Category: 15964-79-1

Application of 15964-79-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15964-79-1 as follows.

1-Isopropyl-6,7-dimethoxyisoquinolin-3-ol SIL 32164 To a solution of methyl 2-(3,4-dimethoxyphenyl)acetate SLA 28134 (10.09 g, 48.0 mmol) in isobutyric anhydride (60.5 mL, 364.8 mmol) at 0 C. in a 500 mL round-bottomed flask equipped with a magnetic stirrer was added HClO4 (ca. 70% solution in water, 4.91 mL, 56.8 mmol) over a period of 10 min. The reaction mixture was then allowed to warm up to RT, stirred for 2 h and diluted with Et2O (400 mL). The solid was filtered and washed several times with Et2O to give 16.88 g of a brown solid. The solid was then suspended in H2O (70 mL) in a 500 mL round-bottomed flask equipped with a magnetic stirrer and cooled in an ice bath before dropwise addition of concentrated NH4OH (180 mL). After complete addition, the ice bath was removed and the reaction mixture was stirred overnight at RT. The mixture was then extracted with CH2Cl2 (100 mL, the organic layer was isolated and the aqueous layer was further extracted with CH2Cl2 (3*100 mL). The organic layers were combined, washed with brine (50 mL), dried over Na2SO4, filtered and concentrated under vacuum to give 1-isopropyl-6,7-dimethoxyisoquinolin-3-ol SIL 32164 as a yellow solid (9.69 g, 82% yield). MW: 247.29; Yield: 82%; Yellow solid; Mp ( C.): 175.0 1H-NMR (CDCl3, delta): 1.52 (d, 6H, J=6.9 Hz, 2*CH3), 3.63-3.70 (m, 1H, CH), 3.93 (s, 3H, OCH3), 3.96 (s, 3H, OCH3), 6.57 (s, 1H, ArH), 6.60 (s, 1H, ArH), 6.94 (s, 1H, ArH), OH not seen. 13C-NMR (CDCl3, delta): 21.1 (2*C), 29.4, 55.8, 56.0, 101.8, 102.8, 104.8, 111.8, 142.0, 147.5, 154.5, 154.8, 161.2. MS-ESI m/z (% rel. Int.): 248 ([MH]+, 100).

According to the analysis of related databases, 15964-79-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ExonHit Therapeutics SA; ALLERGAN, INC.; US2012/214837; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

15964-79-1, Adding a certain compound to certain chemical reactions, such as: 15964-79-1, name is Methyl 2-(3,4-dimethoxyphenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15964-79-1.

General procedure: To a mixture corresponding ester (9a-n, 5.0 mmol) and hydrazine monohydrate (15.0 mmol) in ethanol, catalytic amount of pyridine (0.5 mL) was added and refluxed for 10 h. The reaction was monitored by TLC. After the completion of the reaction, ethanol was evaporated from the mixture, water was added and extracted using ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and evaporated under vacuum to get the crude mass. Finally, the products 10a-n were purified using column chromatography. (Yield 80-85%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(3,4-dimethoxyphenyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Manickam, Manoj; Boggu, Pulla Reddy; Pillaiyar, Thanigaimalai; Sharma, Niti; Jalani, Hitesh B.; Venkateswararao, Eeda; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry Letters; vol. 28; 14; (2018); p. 2369 – 2374;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics