Category: 17994-94-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17994-94-4, name is Methyl 7-aminoheptanoate hydrochloride belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Methyl 7-aminoheptanoate hydrochloride

Methyl 7-(4-(2-oxo-2-(quinolin-8-ylamino)ethyl)benzamido)heptarioate, 69.; Compound 68 (200 mg, 0.65 mmol) was dissolved in CH2CI2 (20 mL) under argon. To this added 7-aminoheptanoic acid methyl ester (as the hydrochloride, 140 mg, 0.72 mmol), Et3N (73 mg, 0.72 mmol) and EDC (138 mg, 0.72 mmol) and the mixture was allowed to stir overnight at it. Added water and worked up with CH2CI2, the residue purified through flash column (silica gel 230-400 mesh, 80% ethyl acetate in hexanes) to ohtain 69 as white solid (238 mg, 82%). NMR (400 MHz, CDC13): S = 1.35-1.37 (m, 4 H), 1.58-1.64 (m, 4 H), 2.29 (t, 2 , J = 7.2 Hz), 3.43 (q, 2 H, J = 6.8 Hz), 3.64 (s, 3 H), 3.92 (s, 2 H), 6.18 (s, 1 H), 7.41-7.51 (m, 5 H), 7.77 (d, 2 H, J = 8 Hz), 8.15 (d, 1 H, J = 8 Hz), 8.71-8.73 (m, 2 H), 9.95 (s, 1 H). I3C NMR (75 MHz, CDC13): delta = 24.7, 26.5, 28.6, 33.8, 39.9, 44.7, 51.3, 116.3, 121.6, 121.8, 127.0, 127.6, 127.7, 129.4, 133.7, 134.0, 136.2, 137.9, 138.1, 148.2, 167.3, 168.9, 174.1 LRMS Calcd for C26H29N3O4: 448.21 Found: 447.90.

The synthetic route of 17994-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; BRESLOW, Ronald; MARKS, Paul, A.; ABHILASH, K., G.; WANG, Jianing; WO2011/146855; (2011); A1;,
Ester – Wikipedia,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17994-94-4 as follows. Recommanded Product: 17994-94-4

General procedure: To a mixture of aldehyde (1 mmol) and amine/amine hydrochloride (1 mmol) in anhydrous CH2Cl2 (10 mL) was added triethylamine (2.5 mmol) at rt, and the resulting solution was stirred vigorously for 1 h. To this was then added (Boc)2O (1.2 mmol) followed by sodium triacetoxyborohydride (2 mmol). The reaction was stirred for an additional 4 h at rt, quenched with saturated NaHCO3 solution, and extracted with CH2Cl2. The combined organic fractions were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude residue was purified by flash chromatography (95:05?50:50, hexanes/EtOAc) to afford the N-Boc secondary amine. Most of the title compounds were present as a mixture of rotational isomers in their 1H and 13C NMR spectra.

According to the analysis of related databases, 17994-94-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Neelarapu, Raghupathi; Petukhov, Pavel A.; Tetrahedron; vol. 68; 35; (2012); p. 7056 – 7062;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 17994-94-4, The chemical industry reduces the impact on the environment during synthesis 17994-94-4, name is Methyl 7-aminoheptanoate hydrochloride, I believe this compound will play a more active role in future production and life.

Methyl 7-(4-(l^-dioxo-l,3-bis(quinolin-8-ylamino)pr pan-2-yl)benzamido)heptanoate, 60.; To compound 59 (200 mg, 0.42 mmol) in (?(? (20 mL) at rt added 7-aminoheptanoic acid methyl ester (as the hydrochloride, 90 mg, 0.46 mmol), Et^ (47 mg, 0.46 mmol) and EDC (89 mg, 0.46 mmol). The mixture was allowed to stir at rt for 12 h. Water was added and the mixture was worked up with Combined organic extracts were dried with anhydNa2S04, solvent removed under vacuum and the residue was purified by column chromatography (silica gel 230-400 mesh, 80% ethyl acetate in hexanes as the eluent) to afford 70 as a white solid (202 mg, 78%).Mp = 178-180 C. NMR (300 MHz, CDC13): delta = 1.34-1.36 (m, 4 H), 1.59-1.62 (m, 4 H), 2.29 (t, 2 H, J = 5.7 Hz), 3.42 (m, 2 H), 3.64 (s, 3 H), 5.03 (s, 1 H), 6.14 (s, 1 H), 7.43-7.47 (m, 2 H), 7.53 (d, 4 H, J = 3.3 Hz), 7.84 (dd, 4 H, /, = 6.3 Hz, J2 = 15.3 Hz), 8.15 (d, 2 H, J = 6 Hz), 8.82-8.86 (m, 4 H), 10.98 (s, 2 H). I3C NMR (75 MHz, CDC13): delta = 24.7, 26.5, 28.7, 29.4, 33.9, 40.0, 51.5, 62.3, 117.1, 121.7, 122.4, 127.1, 127.9, 128.7, 134.1, 134.8, 136.2, 138.0, 138.7, 148.7, 166.6, 167.0, 174.2. HRMS (FAB+) Calcd for C36H36O5N5 = 618.2638, Found = 618.2712.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 7-aminoheptanoate hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; BRESLOW, Ronald; MARKS, Paul, A.; ABHILASH, K., G.; WANG, Jianing; WO2011/146855; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 17994-94-4, A common heterocyclic compound, 17994-94-4, name is Methyl 7-aminoheptanoate hydrochloride, molecular formula is C8H18ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of aldehyde (1 mmol) and amine/amine hydrochloride (1 mmol) in anhydrous CH2Cl2 (10 mL) was added triethylamine (2.5 mmol) at rt, and the resulting solution was stirred vigorously for 1 h. To this was then added (Boc)2O (1.2 mmol) followed by sodium triacetoxyborohydride (2 mmol). The reaction was stirred for an additional 4 h at rt, quenched with saturated NaHCO3 solution, and extracted with CH2Cl2. The combined organic fractions were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude residue was purified by flash chromatography (95:05?50:50, hexanes/EtOAc) to afford the N-Boc secondary amine. Most of the title compounds were present as a mixture of rotational isomers in their 1H and 13C NMR spectra.

The synthetic route of 17994-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Neelarapu, Raghupathi; Petukhov, Pavel A.; Tetrahedron; vol. 68; 35; (2012); p. 7056 – 7062;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 17994-94-4, These common heterocyclic compound, 17994-94-4, name is Methyl 7-aminoheptanoate hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 7-(2-trimethylsilanyl-ethoxycarbonylamino)-heptanoate Methyl 7-amino-heptanoate hydrochloride (7.0 g, 35.9 mmol) was dissolved in dichloromethane (75.4 mL), and N-[2-(trimethylsilyl)ethoxycarbonyloxy]succinimide (10.0 g, 38.6 mmol) and triethylamine (10 mL, 71.7 mmol) were then added at room temperature. The mixture was stirred for 5 hours, and then quenched with water (100 mL), and separated. The aqueous layer was extracted with dichloromethane (50 mL). The organic layers were combined, then dried over anhydrous sodium sulfate, and filtered. The solvent was distilled off under reduced pressure to obtain 8.89 g (29.3 mmol, 82% yield) of methyl 7-(2-trimethylsilanyl-ethoxycarbonylamino)-heptanoate. 1H-NMR (CDCl3) delta: 0.04 (9H, s), 0.97 (2H, br.t, J = 8.4 Hz), 1.20-1.76 (8H, m), 2.31 (2H, t, J = 7.4 Hz), 3.07-3.23 (2H, m), 3.67 (3H, s), 4.14 (2H, br.t, J = 8.4 Hz), 4.50-4.70 (1H, m)

Statistics shows that Methyl 7-aminoheptanoate hydrochloride is playing an increasingly important role. we look forward to future research findings about 17994-94-4.

Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; KOHCHI, Yasunori; NAKAMA, Kimitaka; KOMIYAMA, Susumu; WATANABE, Fumio; EP2886530; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 17994-94-4, These common heterocyclic compound, 17994-94-4, name is Methyl 7-aminoheptanoate hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

7-(4-Butyl-benzylamino)-heptanoic acid methyl ester. A solution of 7-amino-heptanoic acid methyl ester hydrochloride, prepared of Preparation 1, (1.12 g, 5.9 mmol), 4-butyl-benzaldehyde (0.915 g, 5.65 mmol), and triethylamine (0.83 mL, 5.98 mmol) in 20 mL MeOH was stirred at room temperature for 3 hours. After cooling to 0 C., NaBH4 (0.342 g, 9.04 mmol) was added and the reaction was stirred for 15 minutes at room temperature. The mixture was quenched with 1:1 NaHCO3:H2O and the MeOH was removed in vacuo. The resulting residue was diluted with CH2Cl2 and the organic solution was washed with water and brine, dried over MgSO4, filtered, and concentrated in vacuo to afford the title compound of Step A (1.4 g). 1H NMR (400 MHz, CDCl3) delta 7.08-7.38 (m, 4H), 3.62 (s, 2H), 3.29 (s, 3H), 2.52-2.66 (m, 4H), 2.25 (t, 2H), 1.53-1.63 (m, 6H), 1.25-1.40 (m, 6H), 0.85 (t, 3H); MS 306 (M+1).

Statistics shows that Methyl 7-aminoheptanoate hydrochloride is playing an increasingly important role. we look forward to future research findings about 17994-94-4.

Reference:
Patent; Pfizer Inc.; US2005/203086; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17994-94-4, name is Methyl 7-aminoheptanoate hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Methyl 7-aminoheptanoate hydrochloride

(b) Carbostyril-6-sulfonyl chloride (corresponding to 54) (138mg, 0.57mmol) and then subsequently Et3N (114mg, 3.24mmol) in CH2Cl2 (0.5ml) were added to a solution of 7-aminoheptanoic acid methyl ester hydrochloride (142mg, 0.73mmol) in CH2Cl2 (2ml) at room temperature. The reaction mixture was stirred for 16h at room temperature. H2O (10ml), AcOEt (10ml), and n-hexane (10ml) were then sequentially added to the mixture. The precipitate was gathered, washed with H2O, and dried to afford a pink solid (127mg, 0.35mmol, y. 61%). 1H NMR (300MHz/DMSO-d6) delta 1.15-1.20 (4H, m, CH2¡Á2), 1.29-1.44 (4H, m, CH2¡Á2), 2.22 (2H, t, J=7.2Hz, CH2), 2.72 (2H, q, J=6.0Hz, NCH2), 3.56 (3H, s, OCH3), 6.61 (1H, d, J=9.6Hz, CH=), 7.43 (1H, d, J=8.7Hz ArH), 7.53 (1H, t, J=5.9Hz, NH), 7.84 (1H, dd, J=8.7, 2.1Hz ArH), 8.07 (1H, d, J=9.6Hz, CH=), 8.13 (1H, d, J=2.1Hz, ArH), 12.01 (1H, br, NH).

According to the analysis of related databases, 17994-94-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tashima, Toshihiko; Murata, Hiroaki; Kodama, Hidehiko; Bioorganic and Medicinal Chemistry; vol. 22; 14; (2014); p. 3720 – 3731;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics