Synthetic Route of 17435-72-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17435-72-2, name is Ethyl 2-(bromomethyl)acrylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 6 Synthesis of ethyl 2-Phenoxymethylacrylate A solution of ethyl 2-bromomethylacrylate (2.00 g, 10.4 mmol, ref: Villieras, J. and Rambaud, M. Synthesis, 1982, 914) and phenol(975 mg, 1.0 eq) in dry THF (20 ML) under N2 at 0 C. was treated with anhydrous K2CO3 (1.43 g, 1.0 mol eq).. No reaction was observed for 1 h.. anhydrous DMF (20 ML) was added and stirred for 2 h at 0 C. and for 1 h at room temperature.. After evaporation of DMF, water(100 ML) was added, and the reaction was extracted with ethyl acetate (100 ML*2).. The organic extract was washed with brine (100 ML), dried (anh. Na2SO4), filtered and concentrated.. Flash chromatography (40% CH2Cl2/hexanes) gave 1.712 g (80%) of the title compound. 1H-NMR (500 MHz, CDCl3) delta 7.30 (2H, yt, J=7.3 Hz), 6.99-6.96 (3H, m), 6.41 (1H, s), 6.01 (1H, s), 4.78 (2H, s), 4.27 (2H, q, J=7.33 Hz).
The synthetic route of Ethyl 2-(bromomethyl)acrylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem Investment Ltd.; US6747050; (2004); B1;,
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