In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 179688-27-8 as follows. Formula: C15H23NO6
To a stirred solution of 15.7 g (50 mmol) of ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate (Pfizer patent WO 96130347) in 50 ml of DMF at 0C was added phosphorous oxychloride (5.6 ml, 60 mmol) during 15 m. The resulting solution was heated at 55C for 45 m, cooled, diluted with methylene chloride, and treated at 0C with 200 ml of N/1 sodium hydroxide during 2 m. The organic layer was separated and washed at 0C with water. The solution was dried and evaporated with added toluene present to give 18.4 g of amber oil; NMR (CDCl3) delta 3.02 (s, Me2N).
According to the analysis of related databases, 179688-27-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wyeth Holdings Corporation; EP973746; (2003); B1;,
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