Category: 178396-31-1

Application of 178396-31-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Cobalt(III)/Rhodium(III)-Catalyzed Regio- and Stereoselective Allylation of 8-methylquinoline via sp3 C-H Activation.

Regio- and stereoselective benzylic allylation of 8-methylquinolines with (per)fluoroalkyl olefins was realized via benzylic C-H activation and subsequent C-F cleavage. Both cobalt(III) and rhodium(III) catalysts can effect this transformation in good to high efficiency. The Rh(III)-catalyzed system proceeded under moderate conditions with decent substrates scope, providing (Z)-alkenyl fluorides with good to excellent regio- and stereoselectivity.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-8-methylquinoline( cas:178396-31-1 ) is researched.Application of 178396-31-1.Chen, Lijin; Zhou, Zhenfei; Zhang, Saifei; Li, Xiaoqian; Ma, Xuebing; Dong, Jiaxing published the article 《Palladium(II)-catalyzed oxidative C(sp3)-P bond formation via C(sp3)-H bond activation》 about this compound( cas:178396-31-1 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: quinoline phosphonate phosphinate phosphine oxide preparation CH activation copuling; oxidative coupling secondary phosphinyl compound methylquinoline preparation phosphonate phosphinate. Let’s learn more about this compound (cas:178396-31-1).

8-Methylquinolines undergo side-chain C-H-activation and phosphinylation in palladium-catalyzed oxidative coupling with secondary phosphinyl compounds, phosphonates, phosphinates and phosphine oxides X2P(O)H, forming the corresponding 8-phosphinylmethylquinolines 8-X2P(O)CH2[C9H6-nN]Rn (X = alkoxy, aryl; R = H, halo, Me, aryl, NO2, alkenyl, alkynyl). Disclosed herein is a Pd(II)-catalyzed C(sp3)-H/P-H oxidative cross-coupling reaction between 8-methylquinolines with H-phosphonates or diarylphosphine oxides via chelation-assisted C(sp3)-H bond activation. The protocol exhibits a relatively broad functional-group tolerance and exclusive chemo- and regioselectivity. Furthermore, detailed mechanistic studies support the proposed reaction pathway.

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Chen, You-Ke; Kang, Yan-Shang; Xu, Hua-Jin; Zhang, Ping; Zhao, Jing; Li, Tiantian; Sun, Wei-Yin; Lu, Yi published an article about the compound: 6-Bromo-8-methylquinoline( cas:178396-31-1,SMILESS:CC1=CC(Br)=CC2=C1N=CC=C2 ).Name: 6-Bromo-8-methylquinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:178396-31-1) through the article.

A mild and efficient Rh(III)-catalyzed aliphatic C-H acetoxylation directed by quinolines has been developed with widespread functional groups, including various halogens, which usually can provide precursors for further organic synthesis but easily results in selectivity issues in the Pd- and Ni-catalyzed reaction. Interestingly, Ac2O plays an essential role in promoting the transformation.

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Category: esters-buliding-blocks. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Rhodium(III)-Catalyzed C(sp3)-H Alkylation of 8-Methylquinolines with Maleimides. Author is Han, Sangil; Park, Jihye; Kim, Saegun; Lee, Suk Hun; Sharma, Satyasheel; Mishra, Neeraj Kumar; Jung, Young Hoon; Kim, In Su.

The rhodium(III)-catalyzed cross-coupling reaction of 8-methylquinolines and maleimides is described. In contrast to the C(sp2)-H functionalization, a first catalytic functionalization of sp3 C-H bonds with maleimides is reported. This protocol provides a facile access to various succinimide scaffolds on 8-methylquinolines via a direct C-H cleavage approach.

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Formula: C10H8BrN. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Rhodium(III)-Catalyzed Oxidative C(sp3)-H Alkenylation of 8-Methylquinolines with Maleimides Under Aerobic Conditions. Author is Shan, Baode; Kang, Baotao; Song, Mingyue; Wang, Rui; Chen, Guozhu; Li, Cuncheng; Zhao, Huaiqing.

A rhodium(III)-catalyzed C(sp3)-H alkenylation of 8-methylquinolines I (R = H, 5-Br, 7-F, 7-OMe, etc.) with electron-deficient maleimides II (R1 = H, Me, tert-Bu, 4-chlorophenyl, etc.) has been accomplished with the combination of copper acetate, 2,2,6,6-tetramethylpiperidine-1-oxyl and oxygen as the oxidant. A variety of maleimides II react with various 8-methylquinolines I to furnish the corresponding alkenylated products III in moderate to good yields.

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SDS of cas: 178396-31-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Palladium-Catalyzed Direct α-Ketoesterification of 8-Methylquinoline Derivatives with α-Ketoacids via Dehydrogenation Coupling Reaction. Author is Li, Lesong; Zhang, Feng; Deng, Guo-Jun; Gong, Hang.

A direct, regiospecific, and efficient palladium-catalyzed α-ketoesterification of 8-methylquinoline derivatives to generate α-ketoester has been discovered. This reaction is conducted at a mild temperature, free of peroxide, and compatible with air, and various α-ketoester were achieved with good yields. Importantly, this reaction can be easily amplified to gram level using only 1 mol % of the palladium catalyst, indicating that there is the potential for further reduction of the amount of catalyst loading required for large-scale production

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Cp*Rh(III)-catalyzed C(sp3)-H alkylation of 8-methylquinolines in aqueous media, the main research direction is oxoalkylquinoline preparation; methylquinoline allylic alc alkylation rhodium catalyst.Related Products of 178396-31-1.

The rhodium(III)-catalyzed cross-coupling reaction of 8-methylquinolines with a range of allylic alcs. in water is described. This approach leads to the synthesis of various γ-quinolinyl carbonyl compounds, which are synthetically useful precursors for the construction of bioactive tetrahydroquinoline and azasteroid derivatives

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 178396-31-1, is researched, Molecular C10H8BrN, about Rh-Catalyzed Direct Amination of Unactivated C(sp3)-H bond with Anthranils Under Mild Conditions, the main research direction is rhodium catalyzed amination carbon hydrogen bond methylquinoline anthranil; C−H activation; amination; anthranils; heterocycles; rhodium.Reference of 6-Bromo-8-methylquinoline.

C-N bond formation is of great significance due to the ubiquity of nitrogen-containing compounds Here, a mild and efficient RhIII-catalyzed C(sp3)-H aryl amination reaction is reported. Anthranil is employed as the nitrogen source with 100 % atom efficiency. This C-H amination reaction exhibits broad substrate scope without using any external oxidants. Mechanistic studies including rhodacycle intermediates, H-D exchange, kinetic isotope effect (KIE) experiments, and in situ IR are presented. Thus, e.g., Rh/Ag-catalyzed amination of 8-methylquinoline with anthranil (I) in presence of PivOH additive afforded II (95%).

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Recommanded Product: 6-Bromo-8-methylquinoline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Cobalt-catalyzed ring-opening addition of azabenzonorbornadienes via C(sp3)-H bond activation of 8-methylquinoline. Author is Tan, Heng; Khan, Ruhima; Xu, Dandan; Zhou, Yongyun; Zhang, Xuexin; Shi, Guangrui; Fan, Baomin.

The first ring-opening addition of a benzylic C(sp3)-H bond to azabenzonorbornadienes is demonstrated. The reaction proceeded under the catalytic system of [Cp*CoI2(CO)], AgSbF6 and Fe(OAc)2 in PhOMe. The methodol. showed a good substrate scope with up to 96% yield. The relative configuration of the product was determined as cis-configuration by X-ray crystallog.

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Computed Properties of C10H8BrN. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Palladium-Catalyzed sp3 C-H Nitration of 8-Methylquinolines. Author is Zhang, Wei; Ren, Shaobo; Zhang, Jian; Liu, Yunkui.

Palladium-catalyzed nitration of 8-methylquinolines with t-BuONO to give 8-(nitromethyl)quinolines I [R1 = H, 6-Cl, 5-Me, etc; R2 = H, 3-Ph.] in moderate to excellent yields has been developed involving an sp3 C-H bond activation. The resulting (nitromethyl)quinolines could be selectively reduced to (1,2,3,4-tetrahydroquinolin-8-yl)methanamines by NaBH4 in the presence of a catalytic amount of NiCl2·6H2O.

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