Category: 150726-89-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 150726-89-9, name is Dimethyl 2-(2-methoxyphenoxy)malonate, This compound has unique chemical properties. The synthetic route is as follows., name: Dimethyl 2-(2-methoxyphenoxy)malonate

a) At 5 C. 12.7 g of sodium methylate was added portionwise to a solution of 18.9 g of dimethyl-2-(o-methoxyphenoxy)malonate in 450 ml of methanol. Upon completion of the addition stirring was continued at room temperature for 30 min followed by the addition of 6 g of formamidine hydrochloride. The mixture was stirred at room temperature for 72 h. Eventually, the solvent was removed under reduced pressure and the remaining residue was suspended in diethyl ether. The solid material was filtered off and dissolved in 100 ml of water. The solution was acidified with conc. hydrochloric acid. A white precipitate formed. The precipitate was collected, washed with water and dried to give 15.1 g of 5-(o-methoxyphenoxy)-4,6-dihydroxy-pyrimidine (or a tautomer) as a white powder.

According to the analysis of related databases, 150726-89-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Actelio Pharmaceuticals Ltd.; US6596719; (2003); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 150726-89-9, name is Dimethyl 2-(2-methoxyphenoxy)malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 150726-89-9

Preparation 2 5-(2-Methoxyphenoxy)-2-(3-pyridazinyl)-4,6-pyrimidinediol Dimethyl 2-(2-methoxyphenoxy)malonate (3.05 g, 12.6 mmol) (Ref. Canadian Patent Application No. CA2071193A, 1992) in methanol (15 ml) was added over 5 minutes to a stirred, 25% w/v solution of sodium methoxide in methanol (8.58 ml, 37.8 mmol of sodium methoxide) at room temperature. The resulting mixture was stirred for 10 minutes and then a solution of 3-pyridazinecarboximidamide hydrochloride (2.0 g, 12.6 mmol) in methanol (15 ml) was added dropwise over 5 minutes and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and then diluted with water (100 ml). The aqueous solution was acidified to pH 4 with sulfuric acid (20%), resulting in the formation of the title compound as a purple solid, which was isolated by filtration (1.4 g). 1H-NMR (300 MHz, DMSO-d6): 3.83 (s, 3H), 6.68 (d, 1H), 6.78 (t, 1H), 6.93 (t,1H), 7.03 (d,1H), 7.94 (dd,1H), 8.34 (d,1H), 9.43 (d,1H) ppm. HRMS (+ve ion) found: m/z 313.0929 (MH+). C15H12N4O4+H requires m/z 313.0932

The synthetic route of 150726-89-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Banks, Bernard Joseph; Chubb, Anthony Logan; Critcher, Douglas James; Eshelby, James John; Schulz, Darren John; US2002/61889; (2002); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 150726-89-9 as follows. Application In Synthesis of Dimethyl 2-(2-methoxyphenoxy)malonate

a) A solution of 10 g of dimethyl-(o-methoxyphenoxy)malonate (Example 1 b) in 80 ml dry methanol was cooled to 0 C. 6.71 g of sodium methylate was added portionenwise. To the suspension was added 2.84 g of acetamidine hydrochloride and the mixture was stirred overnight at room temperature. The solvent was removed under reduced pressure and the residue was suspended in 100 ml of diethyl ether. The solid was filtered off, washed with another portion of 100 ml of diethyl ether and dissolved in 50 ml of water. The pH was adjusted to 4 by adding 25 ml of glacial acetic acid. The white precipitate that formed was filtered off, washed with water and dried to yield 5.17 g of 5-(o-methoxyphenoxy)-4,6-dihydroxy-2-methyl-pyrimidine (or a tautomer) as a white powder.

According to the analysis of related databases, 150726-89-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bolli, Martin; Boss, Christoph; Clozel, Martine; Fischli, Walter; US2003/87920; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 150726-89-9, name is Dimethyl 2-(2-methoxyphenoxy)malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 150726-89-9

d) Na (2.3 g) was dissolved in methanol (40 ml) and 2-(3-methoxy-phenyl)-acetamidine hydrochloride (10 g) and (2-methoxyphenoxy)-malonic acid dimethyl ester (12.67 g) were added in succession at room temperature. The mixture was stirred for 5 hours at room temperature, concentrated in a rotary evaporator and the crude product was added to water. The aqueous phase was washed with ethyl acetate, adjusted to pH 1 and the precipitated crystals were sucked off and dried under a high vacuum. There was thus obtained 2-(3-methoxy-benzyl)-5-(2-methoxy-phenoxy)-pyrimidine-4,6-diol as beige crystals. MS: 354 (M)

The synthetic route of 150726-89-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US5837708; (1998); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics