Okayama, Toru’s team published research in Organic Letters in 2000 | CAS: 152942-06-8

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate

Okayama, Toru; Burritt, Andrew; Hruby, Victor J. published an article in Organic Letters. The title of the article was 《4-Alkoxy-2-hydroxybenzaldehyde (AHB): A Versatile Aldehyde Linker for Solid-Phase Synthesis of C-Terminal Modified Peptides and Peptidomimetics》.Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate The author mentioned the following in the article:

A new and versatile 4-alkoxy-2-hydroxybenzaldehyde (AHB) linker for solid-phase syntheses is described. Acylation of the polymer-bound secondary amine obtained from reductive amination of the aldehyde in the AHB linker showed good reactivity. Following acylation of the phenolic OH group, the resulting carboxamide resin was stable to treatment with 95% CF3CO2H (TFA). The O-acyl functional group was removed with 20% piperidine, and the desired compound was cleaved from the resin by TFA treatment. In the experimental materials used by the author, we found Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate)

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adusumalli, Srinivasa Rao’s team published research in Organic & Biomolecular Chemistry in 2018 | CAS: 152942-06-8

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Quality Control of Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

The author of 《Aldehydes can switch the chemoselectivity of electrophiles in protein labeling》 were Adusumalli, Srinivasa Rao; Rawale, Dattatraya Gautam; Rai, Vishal. And the article was published in Organic & Biomolecular Chemistry in 2018. Quality Control of Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate The author mentioned the following in the article:

We show that the chemoselectivity of an electrophile in protein labeling can be promiscuous. An aldehyde enables switching of chemoselectivity of an epoxide and a sulfonate ester along with an enhanced rate of reaction. The chem. technol. renders single-site installation of diverse probes on a protein and delivers anal. pure tagged proteins. After reading the article, we found that the author used Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8Quality Control of Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate)

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Quality Control of Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thomas, Michael G.’s team published research in Bioorganic & Medicinal Chemistry Letters in 2003 | CAS: 152942-06-8

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Category: esters-buliding-blocks Polyesters are important plastics, with monomers linked by ester moieties.

Thomas, Michael G.; Lawson, Chris; Allanson, Nigel M.; Leslie, Bruce W.; Bottomley, Joanna R.; McBride, Andrew; Olusanya, Oyinkan A. published an article on February 10 ,2003. The article was titled 《A series of 2(Z)-2-Benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones as inhibitors of chorismate synthase》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Category: esters-buliding-blocks The information in the text is summarized as follows:

A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones was identified as potent inhibitors of bacterial chorismate synthase. The 2′-hydroxy-4′-pentoxy analog 33 is a potent inhibitor of Streptococcus pneumoniae chorismate synthase. In the experimental materials used by the author, we found Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8Category: esters-buliding-blocks)

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Category: esters-buliding-blocks Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adusumalli, Srinivasa Rao’s team published research in Angewandte Chemie, International Edition in 2020 | CAS: 152942-06-8

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters.COA of Formula: C13H16O5 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Adusumalli, Srinivasa Rao; Rawale, Dattatraya Gautam; Thakur, Kalyani; Purushottam, Landa; Reddy, Neelesh C.; Kalra, Neetu; Shukla, Sanjeev; Rai, Vishal published an article in Angewandte Chemie, International Edition. The title of the article was 《Chemoselective and Site-Selective Lysine-Directed Lysine Modification Enables Single-Site Labeling of Native Proteins》.COA of Formula: C13H16O5 The author mentioned the following in the article:

The necessity for precision labeling of proteins emerged during the efforts to understand and regulate their structure and function. It demands selective attachment of tags such as affinity probes, fluorophores, and potent cytotoxins. Here, the authors report a method that enables single-site labeling of a high-frequency Lys residue in the native proteins. At first, the enabling reagent forms stabilized imines with multiple solvent-accessible Lys residues chemoselectively. These linchpins create the opportunity to regulate the position of a second Lys-selective electrophile connected by a spacer. Consequently, it enables the irreversible single-site labeling of a Lys residue independent of its place in the reactivity order. The user-friendly protocol involves a series of steps to deconvolute and address chemoselectivity, site-selectivity, and modularity. Also, it delivers ordered immobilization and anal. pure probe-tagged proteins. Besides, the methodol. provides access to antibody-drug conjugate (ADC), which exhibits highly selective anti-proliferative activity towards HER-2 expressing SKBR-3 breast cancer cells. After reading the article, we found that the author used Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8COA of Formula: C13H16O5)

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters.COA of Formula: C13H16O5 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adusumalli, Srinivasa Rao’s team published research in Journal of the American Chemical Society in 2018 | CAS: 152942-06-8

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Product Details of 152942-06-8 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Product Details of 152942-06-8On November 7, 2018 ,《Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology》 appeared in Journal of the American Chemical Society. The author of the article were Adusumalli, Srinivasa Rao; Rawale, Dattatraya Gautam; Singh, Usha; Tripathi, Prabhanshu; Paul, Rajesh; Kalra, Neetu; Mishra, Ram Kumar; Shukla, Sanjeev; Rai, Vishal. The article conveys some information:

Chem. biol. research often requires precise covalent attachment of labels to the native proteins. Such methods are sought after to probe, design, and regulate the properties of proteins. At present, this demand is largely unmet due to the lack of empowering chem. technol. Here, we report a chem. platform that enables site-selective labeling of native proteins. Initially, a reversible intermol. reaction places the “”chem. linchpins”” globally on all the accessible Lys residues. These linchpins have the capability to drive site-selective covalent labeling of proteins. The linchpin detaches within physiol. conditions and capacitates the late-stage installation of various tags. The chem. platform is modular, and the reagent design regulates the site of modification. The linchpin is a multitasking group and facilitates purification of the labeled protein eliminating the requirement of addnl. chromatog. tag. The methodol. allows the labeling of a single protein in a mixture of proteins. The precise modification of an accessible residue in protein ensures that their structure remains unaltered. The enzymic activity of myoglobin, cytochrome C, aldolase, and lysozyme C remains conserved after labeling. Also, the cellular uptake of modified insulin and its downstream signaling process remain unperturbed. The linchpin directed modification (LDM) provides a convenient route for the conjugation of a fluorophore and drug to a Fab and monoclonal antibody. It delivers trastuzumab-doxorubicin and trastuzumab-emtansine conjugates with selective antiproliferative activity toward Her-2 pos. SKBR-3 breast cancer cells. In the experimental materials used by the author, we found Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8Product Details of 152942-06-8)

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Product Details of 152942-06-8 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics