Recommanded Product: 169759-79-9On October 24, 2019 ,《One-pot synthesis of 2-substituted thieno[3,2-b]indoles from 3-aminothiophene-2-carboxylates through in situ generated 3-aminothiophenes》 was published in Tetrahedron Letters. The article was written by Irgashev, Roman A.; Steparuk, Alexander S.; Rusinov, Gennady L.. The article contains the following contents:
A convenient protocol for one-pot synthesis of thieno[3,2-b]indoles, bearing aromatic, thien-2-yl or styryl fragments at C-2 position, from easily accessible 5-substituted 3-aminothiophene-2-carboxylates using the Fischer indolization reaction was developed. Two main steps of this approach were the saponification of the starting 3-aminoesters with sodium hydroxide and next treatment of the crude 3-aminoacids sodium salts with arylhydrazines in glacial acetic acid solution The latter step included in-situ decarboxylation of the freed 3-aminothiophene-2-carboxylic acids to the 3-aminothiophenes and their acid promoted reaction with arylhydrazines to initially form arylhydrazones of 5-substituted thiophene-3(2H)-ones which smoothly cause indolization to afford the desired thieno[3,2-b]indoles. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-amino-[2,2′-bithiophene]-5-carboxylate(cas: 169759-79-9Recommanded Product: 169759-79-9)
Methyl 4-amino-[2,2′-bithiophene]-5-carboxylate(cas: 169759-79-9) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 169759-79-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics