Category: 180287-02-9

Bailey, Wade H. III et al. published their research in Collection of Czechoslovak Chemical Communications in 2002 | CAS: 180287-02-9

Methyl 2-fluoro-3-oxopentanoate (cas: 180287-02-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Methyl 2-fluoro-3-oxopentanoate

Fluorination of methyl 3-oxopentanoate (MOP) using difluorobis(fluoroxy)methane, BDM was written by Bailey, Wade H. III;Casteel, William J. Jr.;Syvret, Robert G.. And the article was included in Collection of Czechoslovak Chemical Communications in 2002.Name: Methyl 2-fluoro-3-oxopentanoate This article mentions the following:

Difluorobis(fluoroxy)methane, BDM, is an electrophilic fluorinating agent that is capable of effecting selective monofluorination of 1,3-dicarbonyls such as diketones and keto esters with very high regioselectivity. For example, in highly acidic anhydrous HF (AHF) solvent, fluorination of Me 3-oxopentanoate (MOP) with BDM provides Me 2-fluoro-3-oxopentanoate (MFOP) with 100% conversion and 95% selectivity. In mixtures of HF and methanol, fluorination conversions and selectivity are markedly lower. In comparison, direct fluorination of MOP with dilute F2 typically affords a fluorinated product that is less pure, being contaminated with radical fluorination byproducts that are difficult to sep. Fluorination of MOP with dilute mixtures of BDM and F2 is generally more selective than using dilute F2 alone. In the experiment, the researchers used many compounds, for example, Methyl 2-fluoro-3-oxopentanoate (cas: 180287-02-9Name: Methyl 2-fluoro-3-oxopentanoate).

Methyl 2-fluoro-3-oxopentanoate (cas: 180287-02-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Methyl 2-fluoro-3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics