Category: 17920-23-9

Synthesis of polyfluoroalkyl substituted cyclopropane derivatives was written by Wu, Fan-Hong;Gu, Song;Huang, Wei-Yuan. And the article was included in Youji Huaxue in 2006.Product Details of 17920-23-9 This article mentions the following:

A new convenient synthesis of a series of polyfluoroalkyl substituted cyclopropane derivatives was achieved by the reaction of polyfluoroalkyl iodides with di-Et (allyl)malonate in the presence of sodium dithionite in 45-55% yields. The reaction of allyl acetoacetate with polyfluoroalkyl iodides under similar conditions gave the corresponding adducts. Treatment of the latter with base gave the desired cyclization products, such as, for example, 2-(3-chloro-2,2,3,3-tetrafluoropropyl)-1,1-cyclopropanedicarboxylic acid di-Et ester. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Product Details of 17920-23-9).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 17920-23-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One pot cascade synthesis of fused heterocycles from furan-tethered terminal alkynes and aldehydes in the presence of amines and CuBr was written by Zhang, Yan-Yan;Hao, Jian;Shi, Min. And the article was included in Organic Chemistry Frontiers in 2015.Recommanded Product: 17920-23-9 This article mentions the following:

A one-pot protocol for the construction of complex heterocycles through furan-tethered terminal alkynes, aldehydes, amines and CuBr upon heating was developed, giving the cycloadducts in moderate to high yields along with moderate to good regioselectivities. The reactions proceed through a two-component domino reaction, including allenation and subsequent intramol. Diels-Alder reaction. A wide range of aliphatic or aromatic aldehydes and furan-tethered terminal alkynes were well-tolerated, enriching the chem. of the intramol. Diels-Alder reaction related to furan. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Recommanded Product: 17920-23-9).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 17920-23-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

1,6-Heptadiynes disubstituted at position 4 by acetyl, ethoxycarbonyl, and nitrile groups was written by Plouin, Dominque;Glenat, Rene. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1972.Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:

The title compounds, RR1C(CH2C椤氬挵H)2 (I), were prepared in 84-92% yields by condensing HC椤氬挵CH2Br with CH2RR1 in K2CO3-Me2CO. The formation of minor products, substituted furans, and MeCOCH(CH2C椤氬挵H)2, was discussed. Four I (R = COMe, CO2Et; R1 = COMe, CO2Et, CN) were prepared In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cyclization of alk-5-ynyl ketones promoted by Tf₂NH and In(OTf)₃: selective synthesis of 5- and 7-membered carbocycles was written by Kinoshita, Hidenori;Miyama, Chika;Miura, Katsukiyo. And the article was included in Tetrahedron Letters in 2016.Computed Properties of C10H14O4 This article mentions the following:

Combined use of Tf₂NH and In(OTf)₃ effectively promotes the cyclization of alk-5-ynyl ketones to cyclopent-1-enyl ketones at 30 鎺矯 [e.g., I 閳?II (77%)]. Single use of Tf₂NH or In(OTf)₃ requires heating at 50 鎺矯 for efficient cyclization. The In(OTf)₃-promoted reaction of certain alk-5-ynyl ketones gives cyclohept-2-enones mainly. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Computed Properties of C10H14O4).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C10H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemistry of natural substances. VII. Furoquinoline derivatives by condensation of ethyl 2-propynyl malonate with aromatic amines was written by Reisch, Johannes. And the article was included in Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft in 1967.Category: esters-buliding-blocks This article mentions the following:

Under the reaction conditions which are stated by Baker, Lappin, and Riegel (1946) for the preparation of 3-substituted 4-hydroxyquinolin-2-one, malonic acid diarylamides and not 4-hydroxyquinolinones were obtained. By variation of the synthesis from prop-2-ynylmallonic ester and PhNH2 or MeOC5H4-NH2 resp. 5′-methylnordictamine and 5′-methylnorpseudodictaamine or 5′-methylnorfagarine (Ia) and 5′-methylnorpseudofagarine (Ib) resp. were prepared (Method A) A mixture of 11 g. di-Et prop-2-ynylmalonate (I) and 4.7 g. PhNH2 in 25 ml. Ph2O were refluxed 1 hr. to give 66% prop-2-ynylmalonic acid (II) dianilide (IIa), m. 217鎺?(EtOH). (Method B). To 3.8 g. freshly distilled PHNH2 in 150 ml. absolute Et2O was dropped 2 g. prop-2-ynylmalonic acid dichloride in 20 ml. Et2O with stirring and ice cooling to obtain 90% IIa. According to method A was prepared 48% of the corresponding di-O-anisidide, m. 147鎺?(EtOH) of II; 54% of the cyclohexylmalonic acid (III) dianilide, m. 303鎺?(EtOH) and from 6.65 g. di-Et cyclohexylmalonate (IV) and 3.1 g. p-MeOC6H4NH2, 3 g. di-p-anisidide derivative, m. 289-90鎺?(EtOH) of III, beside 1 g. p-anisidide Et ester derivative, m. 158-60鎺?(aqueous EtOH) of III. Heating 6 g. di-Et propylmalonate and 6 g. PhNH2 1 hr. at 190-200鎺?gave 50% propylmalonic acid dianilide (V), m. 200鎺?(EtOH). Hydrogenation of IIa in 80% MeOH at 0鎺?and 760 mm. gave V quant. A mixture of 6.65 g. IV and 2.32 g. PhNH2 in 12.5 ml. Ph2O was heated on the descending cooler until 2.5 ml. EtOH was distilled to give 83% 3-cyclohexyl-4-hydroxy-2(1H)-quinolinone (VI), m. 238-4鎺?(EtOH). Analogously prepared were 90% 6-methoxy derivative m. 235-6鎺?(EtOH), of VI, and 3-propyl-4-hydroxy-2(1H)quinolinone, m. 235鎺? A mixture of 22 g. I and 9.3 g. PhNH2 in 50 ml. was heated on the descending cooler until 10 ml. EtOH was distilled to obtain 74% 2-methylfuro[3,2-c]quinolinone (VII), identified by ir spectroscopy. Also obtained was 16% 2-methylfuro[2,3-b]quinolin-4-one (VIII), m. 275鎺?(HCONMe2H2O). Analogously were prepared 74% Ib m. 248-52鎺?(sublimes), and 13.5% Ia, m. 261鎺? In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Category: esters-buliding-blocks).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Regiospecific Synthesis of Bicyclo- and Heterobicyclo-gem-difluorocyclobutenes Using Functionalized Fluoroallenes and a Novel Mo-Catalyzed Intramolecular [2 + 2] Cycloaddition Reaction was written by Shen, Qilong;Hammond, Gerald B.. And the article was included in Journal of the American Chemical Society in 2002.Computed Properties of C10H14O4 This article mentions the following:

The synthesis of functionalized gem-difluoroallenes served as a platform for an unprecedented molybdenum-catalyzed intramol. allene-alkyne [2+2]-cycloaddition that produced difluorobicyclooctadienes, a hitherto unknown class of bicyclo- and heterobicyclo-CF₂-containing cyclobutenes. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Computed Properties of C10H14O4).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C10H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

1,6-Heptadiynes disubstituted at position 4 by acetyl, ethoxycarbonyl, and nitrile groups was written by Plouin, Dominque;Glenat, Rene. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1972.Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:

The title compounds, RR1C(CH2C顚咰H)2 (I), were prepared in 84-92% yields by condensing HC顚咰CH2Br with CH2RR1 in K2CO3-Me2CO. The formation of minor products, substituted furans, and MeCOCH(CH2C顚咰H)2, was discussed. Four I (R = COMe, CO2Et; R1 = COMe, CO2Et, CN) were prepared In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cyclization of alk-5-ynyl ketones promoted by Tf₂NH and In(OTf)₃: selective synthesis of 5- and 7-membered carbocycles was written by Kinoshita, Hidenori;Miyama, Chika;Miura, Katsukiyo. And the article was included in Tetrahedron Letters in 2016.Computed Properties of C10H14O4 This article mentions the following:

Combined use of Tf₂NH and In(OTf)₃ effectively promotes the cyclization of alk-5-ynyl ketones to cyclopent-1-enyl ketones at 30 掳C [e.g., I 鈫?II (77%)]. Single use of Tf₂NH or In(OTf)₃ requires heating at 50 掳C for efficient cyclization. The In(OTf)₃-promoted reaction of certain alk-5-ynyl ketones gives cyclohept-2-enones mainly. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Computed Properties of C10H14O4).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C10H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemistry of natural substances. VII. Furoquinoline derivatives by condensation of ethyl 2-propynyl malonate with aromatic amines was written by Reisch, Johannes. And the article was included in Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft in 1967.Category: esters-buliding-blocks This article mentions the following:

Under the reaction conditions which are stated by Baker, Lappin, and Riegel (1946) for the preparation of 3-substituted 4-hydroxyquinolin-2-one, malonic acid diarylamides and not 4-hydroxyquinolinones were obtained. By variation of the synthesis from prop-2-ynylmallonic ester and PhNH2 or MeOC5H4-NH2 resp. 5′-methylnordictamine and 5′-methylnorpseudodictaamine or 5′-methylnorfagarine (Ia) and 5′-methylnorpseudofagarine (Ib) resp. were prepared (Method A) A mixture of 11 g. di-Et prop-2-ynylmalonate (I) and 4.7 g. PhNH2 in 25 ml. Ph2O were refluxed 1 hr. to give 66% prop-2-ynylmalonic acid (II) dianilide (IIa), m. 217掳 (EtOH). (Method B). To 3.8 g. freshly distilled PHNH2 in 150 ml. absolute Et2O was dropped 2 g. prop-2-ynylmalonic acid dichloride in 20 ml. Et2O with stirring and ice cooling to obtain 90% IIa. According to method A was prepared 48% of the corresponding di-O-anisidide, m. 147掳 (EtOH) of II; 54% of the cyclohexylmalonic acid (III) dianilide, m. 303掳 (EtOH) and from 6.65 g. di-Et cyclohexylmalonate (IV) and 3.1 g. p-MeOC6H4NH2, 3 g. di-p-anisidide derivative, m. 289-90掳 (EtOH) of III, beside 1 g. p-anisidide Et ester derivative, m. 158-60掳 (aqueous EtOH) of III. Heating 6 g. di-Et propylmalonate and 6 g. PhNH2 1 hr. at 190-200掳 gave 50% propylmalonic acid dianilide (V), m. 200掳 (EtOH). Hydrogenation of IIa in 80% MeOH at 0掳 and 760 mm. gave V quant. A mixture of 6.65 g. IV and 2.32 g. PhNH2 in 12.5 ml. Ph2O was heated on the descending cooler until 2.5 ml. EtOH was distilled to give 83% 3-cyclohexyl-4-hydroxy-2(1H)-quinolinone (VI), m. 238-4掳 (EtOH). Analogously prepared were 90% 6-methoxy derivative m. 235-6掳 (EtOH), of VI, and 3-propyl-4-hydroxy-2(1H)quinolinone, m. 235掳. A mixture of 22 g. I and 9.3 g. PhNH2 in 50 ml. was heated on the descending cooler until 10 ml. EtOH was distilled to obtain 74% 2-methylfuro[3,2-c]quinolinone (VII), identified by ir spectroscopy. Also obtained was 16% 2-methylfuro[2,3-b]quinolin-4-one (VIII), m. 275掳 (HCONMe2H2O). Analogously were prepared 74% Ib m. 248-52掳 (sublimes), and 13.5% Ia, m. 261掳. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Category: esters-buliding-blocks).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 纬-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Regiospecific Synthesis of Bicyclo- and Heterobicyclo-gem-difluorocyclobutenes Using Functionalized Fluoroallenes and a Novel Mo-Catalyzed Intramolecular [2 + 2] Cycloaddition Reaction was written by Shen, Qilong;Hammond, Gerald B.. And the article was included in Journal of the American Chemical Society in 2002.Computed Properties of C10H14O4 This article mentions the following:

The synthesis of functionalized gem-difluoroallenes served as a platform for an unprecedented molybdenum-catalyzed intramol. allene-alkyne [2+2]-cycloaddition that produced difluorobicyclooctadienes, a hitherto unknown class of bicyclo- and heterobicyclo-CF₂-containing cyclobutenes. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Computed Properties of C10H14O4).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C10H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics