Category: 16982-21-1

Product Details of 16982-21-1In 2018 ,《Synthesis and QSAR study of novel thiazole moieties having antioxidant activity》 was published in International Journal of Pharmaceutical Sciences and Research. The article was written by Kashid, G. A.; Singh, S. K.; Saravanan, J.. The article contains the following contents:

Thiazoles derivatives are an important class of heterocyclic compounds, reported to possess a wide spectrum of biol. activities. Moreover, thiazole nucleus occupies a very important place in the field of antioxidant agents. The above observations prompted us to synthesize some novel thiazole derivatives with various substitutions at along with heterocyclic rings in the same framework for synergistic action. We here in report the synthesis, antioxidant screening & QSAR studies of the new title compounds Concentrated research on N-((Substituted) benzylidene)-4-(4-chlorophenyl) thiazole-2-carbohydrazides I [R = 4-Cl; R1 = 4-Me, 4-Cl, 3-nitro, etc.] & were synthesized, screened for antioxidant activities & QSAR studies. All new entities have good yield and results. From antioxidant activity results, it was observed that the compounds with both electron donating and electron withdrawing groups on the aldehydic Ph ring influenced the activity. Among all the compounds, compounds I [R = 4-Cl, R1 = 4-hydroxy-3-methoxy, 3,4,5-trihydroxy, 4-methoxy, 4-Cl, 4-hydroxy] showed the good % inhibition and were found to be more significant compound among all the compounds tested. Compounds GS-5i-j were showed moderate % inhibition and were found to be significant among all the tested compounds 2D & 3D-QSAR models with moderate to high predictive ability of thiazole derivatives were derived. The role of hydrophobicity as a 3D property was confirmed and also electrostatic and steric effects were found to contribute to antioxidant activity. The experimental process involved the reaction of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Product Details of 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 16982-21-1

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2010,Gaikwad, Sudhakar A.; Patil, Amol A.; Deshmukh, Madhukar B. published 《An efficient, uncatalyzed, and rapid synthesis of thiazoles and aminothiazoles under microwave irradiation and investigation of their biological activity》.Phosphorus, Sulfur and Silicon and the Related Elements published the findings.COA of Formula: C4H7NO2S The information in the text is summarized as follows:

A convenient method for the synthesis of thiazoles by treatment of α-bromoketones with thioamides (Hantzsch synthesis) in the absence of catalysts under microwave irradiation was developed. The products were formed rapidly in excellent yields. An efficiency comparison of time, yield, and effort clearly proved the microwave technique to be superior. The structures of the newly synthesized compounds were characterized by spectroscopic data and elemental analyses. The synthesized compounds were tested for their biol. activity. Depending on the substituents, some of the thiazoles exhibit very good antibacterial or antifungal activity. In the experiment, the researchers used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1COA of Formula: C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.COA of Formula: C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2016,Chaitra, Turuvekere K.; Mohana, Kikkeri N.; Gurudatt, Doddahosuru M.; Tandon, Harmesh C. published 《Inhibition activity of new thiazole hydrazones towards mild steel corrosion in acid media by thermodynamic, electrochemical and quantum chemical methods》.Journal of the Taiwan Institute of Chemical Engineers published the findings.SDS of cas: 16982-21-1 The information in the text is summarized as follows:

The mild steel anti-corrosion potential by newly synthesized thiazole hydrazones, 4-(4-methoxy-phenyl)-thiazole-2-carboxylic acid benzylidene-hydrazide (TH-1), 4-(4-methoxy-phenyl)-thiazole-2-carboxylic acid (3-hydroxy-benzylidene)-hydrazide (TH-2) and 4-(4-methoxy-phenyl)-thiazole-2-carboxylic acid (4-hydroxy-benzylidene)-hydrazide (TH-3) in 0.5 M hydrochloric acid was studied by gravimetric and electrochem. techniques. Thermodn. parameters were evaluated for activation and adsorption processes. Adsorption of the inhibitors followed Langmuir isotherm. Electrochem. measurements showed that addition of inhibitors simultaneously decreased corrosion c.d. and double layer capacitance but increased charge transfer resistance. Potentiodynamic polarization studies revealed that thiazole hydrazones effectively suppressed both the anodic and cathodic processes of mild steel corrosion in acid solution and hence acted as mixed-type inhibitors. Quantum chem. parameters like EHOMO, ΔE, softness and hardness were very well correlated with exptl. data. SEM characterized the film formed on the mild steel. In addition to this study using Ethyl 2-amino-2-thioxoacetate, there are many other studies that have used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1SDS of cas: 16982-21-1) was used in this study.

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.SDS of cas: 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Parallel synthesis of derivatives of 1H-1,2,4-triazole-3-carboxylic acids with heterocyclic substituents at position 5》 was written by Grebenkina, Lyubov E.; Matveev, Andrey V.; Chudinov, Mikhail V.. Product Details of 16982-21-1 And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020. The article conveys some information:

A mild universal method for the synthesis of derivatives of 5-substituted 1H-1,2,4-triazole-3-carboxylic acids I (R = tetrahydrofuran-2-yl, furan-3-yl, tetrahydropyran-2-yl, thiophen-3-yl, pyridin-2-yl, etc.; R1 = OEt, NH2) from a single precursor, Et β-N-Boc-oxalamidrazone, has been proposed. The method was applied for the parallel synthesis of a library of 1H-1,2,4-triazole-3-carboxamides I (R1 = NH2) with heterocyclic substituents at position 5. After reading the article, we found that the author used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Product Details of 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Prediction of agonist, partial agonist and full antagonist of H. pylori TlpB utilizing molecular docking》 was written by Kumar, Mohit; Nandi, Sisir. Recommanded Product: 16982-21-1 And the article was included in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2020. The article conveys some information:

Helicobacter pylori infections are one of the major issues that produce gastric and duodenal ulcers due to chronic gastritis. Deforestation and global warming may cause ecol. imbalance followed by climatic change due to enhanced temperature This may contribute to abdominal discomfort and gastritis specifically in case of in taking a lot of non-vegetables, fast and junk foods, oily and spicy foods. H. pylori, which is asymptomatic for almost 80% of people’s gastrointestinal tract (G.I.T.), may be stimulated due to chronic gastritis. It has been associated with colorectal polyps and cancer, if not treated well. Therefore, attention has been paid to predict some urea compounds as H. pylori antagonists utilizing structure-based mol. docking. Earlier reports of such work do not exist. The results came from multiple reactions, including the reaction of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Recommanded Product: 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics