Category: 15848-22-3

9/8/21 News Introduction of a new synthetic route about 15848-22-3

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15848-22-3.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15848-22-3, name is 5-Bromopentyl acetate, This compound has unique chemical properties. The synthetic route is as follows., Safety of 5-Bromopentyl acetate

a 5-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)pentyl Acetate A solution of 3-bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol (10 g, 0.35 mol), 5-bromopentyl acetate (8.15 g) and potassium carbonate (33.6 g) in methyl ethyl ketone (200 ml) is refluxed for 2 hours. The reaction medium is treated with water and ethyl acetate. After separation of the phases by settling, the organic phase is washed twice with water, dried over magnesium sulphate and concentrated on a rotary evaporator under vacuum at 40 C. The product is purified by flash chromatography on a column of silica. Yellow oil. Yield: 93%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15848-22-3.

Reference:
Patent; Galderma Research & Development S.N.C.; US6444709; (2002); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A new synthetic route of C7H13BrO2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15848-22-3, name is 5-Bromopentyl acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Bromopentyl acetate

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15848-22-3, name is 5-Bromopentyl acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Bromopentyl acetate

1- (4-METHOXY-PHENYL)-3-TRIFLUOROMETHYL-1, 4,5, 6-tetrahydro- pyrazolo [3,4-c] pyridin-7-one (0.500 g, 1.606 mmol) was dissolved in N, N- DIMETHYLFORMAMIDE (20 mL) and cooled to 0 OC. Sodium hydride (60%, 0.161 g, 4.016 mmol) was added followed by 5-BROMOPENTYL acetate (0.535 mL, 3.213 MMOL). The reaction was stirred at rt overnight, quenched with IN hydrochloric acid (100 mL), EXTRACTED WITH ETHYL ACETATE (3100 ML), WASHED WITH WATER (2X1100 L), washed with brine (1X100 mL), dried over MGSO4, concentrated, and purified by flash CHROMATOGRAPHY USING 0-100% ETHYL ACETATE/HEXANES gradient as the eluent to afford 6- [1- (4-METHOXY-PHENYL)-7-OXO-3-TRIFLUOROMETHYL-1, 4,5, 7-TETRAHYDRO- pyrazolo [3, 4-c] pyridin-6-yl]-hexanoic acid methyl ester (0.699 g, 99%). The ester (0.800 g, 1. 82 mmol) was dissolved in tetrahydrofuran (40 mL), 1M lithium borohydride (3.64 ML, 3.64 mmol) was added, and the reaction was refluxed overnight. The reaction was quenched with water (150 mL), extracted with ethyl acetate (3X150 ML), washed with brine (1X150 mL), dried over MGSO4, concentrated, and purified by flash chromatography using 0-100% ethyl ACETATE/HEXANES as the eluent to afford 0.478 g (64%): 1H NMR (CDCl3) 8 7.44 (d, j=8. 8 Hz, 2H), 6.96 (d, j=9.2 Hz, 2H), 3.84 (s, 3H), 3.67 (t, j=6. 8 Hz, 2H), 3.61 (t, j=6. 4 Hz, 2H), 3.47 (t, j=7. 5 Hz, 2H), 3.00 (t, j=6. 8 Hz, 2H), 1.65-1. 50 (m, 4H), 1.45-1. 30 (m, 4H) ppm.

The synthetic route of 15848-22-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRYSTOL-MYERS SQUIBB COMPANY; WO2004/83177; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Introduction of a new synthetic route about 15848-22-3

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15848-22-3.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15848-22-3, name is 5-Bromopentyl acetate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 15848-22-3

a 5-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)pentyl Acetate A solution of 3-bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol (10 g, 0.35 mol), 5-bromopentyl acetate (8.15 g) and potassium carbonate (33.6 g) in methyl ethyl ketone (200 ml) is refluxed for 2 hours. The reaction medium is treated with water and ethyl acetate. After separation of the phases by settling, the organic phase is washed twice with water, dried over magnesium sulphate and concentrated on a rotary evaporator under vacuum at 40 C. The product is purified by flash chromatography on a column of silica. Yellow oil. Yield: 93%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15848-22-3.

Reference:
Patent; Galderma Research & Development S.N.C.; US6444709; (2002); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics