Category: 178396-31-1

Application of 178396-31-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Rhodium(III)-catalyzed alkylation of primary C(sp3)-H bonds with α-diazocarbonyl compounds. Author is Hou, Wei; Yang, Yaxi; Wu, Yunxiang; Feng, Huijin; Li, Yuanchao; Zhou, Bing.

Rh(III)-catalyzed intermol. chelation-assisted insertion of carbenes derived from α-diazocarbonyl compounds into non-acidic primary sp3 C-H bonds, for the first time, was reported under mild reaction conditions, thus affording a good complement to previous metal-carbenoid-induced primary C(sp3)-H insertion reactions. This method opened up a new avenue for primary sp3 C-H functionalization with α-diazocarbonyl compounds

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Application of 178396-31-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Cp*RhIII-Catalyzed Sterically Controlled C(sp3)-H Selective Mono- and Diarylation of 8-Methylquinolines with Organoborons. Author is Kumar, Rakesh; Parmar, Diksha; Gupta, Shiv Shankar; Chandra, Devesh; Dhiman, Ankit Kumar; Sharma, Upendra.

The Cp*Rh(III)-catalyzed regioselective and chemoselective C-H arylation of 8-methylquinolines with organoboron reagents were disclosed to give quinoline derivatives I [R = H, 5-Me, 7-Cl, etc.; R1 = H, Ph, 4-ClC6H4, etc.; R2 = Ph, 4-MeOC6H4, 4-ClC6H4, etc.]. Late-stage monoarylation of oxime derivative santonin gave corresponding monoarylated oxime derivative II and gram-scale synthesis of compound I [R = 7-Cl; R1 = H; R2 = 4-ClC6H4] was also been carried out. A mechanistic study revealed that the current reaction was first order with respect to both reactants and a five-membered rhodacycle intermediate may be involved in the catalytic cycle.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Cobalt(III)-Catalyzed Alkylation of Primary C(sp3)-H Bonds with Diazo Compounds, published in 2017, which mentions a compound: 178396-31-1, Name is 6-Bromo-8-methylquinoline, Molecular C10H8BrN, Application In Synthesis of 6-Bromo-8-methylquinoline.

Chelation-assisted C(sp2)-H metalation/carbenoid insertion has been well investigated. However, the analogous carbene functionalization of C(sp3)-H bonds remains a great challenge. Here we report the first cobalt(III)-catalyzed alkylation of 8-methylquinolines with diazo compounds through primary C(sp3)-H cobaltation/carbenoid insertion. The reaction is highly efficient, scalable and tolerates a variety of functional groups. Furthermore, the unique protocol can be applied to the synthesis of azatricyclic antibiotic compounds

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ACS Catalysis called Mild Acylation of C(sp3)-H and C(sp2)-H Bonds under Redox-Neutral Rh(III) Catalysis, Author is Yu, Songjie; Li, Yingzi; Kong, Lingheng; Zhou, Xukai; Tang, Guodong; Lan, Yu; Li, Xingwei, which mentions a compound: 178396-31-1, SMILESS is CC1=CC(Br)=CC2=C1N=CC=C2, Molecular C10H8BrN, Synthetic Route of C10H8BrN.

Carbonyl groups are ubiquitous in functional mols. Although C-H bond acylation has been well-studied via different mechanisms, transition-metal-catalyzed redox-neutral C(sp3)-H acylation under mild conditions is unprecedented. In this work, ketene is designed as a acylating reagent for both C(sp3)-H and C(sp2)-H bonds under Rh(III) catalysis, affording a diverse array of carbonyl compounds in high yields and high atom economy under mild conditions.

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Recommanded Product: 178396-31-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides. Author is Kumar, Rakesh; Kumar, Rohit; Chandra, Devesh; Sharma, Upendra.

The cobalt(III)-catalyzed C(sp3)-H bond alkylation of 8-Me quinoline with maleimides is reported. In contrast to the rhodium-catalyzed method, in the current cobalt-catalyzed method, a catalytic amount of acid is used, and importantly, it is also applicable to secondary C(sp3)-H bond alkylation. The developed methodol. is applicable for N-alkyl- and N-aryl-substituted maleimides and unsubstituted maleimides, and it also tolerates the variety of functional groups on the 8-Me quinoline moiety. Atom-economy and high regioselectivity with good to excellent yields of the alkylated products under mild reaction conditions are important features of this method.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 178396-31-1, is researched, Molecular C10H8BrN, about RhIII-Catalyzed Direct Heteroarylation of C(sp3)-H and C(sp2)-H Bonds in Heterocycles with N-Heteroaromatic Boronates, the main research direction is methyl quinoline heteroaryl boronate rhodium catalyst heteroarylation; heteroaryl methyl quinoline preparation; phenyl pyridine heteroaryl boronate rhodium catalyst heteroarylation; heteroaromatic phenyl pyridine preparation.Recommanded Product: 6-Bromo-8-methylquinoline.

A RhIII-catalyzed heteroarylation of C(sp3)-H and C(sp2)-H bonds in heterocycles with organoboron reagents were disclosed. This protocol displayed high efficiency and excellent functional group tolerance. A range of heterocyclic boronates with strong coordinating atoms, including pyridine, pyrimidine, pyrazole, thiophene and furan derivatives, extensively served as the coupling reagents. The direct heteroarylation method could supply potential application in terms of the synthesis of drug mols. with multiple heterocycles.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Rhodium(III)-catalyzed alkenylation reactions of 8-methylquinolines with alkynes by C(sp3)-H activation, the main research direction is methylquinoline alkyne alkenylation carbon hydrogen bond activation rhodium catalyst; allyl quinoline preparation mol crystal structure; CH activation; alkynes; regioselectivity; rhodium; synthetic methods.Safety of 6-Bromo-8-methylquinoline.

The alkenylation reactions of 8-methylquinolines with alkynes, catalyzed by [{Cp*RhCl2}2], proceeds efficiently to give 8-allylquinolines in good yields by C(sp3)-H bond activation. These reactions are highly regio- and stereoselective. A catalytically competent five-membered rhodacycle was structurally characterized, thus revealing a key intermediate in the catalytic cycle. The structures of the compounds were determined by spectroscopic data and confirmed by single crystal x-ray diffraction anal. of 8-(2,3-diphenylallyl)quinoline (I) and pentamethylcyclopentadienylchlororhodium complex of 8-methylquinoline (II). The crystallog. data were deposited at the Cambridge Crystallog. Data Center as supplementary publication number CCDC 978941 for I and CCDC 978942 for II.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Bromo-8-methylquinoline(SMILESS: CC1=CC(Br)=CC2=C1N=CC=C2,cas:178396-31-1) is researched.Reference of cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II). The article 《Cobalt(III)-Catalyzed 1,4-Addition of C(sp3)-H Bonds to Maleimides》 in relation to this compound, is published in Synlett. Let’s take a look at the latest research on this compound (cas:178396-31-1).

In this manuscript, an efficient and atom-economic protocol for synthesis of addition products I (R = H, 7-OCH3, 5-Cl, etc.; R1 = Me, Et, Bn, 4-FC6H4, etc.) via alkylation reactions of 8-methylquinolines II with maleimides such as N-methylmaleimide, N-phenylmaleimide, N-benzylmaleimide, etc. is presented. The reaction exhibits exceptional reactivity, satisfactory yields, excellent chemo- and regioselectivity, and tolerates a variety of functional groups.

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Related Products of 178396-31-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Iodonium Ylides as Carbene Precursors in Rh(III)-Catalyzed C-H Activation. Author is Jiang, Yuqin; Li, Pengfei; Zhao, Jie; Liu, Bingxian; Li, Xingwei.

The rhodium(III)-catalyzed coupling of C-H substrates with iodonium ylides has been realized for the efficient synthesis of diverse cyclic skeletons, where the iodonium ylides have been identified as efficient and outstanding carbene precursors. The reaction systems are applicable to both sp2 and sp3 C-H substrates under mild and redox-neutral conditions. The catalyst loading can be as low as 0.5 mol % in a gram-scale reaction. Representative products exhibit cytotoxicity toward human cancer cells at nanomolar levels.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Bromo-8-methylquinoline(SMILESS: CC1=CC(Br)=CC2=C1N=CC=C2,cas:178396-31-1) is researched.Electric Literature of C11H23Br. The article 《Rhodium(III)-Catalyzed Intermolecular Amidation with Azides via C(sp3)-H Functionalization》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:178396-31-1).

The amidation reactions of 8-methylquinolines with azides catalyzed by a cationic rhodium(III) complex proceed efficiently to give quinolin-8-ylmethanamine derivatives in good yields via C(sp3)-H bond activation under external oxidant-free conditions. A catalytically competent five-membered rhodacycle has been isolated and characterized, revealing a key intermediate in the catalytic cycle.

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