Category: 153034-91-4

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 153034-91-4, is researched, Molecular C5H2ClI2N, about Iterative and regioselective cross-couplings of 2-chloro-3,4-diiodopyridine leading to 2,3,4-triheteroarylpyridines, the main research direction is chloropyridine ortho metalation halogen dance; chlorodiiodopyridine preparation aryl boronic regioselective Suzuki Miyaura cross coupling; triheteroarylpyridine preparation; heteroaryl chloro iodopyridine preparation; chloro diheteroarylpyridine preparation; bis phenylethynylpyridinyl fluoropyridine preparation.Formula: C5H2ClI2N.

A one-pot synthesis of 2-chloro-3,4-diiodopyridine from 2-chloropyridine is described via a directed ortho metalation (DoM)/halogen dance (HD) mechanism in 26-28% yields. By performing sequential, iterative Suzuki-Miyaura cross-couplings using a variety of functionalized heteroaryl and arylboronic acids, a series of novel 2,3,4-triheteroarylpyridine scaffolds have been accessed in synthetically viable yields, including sterically hindered derivatives. 2-Chloro-4-heteroaryl-3-iodopyridines and 2-chloro-3,4-diheteroarylpyridines are also synthesized. The synthesis of 5-[3,4-bis(2-phenylethynyl)pyridin-2-yl]-2-fluoropyridine via a two-step Sonogashira/Suzuki-Miyaura reaction sequence from 2-chloro-3,4-diiodopyridine, phenylacetylene and 6-fluoropyridin-3-yl-3-boronic acid has been achieved in 48% overall yield.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloro-3,4-diiodopyridine, is researched, Molecular C5H2ClI2N, CAS is 153034-91-4, about First metalation of aryl iodides: directed ortho-lithiation of iodopyridines, halogen-dance, and application to synthesis.Safety of 2-Chloro-3,4-diiodopyridine.

Metalation of iodopyridines was successfully achieved by LDA at low temperature In many cases, lithiation is ortho directed by the iodo group which subsequently ortho-migrates very fast to give stabilized iodolithiopyridines. This procedure was applied to 2-fluoro- and 2-chloro-3-iodopyridines, 3-fluoro-4-iodopyridine, and 2-chloro-3-fluoro-4-iodopyridine. The resulting lithio intermediates were obtained in high yields before being reacted with electrophiles leading to various polysubstituted pyridines. Some of these iodopyridines were used as key mols. for the preparation of fused polyaromatic alkaloids. Thus, perlolidine (I), δ-carbolines, and 2,10-diazaphenanthrenes were readily prepared in few steps taking advantage of the iodo reactivity for heteroring cross-coupling. Coupling of [2-(pivaloylamino)phenyl]boronic acid with 2-fluoro-4-iodo-3-pyridinecarboxaldehyde gave I.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-3,4-diiodopyridine(SMILESS: IC1=C(I)C(Cl)=NC=C1,cas:153034-91-4) is researched.Application of 4774-24-7. The article 《Palladium-catalysed aminocarbonylation of diiodopyridines》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:153034-91-4).

The aminocarbonylation of 2,5- and 2,3-diiodopyridine, as well as 2-chloro-3,4-diiodopyridine with carbon monoxide and primary and secondary amines was carried out using palladium-catalyzed aminocarbonylation. Formation of the products containing imidopyridine, carboxamide and ketocarboxamide functionalities was accompanied by the formation of imides when ortho-diiodo compounds were used as substrates. In spite of several possible reaction pathways, most of the products were synthesized as major product in yields of synthetic interest by appropriate modification in the reaction conditions.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics