Category: 1732-08-7

Adding a certain compound to certain chemical reactions, such as: 1732-08-7, name is Dimethyl pimelate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1732-08-7, category: esters-buliding-blocks

Add 25000 ml of tetrahydrofuran to a 50-liter glass reactor and start stirring.Add 1500g lithium tetrahydroaluminate when cooling to 5C,Then, a mixture of 5000 g of dimethyl pimelate and 5000 ml of tetrahydrofuran was transferred to a dropping funnel.When the temperature of the reaction flask dropped to 5C, it began to be added dropwise.Control the temperature at 5 C, after the completion of the drop 1hThe mixture was slowly heated to room temperature and stirred for 1.5 hours. After the sample was taken, no raw material remained. It was qualified. The temperature was lowered to 5 C., and 1500 g of water, 1500 g of 15% sodium hydroxide solution, and 1500 g of water were added dropwise. The filtrate was concentrated to give 3360 g 1, Crude 7-heptanediol, crude 1,7-heptanediol was distilled under reduced pressure by an oil pump, and the oil bath temperature was 105C.The gas-phase collection temperature is 74C, giving 3201 g of 1,7-heptanediol,Content 99.6%, yield 95.3%;

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Reference:
Patent; Haimen Huaxiang Pharmaceutical Technology Co., Ltd.; Wu Tiansheng; Zhou Guang; Xu Benquan; (5 pag.)CN107417496; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1732-08-7, name is Dimethyl pimelate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1732-08-7, Application In Synthesis of Dimethyl pimelate

Dimethyl pimelate (3.76 g, 20 mmol) was added dropwise to a suspension of NaH(1.06g, 26.6 mmol, 60% in mineral oil) in dry THF (20 mL). The resulting slurry wasstirred at RT overnight. The reaction was quenched with water (5 mL), extracted withEtOAc (20 mL× 3), washed with brine, dried (Na2SO4), and concentrated undervaccum. The residue was chromatographed with petrolum ether-EtOAc (20:1) to give the desired methyl 2-cyclohexanonecarboxylate as a colorless oil. (2.42 g, 77%).

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Reference:
Article; Qian, Hua; Gu, Guoxian; Zhou, Qinghai; Lu, Jiaxiang; Chung, Lung Wa; Zhang, Xumu; Synlett; vol. 29; 1; (2018); p. 51 – 56;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

1732-08-7, name is Dimethyl pimelate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Dimethyl pimelate

To a 500 ml four-necked flask equipped with a stirring, a thermometer, a reflux condenser, and a constant pressure dropping funnel, 100 g of chloroform, 18.8 g (0.1 mol) of dimethyl 1,7-pimelate, and 0.6 g of 40 wt% were added. Hydrobromic acid, 72.0 g of bromine and 50 g of chloroform were added dropwise at 30-35 C. After the completion of the dropwise addition, the reaction was stirred at 30-35 C for 7 hours, cooled to 20-25 C, and purged with nitrogen for 2 hours. 17 wt% ammonia water, stirring reaction at 60-65 C for 6 hours, then, cooling to 20-25 C, adding 20 g of 30 wt% hydrogen peroxide, stirring at 30-35 C for 4 hours, adding 45 g of 20 wt% aqueous sodium hydroxide solution, The reaction was stirred at 30-35 C for 4 hours, layered, and the organic phase was washed twice with water. Each time 20 g of water, the aqueous phase is combined, the pH of the aqueous phase is adjusted to 2.5-2.0 with hydrochloric acid, filtered, and dried to obtain 15.1 g of a white solid 2,6-pyridinedicarboxylic acid, the liquid phase purity is 99.5%, and the product yield is 90.4%. .

The synthetic route of 1732-08-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Ju Lizhu; Zhang Mingfeng; Lv Qiangsan; Qi Yuxin; (7 pag.)CN110229096; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics