Synthesis and preliminary data on new selective and potent gastric prokinetic substituted benzamides was written by Del Corona, L.;Signorelli, G.;Pinzetta, A.;Coppi, G.. And the article was included in European Journal of Medicinal Chemistry in 1993.Application In Synthesis of Methyl 5-amino-4-fluoro-2-methoxybenzoate The following contents are mentioned in the article:
A series of amino-halogen-N-[2-aminoethyl] benzamides, e.g., I, was synthesized and evaluated for enhancing gastric emptying. Compared to metoclopramide, domperidone and bromopride, a number of compounds were more active in enhancing gastric motility (rat stomach emptying), devoid of dopaminergic D2-receptor antagonism (rat apomorphine test) and were less toxic. This study involved multiple reactions and reactants, such as Methyl 5-amino-4-fluoro-2-methoxybenzoate (cas: 151793-18-9Application In Synthesis of Methyl 5-amino-4-fluoro-2-methoxybenzoate).
Methyl 5-amino-4-fluoro-2-methoxybenzoate (cas: 151793-18-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of Methyl 5-amino-4-fluoro-2-methoxybenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics