0-5C, 60 ml concentrated nitric acid was added. warmed to room temperature for 30 min, and continue reaction for 24h. The reaction mixture was poured into the 1000 ml water, ethyl acetate extraction (5¡Á250 ml), combined with the phase, are respectively using saturated NaHCO 3 solution (3x250mL) and saturated NaCl solution (3x250mL) washing, NaSO 4 drying. Activated carbon decolourizations, revolving off a solvent to obtain oil, yield 96%

According to the analysis of related databases, Ethyl 3,4-bis(2-methoxyethoxy)benzoate, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Normal University; Qi, Chuanmin; Wang, Xiao; Li, Shilei; He, Yong; Chen, Yurong; (16 pag.)CN103193722; (2016); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics