9/15/2021 News Discovery of 18013-97-3

The synthetic route of Diethyl 2,5-dibromoterephthalate has been constantly updated, and we look forward to future research findings.

Synthetic Route of 18013-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18013-97-3, name is Diethyl 2,5-dibromoterephthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A 250 mL round bottom flask was charged with diethyl 2,5-dibromo-terephthalate (9.12 g, 24 mmol), 2-tri-n-butyltin-thieno[3,2-b]thiophene (25.76 g, 60 mmol) and tetratriphenylphosphine palladium (277.3 Mg, 0.24mmol). Nitrogen gas was purged three times, and toluene (120 mL) except oxygen was added, and the mixture was refluxed under nitrogen for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, water was added, and dichloromethane was evaporated. The mixture was separated by silica gel column chromatography using dichloromethane as eluent to give diethyl 2,5-bis(thieno[3,2-b]thiophen-2-yl)terephthalate (8.98 g, yield 75%).

The synthetic route of Diethyl 2,5-dibromoterephthalate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Ningbo Materials Technology And Engineering Institute; Fang Junfeng; Zhang Wenjun; Song Changjian; (26 pag.)CN109232604; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New learning discoveries about 18013-97-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl 2,5-dibromoterephthalate, and friends who are interested can also refer to it.

Reference of 18013-97-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18013-97-3 name is Diethyl 2,5-dibromoterephthalate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 100 mL dry three-necked flask with a magnetic rotor and a condenser, diethyl 2,5-dibromo-terephthalate (3.80 g, 10.0 mmol, 1.0 eq) was added sequentially.Phenylboronic acid (1.21 g, 10.0 mmol, 1.0 eq), tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) (570 mg, 0.5 mmol, 0.05 eq),Na2CO3 (2.12 g, 20 mmol, 2.0 eq).Nitrogen gas was distilled three times, then toluene (60.0 mL) and ethanol (20.0 mL) were added.Nitrogen gas was then bubbled for 20 minutes and the mixture was placed in a 90 C oil bath for 36 hours.The mixture was cooled to room temperature, and the solvent was evaporated under reduced pressure.Eluent (petroleum ether / dichloromethane = 3: 1-1: 1) to give 3 as a white solid 256 mg, 7% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl 2,5-dibromoterephthalate, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University of Technology; Ruisheng Optoelectric Science And Technology (Changzhou) Co., Ltd.; Li Guijie; Lou Weiwei; Huang Da; Chen Shaohai; (46 pag.)CN109678906; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The important role of C12H12Br2O4

Electric Literature of 18013-97-3, These common heterocyclic compound, 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Electric Literature of 18013-97-3, These common heterocyclic compound, 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The inventive diindenothiophene derivatives can be produced by any of the methods that are conventionally known to persons having ordinary skill in the art. For instance, the above-mentioned compound of formula (2) can be prepared by a method comprising the following steps:

Statistics shows that Diethyl 2,5-dibromoterephthalate is playing an increasingly important role. we look forward to future research findings about 18013-97-3.

Reference:
Patent; ETERNAL CHEMICAL CO., LTD.; US2010/168444; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simple exploration of Diethyl 2,5-dibromoterephthalate

Synthetic Route of 18013-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18013-97-3, name is Diethyl 2,5-dibromoterephthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthetic Route of 18013-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18013-97-3, name is Diethyl 2,5-dibromoterephthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 2 Diethyl 2,5-di(benzo[b]thiophen-4-yl)terephthalate To a mixture of magnesium turnings (0.91 g, 36 mmol) and anhydrous tetrahydrofuran (20 cm3) is added 4-bromobenzo[b]thiophene (7.0 g, 33 mmol) and the mixture heated at 75 C. for 17 hours. The resulting suspension is syringed into a solution of tributyltinchloride (16 g, 49 mmol) in anhydrous tetrahydrofuran (20 cm3) at -78 C. The ice bath is removed and the resulting mixture is stirred at 23 C. for 17 hours. The reaction mixture is quenched with water (100 cm3) and extracted with 40-60 petroleum (5*50 cm3). The combined organic phase is washed with brine (50 cm3), dried over magnesium sulphate, filtered and the solvent removed in vacuo to give crude (4-tributylstannanyl-benzo[b]thiophen-2-yl). Nitrogen gas is bubbled for an hour through a suspension of 2,5-dibromo-terephthalic acid diethyl ester (2.3 g, 6.0 mmol) in anhydrous N,N-dimethylformamide (50 cm3) and tris(dibenzylideneacetone)dipalladium(0) (0.3 g, 0.3 mmol) and tri(o-tolyl)phosphine (0.2 g, 0.6 mmol) are added. The resulting mixture is heated to 90 C. and the prepared (4-tributylstannanyl-benzo[b]thiophen-2-yl) is added. The reaction mixture is stirred at 90 C. for 17 hours. The reaction mixture is concentrated in vacuo and purified using silica gel column chromatography (gradient of 40-60 petroleum to diethyl ether) to give diethyl 2,5-di(benzo[b]thiophen-4-yl)terephthalate (0.9 g, 31%) as a white solid. 1H NMR (300 MHz, CDCl3) 8.05 (2H, s, ArH), 7.95 (2H, d, ArH, J 8.0), 7.49-7.44 (4H, m, ArH), 7.37 (2H, d, ArH, J 5.5), 7.28 (2H, d, ArH, J 5.5), 3.92 (4H, q, CH2, J 7.2), 0.72 (6H, t, 2CH3, J 7.2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 2,5-dibromoterephthalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; D’Lavari, Mansoor; Mitchell, William; Wang, Changsheng; Tierney, Steven; Sparrowe, David; US2015/144847; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of 18013-97-3

Synthetic Route of 18013-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18013-97-3, name is Diethyl 2,5-dibromoterephthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthetic Route of 18013-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18013-97-3, name is Diethyl 2,5-dibromoterephthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A 250 mL round bottom flask was charged with diethyl 2,5-dibromo-terephthalate (9.12 g, 24 mmol), 2-tri-n-butyltin-thieno[3,2-b]thiophene (25.76 g, 60 mmol) and tetratriphenylphosphine palladium (277.3 Mg, 0.24mmol). Nitrogen gas was purged three times, and toluene (120 mL) except oxygen was added, and the mixture was refluxed under nitrogen for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, water was added, and dichloromethane was evaporated. The mixture was separated by silica gel column chromatography using dichloromethane as eluent to give diethyl 2,5-bis(thieno[3,2-b]thiophen-2-yl)terephthalate (8.98 g, yield 75%).

The synthetic route of Diethyl 2,5-dibromoterephthalate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Ningbo Materials Technology And Engineering Institute; Fang Junfeng; Zhang Wenjun; Song Changjian; (26 pag.)CN109232604; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sources of common compounds: Diethyl 2,5-dibromoterephthalate

The synthetic route of Diethyl 2,5-dibromoterephthalate has been constantly updated, and we look forward to future research findings.

Related Products of 18013-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18013-97-3, name is Diethyl 2,5-dibromoterephthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2,5-Dibromo-terephthalic acid diethyl ester (20 g, 53 mmol), dibenzofuran- 1 -boronic acid (29 g, 137 mmol) and tripotassiumphosphate monohydrate (48.5 g, 160 mmol) were added to water/toluene/dioxane (1 :1 :1 , 0.5 L). The solution was saturated with argon. Palladium(ll)-acetate (1 18 mg, 0.5 mmol) and tri-o-tolyl-phosphine (480 mg, 1 .6 mmol) were added and the reaction mixture was refluxed for 16 hours. After cooling down to room temperature, toluene (500 mL) was added and the organic phase was washed with water (3 x 500 mL) and then concentrated under reduced pressure. The residue was purified by recrystallization from toluene/ethanol. Yield: 22.2 g (40 mol; 76 %).

The synthetic route of Diethyl 2,5-dibromoterephthalate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; LINGE, Rouven; RODRIGUEZ, Lara-Isabel; MEYER, Sebastian; HEIL, Holger; (112 pag.)WO2018/95888; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Continuously updated synthesis method about 18013-97-3

The synthetic route of 18013-97-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 18013-97-3, A common heterocyclic compound, 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, molecular formula is C12H12Br2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

60 g (160 mmol) of diethyl dibromoterephthalate, 43 g (320 mmol) of o-tolylboronic acid, 365 mg (0.32 mmol) of Pd(PPh3)4 and 92 g (660 mmol) of K2CO3 are heated at the boil for 4 h in 300 ml of toluene and 300 ml of water. The mixture is subsequently partitioned between toluene and water, and the organic phase is washed three times with water and dried over Na2SO4. The residue remaining is recrystallised twice from heptane to give colourless crystals. The yield is 51 g (127 mmol, 81%).

The synthetic route of 18013-97-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Patent GmbH; US2011/92701; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Analyzing the synthesis route of 18013-97-3

Statistics shows that 18013-97-3 is playing an increasingly important role. we look forward to future research findings about Diethyl 2,5-dibromoterephthalate.

18013-97-3, name is Diethyl 2,5-dibromoterephthalate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 18013-97-3

In a 100 mL Schlenck tube, tin hydride material a1′ (4.7 g) and brominated material b1′ (2.8 g) were successively added.Pd(PPh3)4 (890 mg), toluene (50 mL),Under nitrogen protection, heated under reflux for 40 hours,After removing the toluene by vacuum evaporation and passing through the silica gel column,Dichloromethane as eluent gave the product c1′ (2.5 g, yield 74%) as a yellow solid.

Statistics shows that 18013-97-3 is playing an increasingly important role. we look forward to future research findings about Diethyl 2,5-dibromoterephthalate.

Reference:
Patent; (31 pag.)CN107652304; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simple exploration of 18013-97-3

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Diethyl 2,5-dibromoterephthalate.

Adding some certain compound to certain chemical reactions, such as: 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18013-97-3. 18013-97-3

To the crude was added anhydrous Lambda/,/V-dimethylformamide (100 cm3), 2,5-dibromo-terephthalic acid diethyl ester (1 1 .0 g, 29 mmol) and bis(triphenylphosphine)palladium(ll) dichloride (612 mg, 0.87 mmol) and the mixture heated at 100 C for 2 hours. The mixture allowed to cool to 23 C, concentrated in vacuo and passed through a plug of silica (dichloromethane) to give a solid which was triturated in methanol. The solid collected by filtration to give 2,5-bis-thieno[2,3-b]thiophen-2-yl- terephthalic acid diethyl ester (1 1 .68 g, 81 %) as a yellow solid. 1H-NMR (400 MHz, CDCIs) 1 .13 (6H, t, J 7.1 ), 4.24 (4H, q, J 7.1 ), 7.24 (2H, d, J 5.2), 7.26 (2H, s), 7.37 (2H, d, J 5.2), 7.88 (2H, s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Diethyl 2,5-dibromoterephthalate.

Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; HEARD, Kane; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (260 pag.)WO2019/52935; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Share a compound : 18013-97-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 18013-97-3, other downstream synthetic routes, hurry up and to see.

A common compound: 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 18013-97-3

Under nitrogen protection,Diethyl 2,5-dibromoterephthalate (2g, 5.26mmol), compound 1 (7.03, 13.68mmol), and dry toluene (40mL) were added to a 100mL two-necked flask, and nitrogen was bubbled through to remove it. After half an hour of oxygen, Pd (PPh3) 4 (116 mg, 0.1 mmol) was quickly added, and the reaction solution was heated to 110 C and refluxed for 24 hours. After the reaction was stopped, the reaction solution was cooled to room temperature, and the toluene solvent was distilled off with a rotary evaporator. It was then separated and purified with a chromatography column using petroleum ether / dichloromethane as the eluent (volume ratio of 3: 2) to obtain Compound 2 (2.85 g, 81.2%) as a brown solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 18013-97-3, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing University of Science and Technology; Yu Jiangsheng; Tang Weihua; Zhang Zhuohan; Liu Xin; Zhou Jie; Geng Renyong; Yang Linqiang; (25 pag.)CN110606856; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics