Category: 16413-26-6

Amidinyl Radical Formation through Anodic N-H Bond Cleavage and Its Application in Aromatic C-H Bond Functionalization was written by Zhao, Huai-Bo;Hou, Zhong-Wei;Liu, Zhan-Jiang;Zhou, Ze-Feng;Song, Jinshuai;Xu, Hai-Chao. And the article was included in Angewandte Chemie, International Edition in 2017.Reference of 16413-26-6 This article mentions the following:

We report herein an atom-economical and sustainable approach to access amidinyl radical intermediates through the anodic cleavage of N-H bonds. The resulting nitrogen-centered radicals undergo cyclizations with (hetero)arenes, followed by rearomatization, to afford functionalized tetracyclic benzimidazoles, e.g., I (X-rays crystal structure shown), in a highly straightforward and efficient manner. This metal- and reagent-free C-H/N-H cross-coupling reaction exhibits a broad substrate scope and proceeds with high chemoselectivity. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Reference of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 2-arylimidazo[4,5-d][1,2,3]triazoles from a 4-nitroimidazol-5-yl phosphoramidate and aryl isocyanates was written by Taher, A.;Eichenseher, S.;Weaver, G. W.. And the article was included in Tetrahedron Letters in 2000.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:

The synthesis of a series of 2-aryl-2H,4H-imidazo[4,5-d][1,2,3]triazoles is reported. These compounds are obtained in moderate to good yield by reaction of tri-Et N-1-ethyl-2-methyl-4-nitro-1H-imidazol-5-yl phosphoramidate with aryl isocyanates. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds was written by Zhou, Ya;Beeler, Aaron B.;Cho, Sanghyun;Wang, Yuehong;Franzblau, Scott G.;Snyder, John K.. And the article was included in Journal of Combinatorial Chemistry in 2008.Related Products of 16413-26-6 This article mentions the following:

The chem. of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds I [R = H, R¹ = Me, R² = Ph, CH₂OPh, n-Bu; R¹ = Ph, R² = 2-Me-4-MeOC₆H₃], synthesized by intramol. cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compds I [R = (R)-PhCH(Me)NHCO, 4-MeOC₆H₄NHCO, 4-NCC₆H₄SO₂, R¹ = Ph, R² = 2-Me-4-MeOC₆H₃]. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities was written by Keles Atici, Rueveyde;Dogan, Senguel Dilem;Guenduez, Miyase Gozde;Krishna, Vagolu Siva;Chebaiki, Melina;Homberset, Haavard;Lherbet, Christian;Mourey, Lionel;Toenjum, Tone. And the article was included in Drug Development Research in 2022.Formula: C8H4N2O This article mentions the following:

The recent emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) has complicated and significantly slowed efforts to eradicate and/or reduce the worldwide incidence of life-threatening acute and chronic cases of tuberculosis. To overcome this setback, researchers have increased the intensity of their work to identify new small-mol. compounds that are expected to remain efficacious antimicrobials against Mtb. Here, we describe our effort to apply the principles of mol. hybridization to synthesize 16 compounds carrying thiophene and thiazole rings beside the core urea functionality (TTU1-TTU16). Following extensive structural characterization, the obtained compounds were initially evaluated for their antimycobacterial activity against Mtb H37Rv. Subsequently, three derivatives standing out with their anti-Mtb activity profiles and low cytotoxicity (TTU5, TTU6, and TTU12) were tested on isoniazid-resistant clin. isolates carrying katG and inhA mutations. Addnl., due to their pharmacophore similarities to the well-known InhA inhibitors, the mols. were screened for their enoyl acyl carrier protein reductase (InhA) inhibitory potentials. Mol. docking studies were performed to support the exptl. enzyme inhibition data. Finally, drug-likeness of the selected compounds was established by theor. calculations of physicochem. descriptors. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Formula: C8H4N2O).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C8H4N2O

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists was written by De Lucca, George V.;Kim, Ui T.;Johnson, Curt;Vargo, Brian J.;Welch, Patricia K.;Covington, Maryanne;Davies, Paul;Solomon, Kimberly A.;Newton, Robert C.;Trainor, George L.;Decicco, Carl P.;Ko, Soo S.. And the article was included in Journal of Medicinal Chemistry in 2002.Name: 3-Cyanophenylisocyanate This article mentions the following:

Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca²⁺ mobilization and chemotaxis of human eosinophils. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Name: 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

D-Glucose as a multivalent chiral scaffold for combinatorial chemistry was written by Opatz, Till;Kallus, Christopher;Wunberg, Tobias;Schmidt, Wolfgang;Henke, Stefan;Kunz, Horst. And the article was included in Carbohydrate Research in 2002.Related Products of 16413-26-6 This article mentions the following:

Due to their high d. of functional groups and their availability in a variety of diastereomeric forms, monosaccharides are considered attractive scaffolds for combinatorial chem. that allow the attachment and defined spatial alignment of up to five different pharmacophoric groups. For their application in combinatorial syntheses on solid phase, a set of selectively removable hydroxy protecting groups in combination with a cleavable anchor is required. Herein, we report on the construction and use of a versatile multivalent glucose building block for parallel synthesis on the solid phase. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

D-Glucose as a multivalent chiral scaffold for combinatorial chemistry was written by Opatz, Till;Kallus, Christopher;Wunberg, Tobias;Schmidt, Wolfgang;Henke, Stefan;Kunz, Horst. And the article was included in Carbohydrate Research in 2002.Related Products of 16413-26-6 This article mentions the following:

Due to their high d. of functional groups and their availability in a variety of diastereomeric forms, monosaccharides are considered attractive scaffolds for combinatorial chem. that allow the attachment and defined spatial alignment of up to five different pharmacophoric groups. For their application in combinatorial syntheses on solid phase, a set of selectively removable hydroxy protecting groups in combination with a cleavable anchor is required. Herein, we report on the construction and use of a versatile multivalent glucose building block for parallel synthesis on the solid phase. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics