Category: 15441-07-3

Related Products of 15441-07-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15441-07-3 name is Methyl 3-(chlorosulfonyl)propanoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of Benzyl (25,4a5,6a5,6bR, 8aR, 1OS,1 2a5, 1 2bR, 1 4bR)- 1 O-((3 -methoxy-3 -oxopropyl) sulfonamido)-2,4a,6a,6b,9,9, 12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9, 10,11, 12,12a, 1 2b, 13,1 4b-icosahydropicene-2-carboxylate (72-2). Into a 5 O-mL round-bottom flask, was placed 54-1 (300 mg, 1 equiv.), DCM (10 mL), methyl 3-(chlorosulfonyl)propanoate (200 mg,2.0 equiv.), TEA (0.223 mL). The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with EtOAc/petroleum ether (1:2). This resulted in 326 mg (86%) of 72-2 as a light yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-(chlorosulfonyl)propanoate, and friends who are interested can also refer to it.

Reference:
Patent; ARDELYX, INC.; LUEHR, Gary; DRAGOLI, Dean; LEADBETTER, Michael; CHEN, Tao; LEWIS, Jason; (181 pag.)WO2019/60051; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H7ClO4S

A solution of aniline (0.490 mL, 5.369 mmol) and pyridine (0.520 mL, 6.443 mmol) in dichloromethane (10 mL) was mixed at the room temperature with methyl 3-(chlorosulfonyl)propanoate (1.102 g, 5.906 mmol). The reaction mixture was stirred at the same temperature for 12 hr. Then, water was added to the reaction mixture, followed by extraction with dichloromethane. The organic layer was washed with aqueous 0. iN-hydrochloric acid solution, dried with anhydrous Mg504, filtered, and concentrated in vacuo. The title compound was used without further purification (methyl 3-(N-phenylsulfamoyl)propanoate, 1.000 g, 71.3 %, brown solid).

According to the analysis of related databases, 15441-07-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; CHOI, Daekyu; MIN, Jaeki; BAE, Miseon; YANG, Hyunmo; KIM, Dohoon; (644 pag.)WO2017/18803; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C4H7ClO4S

7V-(3-Methyl-benzo[Z>]thiophen-2-yl)-2-carbomethoxy-ethanesulfonamide (600-A).; A solution of compound 757-A (1.0 g, 5.01 mmol) and pyridine (851 muL, 10.5 mmol) in dichloromethane (20 mL), cooled to 10 0C was treated with 3- chlorosulfonyl-propionic acid methyl ester (716 muL, 5.25 mmol) and stirred at ambient temperature for 18 h. The solvent was evaporated in vacuo, and the crude residue purified by flash column chromatography (SiO2), eluting with an ethyl acetate (10- 50%) in heptane gradient to afford 1.1 g of compound 600-A as an off white solid. 1H- NMR (DMSO-fe): delta 2.31 (s, 3H), 2.82 (t, 2H), 3.43 (t, 2H), 3.62 (s, 3H), 7.24-7.50 (m, 2H), 7.58-7.77 (m, IH), 7.80-7.95 (m, IH), 10.17 (s, IH); MS: m/z 314.1 (MH+).

The synthetic route of 15441-07-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2009/12430; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 15441-07-3, The chemical industry reduces the impact on the environment during synthesis 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate, I believe this compound will play a more active role in future production and life.

d Methyl 3-[2-(2-phenylthioethoxy)ethylaminosulphonyl]propanoate The subtitle compound (2.85 g) was prepared according to the procedure in example 5 part d using 2-(2-phenylthioethoxy)ethanamine hydrochloride (6 g), triethylamine (4 ml) methyl 3-(chlorosulphonyl)propanoate (5.8 g), and dichloromethane (50 ml). Mass spectrum FAB 348 (M+105).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-(chlorosulfonyl)propanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Astra Pharmaceuticals Limited; US5846989; (1998); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 15441-07-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[0586] Preparation of 53 [0587] To a solution of 52 (0.08 g, 0.395 mmol) in CH2Cl2 (3 mL), added pyridine (74 muL) and methyl 3-(chlorosulfonyl)propanoate (0.1 g, 0.544 mmol). Reaction mixture was stirred for 16 h at rt. and then poured in 10% HCl solution followed by extraction with CH2Cl2. Organic layer was dried and evaporated to obtained 53 (52mg, 34%).

The synthetic route of Methyl 3-(chlorosulfonyl)propanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cambridge Enterprise Limited; Kapadnis, Prashant Bhimrao; Glen, Robert; Hiley, Robin; Bell, James; Spring, David; US2013/53372; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 15441-07-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a 100 mL round bottom flask, to a solution of methyl 3-(chlorosulfonyl)propanoate (187 mg, 1 mmol) and S-trans, trans-farnesyl-L-cysteine methyl ester (339 mg, 1 mmol) in THF (5 mL) was added N,N-diisopropyl-ethyl-amine (0.52 mL, 3 mmol) dropwise. The solution was stirred at 0 0C for 30 min and then room temperature overnight. The mixture was diluted with ethyl acetate (60 mL) and washed by 0.5 N HCl (10 mL x 1), H2O (10 mL x 1) and brine (10 mL x 1). The organic layer was dried over Na2SO4 and concentrated in vacuo. The resulting residue was dissolved in THF (3 rnL) and a solution Of LiOH-H2O (420 mg, 10 mmol) in H2O (2 mL) was added slowly at 0 0C. The reaction was left at room temperature overnight. The solution was then diluted with ethyl acetate and washed by 0.5 N HCl (10 mL x 1), H2O (10 mL x 2) and brine (15 mL x 1). The organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was then further purified by preparative HPLC (100 mg, 22%) to yield Compound N-80. 1H-NMR (500 MHz, CD3OD): delta 1.50 (s, 3H), 1.51 (s, 3H), 1.57 (s, 3H), 1.61 (s, 3H), 1.86-1.89 (m, 2H), 1.95-2.00 (m, 4H), 2.01-2.06 (m, 4H), 2.65 (dd, J = 8.0, 14.0 Hz, IH), 2.71-2.76 (m, 2H), 2.84 (dd, J = 5.0, 14.0 Hz, IH), 3.13 (dd, J = 7.5, 13.5 Hz, IH), 3.24-3.29 (m, IH), 4.05 (dd, J = 5.0, 8.0 Hz, IH), 4.98-5.03 (m, 2H), 5.09-5.14 (t, J = 8.0 Hz, IH). 13C-NMR (125 MHz, CD3OD): delta 16.15, 16.30, 17.80, 25.95, 27.38, 27.79, 29.56, 30.44, 34.80, 40.78, 40.89, 49.82, 57.51, 121.64, 125.16, 125.46, 132.12, 136.27, 140.62, 174.04, 174.15; ES-MS: mass calcd for Chemical Formula: C21H35NO6S2 461.64. Found (M+) m/z 462.2, (M+Na) m/z 484.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-(chlorosulfonyl)propanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SIGNUM BIOSCIENCES, INC.; STOCK, Jeffry, B.; STOCK, Maxwell; RAPOLE, Keshava; LEE, Seung-yub; VORONKOV, Michael; PEREZ, Eduardo; CHEN, Shuyi; CHEN, Jinglong; GORDON, Joel; WO2010/56778; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 15441-07-3, These common heterocyclic compound, 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of Compound IE (40 mg, 0.092 mmol) and triethylamine (0.026 mL, 0.184 mmol) in CH2CI2 (1 mL) in an ice bath was added methyl 3- (chlorosulfonyl)propanoate (25.7 mg, 0.138 mmol). Upon completion of addition, the reaction mixture was stirred in the ice bath for 15 min. After this time, the reaction mixture was allowed to warm to rt, where it stirred for 3 h. At the conclusion of this period, the reaction mixture was quenched with saturated aq aHCOs (1 mL) and then extracted with CH2CI2 (3 x 2 mL). The combined organic layers were dried( a2S04), filtered, and concentrated to yield a residue. The residue was purified by column chromatography (silica gel, CELC^-EtOAc gradient 0 to 90% EtOAc) to afford Example 2 as a white solid (42 mg, 78% yield). XH NMR (500 MHz, DMSO- d6) delta ppm 8.24 (2H, s), 7.98 (IH, d, J=1.9 Hz), 7.64 (IH, d, J=8.5 Hz), 7.51 (IH, dd, J=8.5, 1.9 Hz), 6.20 – 6.26 (IH, m), 5.36 – 5.44 (IH, m), 4.15 – 4.23 (2H, m), 3.91 – 3.95 (2H, m), 3.62 (3H, s), 3.51 – 3.59 (2H, m), 3.46 (2H, t, J=5.6 Hz), 3.40 (2H, t, J=7.2 Hz), 2.74 (2H, t, J=7.2 Hz), 2.57 – 2.66 (2H, m), 2.38 (2H, t, J=7.4 Hz), 2.09 – 2.19 (2H, m), 1.70 – 1.81 (2H, m), 1.47 – 1.58 (2H, m), 0.88 (3H, t, J=7.3 Hz).LC/MS (m/z) = 586 (M+H)+.

The synthetic route of 15441-07-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YE, Xiang-Yang; WACKER, Dean A.; ROBL, Jeffrey A.; WANG, Ying; WO2011/140160; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 15441-07-3,Some common heterocyclic compound, 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate, molecular formula is C4H7ClO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 14 N-isobutyl-3-amidosulfopropionic Acid To 14.6 parts of isobutylamine and 100 parts of water there are added dropwise at 0 C, with stirring 18.65 parts of methyl 3-chlorosulfonylpropionate and then simultaneously from separate dropping funnels 18.65 parts of methyl 3-chlorosulfonylpropionate and 54 parts of 14.8% caustic soda solution. Stirring is continued for a further hour at 0 C and 4 hours at room temperature; 8.8 parts of sodium hydroxide are added and the mixture is heated at 60 C for 4 hours. The reaction mixture is acidified with a 2N H2 SO4 solution to a pH of 1 and the resulting precipitate is filtered off, washed with 100 parts of water and dried at 40 C/25 mm. Yield: 24.6 parts (59% of theory) of white crystalline N-isobutyl-3-amidosulfopropionic acid, m.p. 132-134 C (after recrystallization from H2 O).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-(chlorosulfonyl)propanoate, its application will become more common.

Reference:
Patent; BASF Aktiengesellschaft; US4060522; (1977); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 15441-07-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-isopropyl-5-(4-(6-(l,2,3,6-tetrahydropyridin-4- yl)benzo[d]thiazol-2-yloxy)piperidin-l-yl)-l,2,4-oxadiazole (Compound 43E, 95 mg, 0.223 mmol) and triethylamine (0.08 mL, 0.56 mmol) in CH2C12 (2mL) at 0 C was added methyl 3-(chlorosulfonyl)propanoate (62.5 mg, 0.335 mmol). The reaction mixture was stirred at 0 C for 15 min, then at rt overnight. The reaction mixture was quenched with sat. aq. aHC03 (2 mL) and extracted with CH2CI2 (3 x 3 mL). The combined organic layers were dried ( a2S04), filtered, and concentrated. The residue was purified by column chromatography (silica gel, CH2Cl2-EtOAc gradient 0 to 60% EtOAc) to afford methyl 3-(4-(2-(l-(3-isopropyl-l,2,4-oxadiazol-5-yl)piperidin-4- yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-l(2H)-ylsulfonyl)propanoate (75 mg, 0.13 mmol, 58% yield) as an off white solid. LCMS (m/z) =576 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis Methyl 3-(chlorosulfonyl)propanoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YE, Xiang-Yang; WACKER, Dean A.; ROBL, Jeffrey A.; WANG, Ying; WO2011/140160; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics