Category: 16982-21-1

In 2015,Burdi, Douglas F.; Campbell, John E.; Wang, Jun; Zhao, Sufang; Zhong, Hua; Wei, Jianfeng; Campbell, Una; Shao, Liming; Herman, Lee; Koch, Patrick; Jones, Philip G.; Hewitt, Michael C. published 《Evolution and synthesis of novel orally bioavailable inhibitors of PDE10A》.Bioorganic & Medicinal Chemistry Letters published the findings.Application of 16982-21-1 The information in the text is summarized as follows:

The design and synthesis of highly potent, selective orally bioavailable inhibitors of PDE10A is reported. Starting with an active compound of modest potency from a small focused screen, we were able to evolve this series to a lead mol. with high potency and selectivity vs. other PDEs using structure-based design. A systematic refinement of ADME properties during lead optimization led to a lead compound with good half-life that was brain penetrant. Compound I was highly potent vs. PDE10A (IC50 = 1.0 nM), demonstrated high selectivity (>1000-fold) against other PDEs and was efficacious when dosed orally in a rat model of psychosis, PCP-induced hyperlocomotion with an EC50 of 1 mg/kg. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Application of 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Organic & Biomolecular Chemistry included an article by Putta, V. P. Rama Kishore; Gujjarappa, Raghuram; Tyagi, Ujjawal; Pujar, Prasad P.; Malakar, Chandi C.. Reference of Ethyl 2-amino-2-thioxoacetate. The article was titled 《A metal- and base-free domino protocol for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines and related scaffolds》. The information in the text is summarized as follows:

Efficient protocols have been described for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines, 2-arylthiazin-4-ones and diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones. These transformations were successfully driven towards product formation under mild acid catalyzed reaction conditions at room temperature using 2-aminoaryl/hetero-aryl alkyl alcs. and amides as substrates. The merits of the present methods also rely on the easy access of rarely explored bioactive scaffolds like 1,3-benzoselenazine derivatives, for which well-documented methods are rarely known in the literature. A broad range of substrates with both electron-rich and electron-deficient groups were well-tolerated under the developed conditions to furnish the desired products in yields up to 98%. The scope of the devised method was not only restricted to the synthesis of 1,3-benzoselenazines, but it was further extended towards the synthesis of 1,3-benzothiazines, 1,3-benzothiazinones and the corresponding eight-membered N-heterocycles such as diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones. In the experiment, the researchers used many compounds, for example, Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Reference of Ethyl 2-amino-2-thioxoacetate)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of Ethyl 2-amino-2-thioxoacetate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: Ethyl 2-amino-2-thioxoacetateIn 2008 ,《Synthesis of 5-(Thiazol-5-yl)-4,5-dihydroisoxazoles from 3-Chloropentane-2,4-dione》 was published in Journal of Combinatorial Chemistry. The article was written by Milinkevich, Kristin A.; Ye, Long; Kurth, Mark J.. The article contains the following contents:

Condensation of 3-chloropentane-2,4-dione with thioamides gives 1-(thiazol-5-yl)ethanones and subsequent Wittig olefination, followed by nitrile oxide 1,3-dipolar cycloaddition to the resulting prop-1-en-2-yl moiety, delivers racemic 5-(thiazol-5-yl)-4,5-dihydroisoxazoles, e.g. I. When this thiazole and isoxazoline diheterocyclic scaffold has a carboethoxy substituent at C2 of the thiazole ring, aminolysis provides for effective diversification. A 50-member library of various 5-(thiazol-5-yl)-4,5-dihydroisoxazoles is reported. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Name: Ethyl 2-amino-2-thioxoacetate)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Name: Ethyl 2-amino-2-thioxoacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2010,Tyagarajan, Sriram; Chakravarty, Prasun K.; Zhou, Bishan; Fisher, Michael H.; Wyvratt, Mathew J.; Lyons, Kathy; Klatt, Tracy; Li, Xiaohua; Kumar, Sanjeev; Williams, Brande; Felix, John; Priest, Birgit T.; Brochu, Richard M.; Warren, Vivien; Smith, McHardy; Garcia, Maria; Kaczorowski, Gregory J.; Martin, William J.; Abbadie, Catherine; McGowan, Erin; Jochnowitz, Nina; Parsons, William H. published 《Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers》.Bioorganic & Medicinal Chemistry Letters published the findings.Electric Literature of C4H7NO2S The information in the text is summarized as follows:

Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low mol. weight biaryl substituted imidazole, e.g. I, oxazole, e.g. II, and thiazole, e.g. III, carboxamides were identified with good in vitro and in vivo potency. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Electric Literature of C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

SDS of cas: 16982-21-1In 2008 ,《Synthesis and reactions of some new substituted thiazolidin-4-ones derivatives with antioxidant properties》 was published in Organic Chemistry: An Indian Journal. The article was written by El Nzhawy, Ahmed O. H.; Ramla, Mostafa M.; Khalifa, Nagy M.; Abdulla, Mohamed M.. The article contains the following contents:

Several hetero substituted 2-(4-fluorophenyl)thiazolidin-4-one derivatives, e.g., I, have been synthesized. The newly prepared series of substituted thiazolodinone derivatives were screened for their in vitro antioxidant activity. The detailed synthesis and antioxidant activity data are reported. Structures of the compounds have been established by elemental analyses and spectral data. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1SDS of cas: 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.SDS of cas: 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach》 was written by Steeneck, Christoph; Gege, Christian; Kinzel, Olaf; Albers, Michael; Kleymann, Gerald; Schlueter, Thomas; Schulz, Andreas; Xue, Xiaohua; Cummings, Maxwell D.; Fourie, Anne M.; Leonard, Kristi A.; Scott, Brian; Edwards, James P.; Hoffmann, Thomas; Goldberg, Steven D.. Name: Ethyl 2-amino-2-thioxoacetate And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

Starting from previously identified thiazole-2-carboxamides exemplified by compound I, two new series of RORγt inverse agonists with significantly improved aqueous solubility, ADME parameters and oral PK properties were discovered. These scaffolds were identified from a bioisosteric amide replacement approach. Amongst the variety of heterocycles explored, a 1,3,4-oxadiazole led to compounds with the best overall profile for SAR development and in vivo exploration. In an ex vivo mouse PD model, concentration dependent efficacy was demonstrated and compounds II and III were profiled in a 5-day rat tolerability study.Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Name: Ethyl 2-amino-2-thioxoacetate) was used in this study.

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: Ethyl 2-amino-2-thioxoacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,Bartolome-Nebreda, Jose Manuel; Conde-Ceide, Susana; Delgado, Francisca; Iturrino, Laura; Pastor, Joaquin; Pena, Miguel Angel; Trabanco, Andres A.; Tresadern, Gary; Wassvik, Carola M.; Stauffer, Shaun R.; Jadhav, Satyawan; Gogi, Kiran; Vinson, Paige N.; Noetzel, Meredith J.; Days, Emily; Weaver, C. David; Lindsley, Craig W.; Niswender, Colleen M.; Jones, Carrie K.; Conn, P. Jeffrey; Rombouts, Frederik; Lavreysen, Hilde; Macdonald, Gregor J.; Mackie, Claire; Steckler, Thomas published 《Dihydrothiazolopyridone Derivatives as a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu5) Receptor》.Journal of Medicinal Chemistry published the findings.Formula: C4H7NO2S The information in the text is summarized as follows:

Starting from a singleton chromanone high throughput screening (HTS) hit, we describe a focused medicinal chem. optimization effort leading to the identification of a novel series of phenoxymethyl-dihydrothiazolopyridone derivatives as selective pos. allosteric modulators (PAMs) of the metabotropic glutamate 5 (mGlu5) receptor. These dihydrothiazolopyridones potentiate receptor responses in recombinant systems. In vitro and in vivo drug metabolism and pharmacokinetic (DMPK) evaluation allowed us to select compound (I) for its assessment in a preclin. animal screen of possible antipsychotic activity. I was able to reverse amphetamine-induced hyperlocomotion in rats in a dose-dependent manner without showing any significant motor impairment or overt neurol. side effects at comparable doses. Evolution of our medicinal chem. program, structure activity, and properties relationships (SAR and SPR) anal. as well as a detailed profile for optimized mGlu5 receptor PAM I are described. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Formula: C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Formula: C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2016,Chudinov, Mikhail V.; Prutkov, Alexander N.; Matveev, Andrey V.; Grebenkina, Lyubov E.; Konstantinova, Irina D.; Berezovskaya, Yulia V. published 《An alternative route to the arylvinyltriazole nucleosides》.Bioorganic & Medicinal Chemistry Letters published the findings.Synthetic Route of C4H7NO2S The information in the text is summarized as follows:

A new pathway to synthesis of arylvinyl ribavirin analogs is developed which makes it possible to obtain not only trans- but also cis-isomers at vinyl bond. By this route eight ribavirin 5-arylvinyl analogs are synthesized and their antiviral activity is evaluated.Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Synthetic Route of C4H7NO2S) was used in this study.

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Synthetic Route of C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of C4H7NO2SIn 2013 ,《Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors》 was published in European Journal of Medicinal Chemistry. The article was written by Kadam, Kishorkumar S.; Jadhav, Ravindra D.; Kandre, Shivaji; Guha, Tandra; Reddy, M. Mahesh Kumar; Brahma, Manoja K.; Deshmukh, Nitin J.; Dixit, Amol; Doshi, Lalit; Srinivasan, Shaila; Devle, Jayendra; Damre, Anagha; Nemmani, Kumar V. S.; Gupte, Amol; Sharma, Rajiv. The article contains the following contents:

Biphenyl carboxylic acids, exemplified by compound I, are known potent inhibitors of diacylglycerol acyltransferase, DGAT1, an enzyme involved in the final committed step of triglyceride biosynthesis. We have synthesized and evaluated 2-phenylthiazole, 4-phenylthiazole, and 5-phenylthiazole analogs as DGAT1 inhibitors. The 5-phenylthiazole series exhibited potent DGAT1 inhibition when evaluated using an in vitro enzymic assay and an in vivo fat tolerance test in mice. Compound II (IC50 = 23 nM) exhibiting promising oral pharmacokinetic parameters (AUCinf = 7058 ng*h/mL, T1/2 = 0.83 h) coupled with 87 percent reduction of plasma triglycerides in vivo may serve as a lead for developing newer anti-obesity agents. In the experimental materials used by the author, we found Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Synthetic Route of C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Synthetic Route of C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2003,Samaritoni, Jack G.; Demeter, David A.; Gifford, James M.; Watson, Gerald B.; Kempe, Margaret S.; Bruce, Timothy J. published 《Dihydropiperazine Neonicotinoid Compounds. Synthesis and Insecticidal Activity》.Journal of Agricultural and Food Chemistry published the findings.Formula: C4H7NO2S The information in the text is summarized as follows:

Various isomeric piperazines were prepared successfully via regioselective monothionation of their resp. diones. Preparation of the precursor unsym. N-substituted piperazinediones from readily available diamines is the key to this selectivity. The piperazine ring system, as exemplified in I [X = NCN, Y = O, Z = H2, R1 = Me; (II)] and III (R2 = 2-chloro-1,3-thiazol-5-yl), has been shown to be a suitable bioisosteric replacement for the imidazolidine ring system contained in neonicotinoid compounds However, placement of the cyanoimino electron-withdrawing group further removed from the pyridine ring, as in I (X = O, Y = NCN, Z = H2, R1 = H), or relocation of the carbonyl group, as in I (X = NCN, Y = H2, Z = O, R1 = Me), results in significantly decreased bioisosterism. The piperazine ring system of II and III (R = 2-chloro-1,3-thiazol-5-yl) also lends a degree of rigidity to the mol. that is not offered by the inactive acyclic counterpart 2-[(6-chloropyridin-3-yl)-methyl-(methyl)amino]-2-(cyanoimino)-N,N-dimethylacetamide. A pharmacophore model is proposed that qual. explains the results on the basis of good overlap of the key pharmacophore elements of II and imidacloprid; the less active regioisomers feature a smaller degree of overlap. The experimental process involved the reaction of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Formula: C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics