Category: 151259-38-0

Breen, Christopher P.; Parrish, Christine; Shangguan, Ning; Majumdar, Sudip; Murnen, Hannah; Jamison, Timothy F.; Bio, Matthew M. published the artcile< A Scalable Membrane Pervaporation Approach for Continuous Flow Olefin Metathesis>, Formula: C11H19NO2, the main research area is scalable membrane pervaporation olefin metathesis.

The translation of olefin metathesis reactions from the laboratory to process scale has been challenging with traditional batch techniques. In this contribution, we describe a continuous membrane reactor design that selectively permeates the ethylene byproduct from metathetical processes, thereby overcoming the mass-transport limitations that have neg. influenced the efficiency of this transformation in batch vessels. The membrane sheet-in-frame pervaporation module yielded turnover numbers of >7500 in the case of di-Et diallylmalonate ring-closing metathesis. The preparation of more challenging, low-effective-molarity substrates, a cyclooctene and a 14-membered macrocyclic lactone, was also effective. A comparison of optimal membrane reactor conditions to a sealed tubular reactor revealed that the benefits of ethylene removal are most apparent at low reaction concentrations

Organic Process Research & Development published new progress about Flow. 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Formula: C11H19NO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Ziwei; Tsui, Gavin Chit published the artcile< Radical cyclization/bis(pentafluoroethylation) of 1,6-dienes using HCF2CF3-derived CuCF2CF3>, Application of C11H19NO2, the main research area is pyrrolidine pentafluoropropyl preparation diastereoselective; diallylamine copper pentafluoroethyl radical cyclization pentafluoroethylation; pentafluoropropyl cyclopentane preparation diastereoselective; diallyl malonate copper pentafluoroethyl radical cyclization pentafluoroethylation.

A domino radical cyclization/bis(pentafluoroethylation) of 1,6-dienes CH2=CHCH2N(R)CH2C(=CH2)R1 (R = H, 4-H3CC6H4SO2, 2,6-bis(propan-2-yl)phenyl, CH2CH=CH2, etc.; R1 = H, Me), and CH2=CHCH2C(R2)(R3)CH2CH=CH2 [R2 = R3 = C(O)OEt, C(O)OPh, C(O)Bn, etc. R2R3 = -C(O)(CH2)3C(O)-] for the synthesis of new classes of pyrrolidine I and cyclopentane derivatives II containing two C2F5 groups was described. This reaction is efficient for constructing three carbon-carbon bonds in one step. The reagent [CuCF2CF3] is prepared from inexpensive pentafluoroethane and the reactions conveniently run at room temperature in open air. Moderate to good diastereoselectivities can be obtained favoring the cis products I with X-ray structural proof.

Organic Chemistry Frontiers published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Application of C11H19NO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gravatt, Christopher S.; Melecio-Zambrano, Luis; Yoon, Tehshik P. published the artcile< Olefin-Supported Cationic Copper Catalysts for Photochemical Synthesis of Structurally Complex Cyclobutanes>, SDS of cas: 151259-38-0, the main research area is alkene aliphatic copper photochem Salomon Kochi reaction catalyst; cyclobutane stereoselective preparation; alkene ligands; copper; cycloaddition; photocatalysis; small-ring compounds.

The sole method available for the photocycloaddition of unconjugated aliphatic alkenes is the Cu-catalyzed Salomon-Kochi reaction. The [Cu(OTf)]2·benzene catalyst that has been standard in this reaction for many decades, however, is air-sensitive, prone to photodecomposition, and poorly reactive towards sterically bulky alkene substrates. Using bench-stable precursors, an improved catalyst system with superior reactivity and photostability has been designed, and it offers significantly expanded substrate scope. The utility of this new catalyst for the preparation of sterically crowded cyclobutane structures is highlighted through the preparation of the cores of the natural products sulcatine G and perforatol.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, SDS of cas: 151259-38-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shetgaonkar, Abhijit D.; Nadkarni, Vishnu S. published the artcile< Synthetically Induced 1→4-C Branching Motif - An Access Towards Dense Urethane Connecting Dendritic Scaffolds and Application in Nuclear Track Detection>, Safety of tert-Butyl diallylcarbamate, the main research area is urethane connecting polyoleifinic dendrimer preparation nuclear track detection.

A series of dumbbell-shaped urethane connecting polyoleifinic dendrimers, are synthesized from com. AB2 monomer through the concept of post-generative synthetic induction of novel 1→4-C branching motif in divergent and convergent growth methodol. using carbamoyl chloride reactivity. A synthetic protocol is conducted through the iterative process of O-carbamoyl-allylation of hydroxyls followed by Upjohn dihydroxylation of the allylic double bonds, leading to protection/deprotection free divergent pathway. In parallel, convergent growth route gains dendrimers in relatively good yields. Also, the process of O-carbonyloxy-allylation of [G-1] polyol affords urethane-carbonate framework providing access to 1→2-C branching further. Incorporation of current branching motif results in dendritic scaffold with dense periphery at lower generations itself. Free radical cast polymerization of [G-0.5] dendrimer with allyl diglycol carbonate (ADC) produces thermoset polymer films, showing good sensitivity and ability to permanently record nuclear tracks.

ChemistrySelect published new progress about Dendrimers Role: SPN (Synthetic Preparation), PREP (Preparation). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Safety of tert-Butyl diallylcarbamate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shu, Wei; Garcia-Dominguez, Andres; Quiros, M. Teresa; Mondal, Rahul; Cardenas, Diego J.; Nevado, Cristina published the artcile< Ni-Catalyzed Reductive Dicarbofunctionalization of Nonactivated Alkenes: Scope and Mechanistic Insights>, Quality Control of 151259-38-0, the main research area is nickel catalyzed reductive carbofunctionalization alkene scope mechanism.

Olefins devoid of directing or activating groups have been dicarbofunctionalized here with two electrophilic carbon sources under reductive conditions. Simultaneous formation of one C(sp3)-C(sp3) and one C(sp3)-C(sp2) bond across a variety of unbiased π-systems proceeds with exquisite selectivity by the combination of a Ni catalyst with TDAE as sacrificial reductant. Control experiments and computational studies revealed the feasibility of a radical-based mechanism involving, formally, two interconnected Ni(I)/Ni(III) processes and demonstrated the different ability of Ni(I) species (Ni(I)I vs PhNi(I)) to reduce the C(sp3)-I bond. The role of the reductant was also investigated in depth, suggesting that a one-electron reduction of Ni(II) species to Ni(I) is thermodynamically favored. Further, the preferential activation of alkyl vs aryl halides by ArNi(I) complexes as well as the high affinity of ArNi(II) for secondary over tertiary C-centered radicals explains the lack of undesired homo- and direct coupling products (Ar-Ar, Ar-Alk) in these transformations.

Journal of the American Chemical Society published new progress about Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Quality Control of 151259-38-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fang, Jie; Hu, Qiang; Dong, Wan-Li; Xu, Guo-Qiang; Hu, Xiu-Qin; Luo, Yong-Chun; Xu, Peng-Fei published the artcile< Photoredox-catalyzed hydrocarboxymethylation of alkenes>, Electric Literature of 151259-38-0, the main research area is alkene photoredox catalyzed hydrocarboxymethylation.

Direct introduction of a carboxyl group into mols. is one of the most useful methods for the preparation of carboxylic acids, which avoids the conversion of various preexisting functional groups and features good step- and atom-economy. However, the methods for the direct synthesis of two-carbon added carboxylic acids from the precursors remain rare. Herein, we first report a general and mild method for the direct synthesis of a range of aliphatic acids by photoredox-catalyzed hydrocarboxymethylation of alkenes with good toleration of various functional groups in which bromoacetic acid is utilized as an ideal two-carbon synthon. The synthetic utility of this hydrocarboxymethylation protocol is further demonstrated by the concise synthesis of two marketed drugs, sensipar and tirofiban, from com. available starting materials.

CCS Chemistry published new progress about Alkenes Role: TEM (Technical or Engineered Material Use), USES (Uses). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Electric Literature of 151259-38-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Lei; Lee, Wes; Youshaw, Cassandra R.; Yuan, Mingbin; Geherty, Michael B.; Zavalij, Peter Y.; Gutierrez, Osvaldo published the artcile< Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents>, Category: esters-buliding-blocks, the main research area is alkylarylated compound chemoselective regioselective diastereoselective preparation; alkene alkylhalide Grignard reagent three component dicarbofunctionalization iron catalyst.

A highly chemoselective iron-catalyzed three-component dicarbofunctionalization of unactivated olefins with alkyl halides (iodides and bromides) and sp2-hybridized Grignard reagents was reported. The reaction operates under fast turnover frequency and tolerated a diverse range of sp2-hybridized nucleophiles, alkyl halides and unactivated olefins to yield the desired 1,2-alkylarylated products R1R2R3CCH2CHRCH2alkyl [R = Ph, 4-MePH, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Me, Et; R3 = Me, Et, (CH2)2Ph, etc.; alkyl = n-hexyl, (CH2)2CH:CH, (CH2)2Ph, etc.] with high regiocontrol. Further, this protocol was amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines such as I [Ar = 3-MeOPh, 2-MePH, 3-thienyl, etc.; X = O] via a three-component radical cascade cyclization/arylation that forges three new C-C bonds was also demonstrated.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Lei; Lee, Wes; Youshaw, Cassandra R.; Yuan, Mingbin; Geherty, Michael B.; Zavalij, Peter Y.; Gutierrez, Osvaldo published the artcile< Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents>, Category: esters-buliding-blocks, the main research area is alkylarylated compound chemoselective regioselective diastereoselective preparation; alkene alkylhalide Grignard reagent three component dicarbofunctionalization iron catalyst.

A highly chemoselective iron-catalyzed three-component dicarbofunctionalization of unactivated olefins with alkyl halides (iodides and bromides) and sp2-hybridized Grignard reagents was reported. The reaction operates under fast turnover frequency and tolerated a diverse range of sp2-hybridized nucleophiles, alkyl halides and unactivated olefins to yield the desired 1,2-alkylarylated products R1R2R3CCH2CHRCH2alkyl [R = Ph, 4-MePH, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Me, Et; R3 = Me, Et, (CH2)2Ph, etc.; alkyl = n-hexyl, (CH2)2CH:CH, (CH2)2Ph, etc.] with high regiocontrol. Further, this protocol was amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines such as I [Ar = 3-MeOPh, 2-MePH, 3-thienyl, etc.; X = O] via a three-component radical cascade cyclization/arylation that forges three new C-C bonds was also demonstrated.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Lei; Lee, Wes; Youshaw, Cassandra R.; Yuan, Mingbin; Geherty, Michael B.; Zavalij, Peter Y.; Gutierrez, Osvaldo published the artcile< Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents>, Category: esters-buliding-blocks, the main research area is alkylarylated compound chemoselective regioselective diastereoselective preparation; alkene alkylhalide Grignard reagent three component dicarbofunctionalization iron catalyst.

A highly chemoselective iron-catalyzed three-component dicarbofunctionalization of unactivated olefins with alkyl halides (iodides and bromides) and sp2-hybridized Grignard reagents was reported. The reaction operates under fast turnover frequency and tolerated a diverse range of sp2-hybridized nucleophiles, alkyl halides and unactivated olefins to yield the desired 1,2-alkylarylated products R1R2R3CCH2CHRCH2alkyl [R = Ph, 4-MePH, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Me, Et; R3 = Me, Et, (CH2)2Ph, etc.; alkyl = n-hexyl, (CH2)2CH:CH, (CH2)2Ph, etc.] with high regiocontrol. Further, this protocol was amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines such as I [Ar = 3-MeOPh, 2-MePH, 3-thienyl, etc.; X = O] via a three-component radical cascade cyclization/arylation that forges three new C-C bonds was also demonstrated.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Lei; Lee, Wes; Youshaw, Cassandra R.; Yuan, Mingbin; Geherty, Michael B.; Zavalij, Peter Y.; Gutierrez, Osvaldo published the artcile< Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents>, Category: esters-buliding-blocks, the main research area is alkylarylated compound chemoselective regioselective diastereoselective preparation; alkene alkylhalide Grignard reagent three component dicarbofunctionalization iron catalyst.

A highly chemoselective iron-catalyzed three-component dicarbofunctionalization of unactivated olefins with alkyl halides (iodides and bromides) and sp2-hybridized Grignard reagents was reported. The reaction operates under fast turnover frequency and tolerated a diverse range of sp2-hybridized nucleophiles, alkyl halides and unactivated olefins to yield the desired 1,2-alkylarylated products R1R2R3CCH2CHRCH2alkyl [R = Ph, 4-MePH, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Me, Et; R3 = Me, Et, (CH2)2Ph, etc.; alkyl = n-hexyl, (CH2)2CH:CH, (CH2)2Ph, etc.] with high regiocontrol. Further, this protocol was amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines such as I [Ar = 3-MeOPh, 2-MePH, 3-thienyl, etc.; X = O] via a three-component radical cascade cyclization/arylation that forges three new C-C bonds was also demonstrated.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics