Category: 16413-26-6

Mishra, R. C. et al. published their research in Combinatorial Chemistry and High Throughput Screening in 2003 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of 3-Cyanophenylisocyanate

DBU-assisted cyclorelease elimination: Combinatorial synthesis and 绾?glutamyl cysteine synthetase and glutathione-S-transferase modulatory effect of C-nucleoside analogs was written by Mishra, R. C.;Tewari, Neetu;Arora, Kavita;Ahmad, Rumana;Tripathi, R. P.;Tiwari, V. K.;Walter, R. D.;Srivastava, A. K.. And the article was included in Combinatorial Chemistry and High Throughput Screening in 2003.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:

A combinatorial library of 60 C- nucleoside analogs was synthesized by sequential coupling of building blocks followed by cyclative cleavage with DBU in an efficient manner. Only DMSO soluble compounds were tested for their modulatory effect against filarial 绾?glutamyl cysteine synthetase (绾?GCase) and glutathione-S-transferases (GSTs). Several compounds were found to be weak inhibitors of filarial 绾?GCase, whereas, most of them stimulated filarial GSTs. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chowdhury, Sarwat et al. published their research in Journal of Medicinal Chemistry in 2018 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 16413-26-6

Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss was written by Chowdhury, Sarwat;Owens, Kelly N.;Herr, R. Jason;Jiang, Qin;Chen, Xinchao;Johnson, Graham;Groppi, Vincent E.;Raible, David W.;Rubel, Edwin W.;Simon, Julian A.. And the article was included in Journal of Medicinal Chemistry in 2018.Application of 16413-26-6 This article mentions the following:

Hearing loss is a major public health concern with no pharmaceutical intervention for hearing protection or restoration. Using zebrafish neuromast hair cells, a robust model for mammalian auditory and vestibular hair cells, we identified a urea-thiophene carboxamide, I (ORC-001), as protective against aminoglycoside antibiotic (AGA)-induced hair cell death. The 50% protection (HC50) concentration conferred by I is 3.2 娓璏 with protection against 200 娓璏 neomycin approaching 100%. Compound I was sufficiently safe and drug-like to validate otoprotection in an in vivo rat hearing loss model. We explored the structure-activity relationship (SAR) of this compound series to improve otoprotective potency, improve pharmacokinetic properties and eliminate off-target activity. We present the optimization of I to yield II (ORC-13661). Compound II protects mechanosensory hair cells with HC50 of 120 nM and demonstrates 100% protection in the zebrafish assay and superior physiochem., pharmacokinetic, and toxicol. properties, as well as complete in vivo protection in rats. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Application of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tokala, Ramya et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2018 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C8H4N2O

Synthesis of 1,2,4-triazole-linked urea/thiourea conjugates as cytotoxic and apoptosis inducing agents was written by Tokala, Ramya;Bale, Swarna;Janrao, Ingle Pavan;Vennela, Aluri;Kumar, Niggula Praveen;Senwar, Kishna Ram;Godugu, Chandraiah;Shankaraiah, Nagula. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Formula: C8H4N2O This article mentions the following:

A new series of 1,2,4-triazole-linked urea and thiourea conjugates have been synthesized and evaluated for their in vitro cytotoxicity against selected human cancer cell lines namely, breast (MCF-7, MDA-MB-231), lung (A549) prostate (DU145) and one mouse melanoma (B16-F10) cell line and compared with reference drug. The compound I showed significant cytotoxicity on MCF-7 breast cancer cell line with a IC50 value of 7.22 鍗?0.47 娓璏 among all the tested compounds Notably, induction of apoptosis by compound I on MCF-7 cells was evaluated using different staining techniques such as acridine orange/ethidium bromide (AO/EB), annexin V-FITC/PI, and DAPI. Further, clonogenic assay indicates the inhibition of colony formation on MCF-7 cells by compound I. Moreover, the flow-cytometric anal. also revealed that compound I caused the arrest of cells at G0/G1 phase of cell cycle. In addition, the compounds when tested on normal human cells (L-132) were found to be safer with low cytotoxicity profile. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Formula: C8H4N2O).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C8H4N2O

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Temal, Taoues et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2013 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 16413-26-6

New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas was written by Temal, Taoues;Jary, Helene;Auberval, Marielle;Lively, Sarah;Guedin, Denis;Vevert, Jean-Paul;Deprez, Pierre. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Product Details of 16413-26-6 This article mentions the following:

Starting from Fendiline and R-568, a novel series of urea compounds, e.g. I [R1 = H, i-Bu, t-BuO2CCH2, 2-(4-morpholinyl)ethyl, etc.; R2 = 4-Me, 3-MeO2C, 2-thiazolyl, etc.], was identified as pos. allosteric modulators of the calcium sensing receptor (CaSR), as part of a program to identify novel therapeutics for secondary hyperparathyroidism. Initially identified disubstituted ureas were converted to trisubstituted urea lead I [R1 = 2-(4-morpholinyl)ethyl; R2 = 3-MeO2C], which was further modified to increase in vivo potency. Replacing a carbomethoxy substituent by various bioisosteres led to compound I [R1 = 2-(4-morpholinyl)ethyl; R2 = 5-oxazolyl] which exhibited potent in vitro and in vivo activity after oral administration. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasmussen, C. R. et al. published their research in Journal of Medicinal Chemistry in 1978 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 3-Cyanophenylisocyanate

2-Pyrrolidinylideneureas, a new class of central nervous system agents was written by Rasmussen, C. R.;Gardocki, Joseph F.;Plampin, James N.;Twardzik, Barbara L.;Reynolds, Brian E.;Molinari, Albert J.;Schwartz, Norman;Bennetts, Walter W.;Price, Beth E.;Marakowski, Janis. And the article was included in Journal of Medicinal Chemistry in 1978.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:

Pyrrolidinylideneureas (I) were prepared and screened for pharmacol. activity. I (X = H, 4-NO2, 3-Br, 3-F, 3-Cl, 3-Me) had anxiolytic activity. I 2,6-disubstituted with Me, Cl, and Br imparted potent muscle-relaxant properties which appear to be centrally mediated. A significant separation of the anxiolytic and muscle-relaxant properties fromother CNS activities, eg, anticonvulsant, sedative, and hypnotic, was achieved. I were prepared by treating 2-imino-1-methylpyrrolidines with aryl isocyanates. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Temal, Taoues et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2013 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120掳 C鈥揅鈥揙 and O鈥揅鈥揙 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C鈥揙鈥揅 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 16413-26-6

New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas was written by Temal, Taoues;Jary, Helene;Auberval, Marielle;Lively, Sarah;Guedin, Denis;Vevert, Jean-Paul;Deprez, Pierre. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Product Details of 16413-26-6 This article mentions the following:

Starting from Fendiline and R-568, a novel series of urea compounds, e.g. I [R1 = H, i-Bu, t-BuO2CCH2, 2-(4-morpholinyl)ethyl, etc.; R2 = 4-Me, 3-MeO2C, 2-thiazolyl, etc.], was identified as pos. allosteric modulators of the calcium sensing receptor (CaSR), as part of a program to identify novel therapeutics for secondary hyperparathyroidism. Initially identified disubstituted ureas were converted to trisubstituted urea lead I [R1 = 2-(4-morpholinyl)ethyl; R2 = 3-MeO2C], which was further modified to increase in vivo potency. Replacing a carbomethoxy substituent by various bioisosteres led to compound I [R1 = 2-(4-morpholinyl)ethyl; R2 = 5-oxazolyl] which exhibited potent in vitro and in vivo activity after oral administration. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120掳 C鈥揅鈥揙 and O鈥揅鈥揙 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C鈥揙鈥揅 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasmussen, C. R. et al. published their research in Journal of Medicinal Chemistry in 1978 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 3-Cyanophenylisocyanate

2-Pyrrolidinylideneureas, a new class of central nervous system agents was written by Rasmussen, C. R.;Gardocki, Joseph F.;Plampin, James N.;Twardzik, Barbara L.;Reynolds, Brian E.;Molinari, Albert J.;Schwartz, Norman;Bennetts, Walter W.;Price, Beth E.;Marakowski, Janis. And the article was included in Journal of Medicinal Chemistry in 1978.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:

Pyrrolidinylideneureas (I) were prepared and screened for pharmacol. activity. I (X = H, 4-NO2, 3-Br, 3-F, 3-Cl, 3-Me) had anxiolytic activity. I 2,6-disubstituted with Me, Cl, and Br imparted potent muscle-relaxant properties which appear to be centrally mediated. A significant separation of the anxiolytic and muscle-relaxant properties fromother CNS activities, eg, anticonvulsant, sedative, and hypnotic, was achieved. I were prepared by treating 2-imino-1-methylpyrrolidines with aryl isocyanates. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasmussen, C. R. et al. published their research in Journal of Medicinal Chemistry in 1978 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 3-Cyanophenylisocyanate

2-Pyrrolidinylideneureas, a new class of central nervous system agents was written by Rasmussen, C. R.;Gardocki, Joseph F.;Plampin, James N.;Twardzik, Barbara L.;Reynolds, Brian E.;Molinari, Albert J.;Schwartz, Norman;Bennetts, Walter W.;Price, Beth E.;Marakowski, Janis. And the article was included in Journal of Medicinal Chemistry in 1978.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:

Pyrrolidinylideneureas (I) were prepared and screened for pharmacol. activity. I (X = H, 4-NO2, 3-Br, 3-F, 3-Cl, 3-Me) had anxiolytic activity. I 2,6-disubstituted with Me, Cl, and Br imparted potent muscle-relaxant properties which appear to be centrally mediated. A significant separation of the anxiolytic and muscle-relaxant properties fromother CNS activities, eg, anticonvulsant, sedative, and hypnotic, was achieved. I were prepared by treating 2-imino-1-methylpyrrolidines with aryl isocyanates. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gichinga, MosesG. et al. published their research in ACS Medicinal Chemistry Letters in 2011 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of 3-Cyanophenylisocyanate

Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam was written by Gichinga, MosesG.;Olson, Jeremy P.;Butala, Elizabeth;Navarro, Hernan A.;Gilmour, Brian P.;Mascarella, S. Wayne;Carroll, F. Ivy. And the article was included in ACS Medicinal Chemistry Letters in 2011.Safety of 3-Cyanophenylisocyanate This article mentions the following:

In an effort to discover potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonists, 15 tetrahydropyrimidinone analogs of 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-urea (fenobam) were synthesized. These compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro efficacy assay. The IC50 value for 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-1,4,5,6-tetrahydropyrimidine)urea was essentially identical to that of fenobam. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Safety of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pandey, Garima et al. published their research in RSC Advances in 2015 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 16413-26-6

Microwave-assisted palladium-catalyzed isonitrile insertion in 2-bromophenylureas for efficient synthesis of 4-substituted imino 4H-benzo[d][1,3]oxazin-2-amines was written by Pandey, Garima;Batra, Sanjay. And the article was included in RSC Advances in 2015.Recommanded Product: 16413-26-6 This article mentions the following:

A general route to the synthesis of 4-substituted imino 4H-benzo[d][1,3]oxazin-2-amines via palladium-catalyzed isonitrile insertion in 2-bromophenylureas succeeded by a C-O cross-coupling of the intermediate imidoylpalladium species under microwave irradiation was reported. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics